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Protein
Submitted name:

Acetolactate synthase, catabolic

Gene

alsS

Organism
Bacillus megaterium (strain ATCC 12872 / QMB1551)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. acetolactate synthase activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. butanediol metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

TransferaseImported

Keywords - Ligandi

Thiamine pyrophosphateUniRule annotation

Enzyme and pathway databases

BioCyciBMEG545693:GHSY-789-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Acetolactate synthase, catabolicImported (EC:2.2.1.6Imported)
Gene namesi
Name:alsSImported
Ordered Locus Names:BMQ_0789Imported
OrganismiBacillus megaterium (strain ATCC 12872 / QMB1551)Imported
Taxonomic identifieri545693 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000935 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the TPP enzyme family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000258447.
KOiK01652.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR012782. Acetolactate_synth_catblc.
IPR029035. DHS-like_NAD/FAD-binding_dom.
IPR029061. THDP-binding.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR000399. TPP-bd_CS.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
PfamiPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
SSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR02418. acolac_catab. 1 hit.
PROSITEiPS00187. TPP_ENZYMES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5E116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSNADTTET KKGADLLVES LASQNVPYIF GIPGAKIDGV FDVLKEKGPE
60 70 80 90 100
VIVCRHEQNA AFMAAAMGRL TGTPGVCLVT SGPGAANLAT GLVTATSEGD
110 120 130 140 150
PVVALAGAVP RADRLKKTHQ SMDNEGLFKS IAKFSVEVED AANVPEVITD
160 170 180 190 200
AFREAVSSPS GASFVSLPQD VMDNETSAST LSVLKAPTIG AANLDAVAQA
210 220 230 240 250
IHTIRTAKLP VLLLGMRASK SKAVESIRQL IAEHDLPVVE TFQGAGAVSR
260 270 280 290 300
ELETHFFGRV GLFRNQPGDV LLKHADVVLT IGYDPVEYPP SLWNSESQRS
310 320 330 340 350
IIHLDDLQAQ ADHHYQPEIE LVGDIPSTID ILADKLPHLI RSKESASFLK
360 370 380 390 400
TLKSKLEQPD DQYEFSNDTH LHPLQLIEAL QNFVEDDTTI TCDVGSHYIW
410 420 430 440 450
MARYFRSYEP QHLLFSNGMQ TLGVALPWAI SAALVRPHKK VLSLSGDGGF
460 470 480 490 500
LFSAMELETA VRLNLPIVHI IWNDQTYDMV GFQQQIKYGR KSAVEFGSVD
510 520 530 540 550
FVTLAESFGA KGFRVNSPEE FSDTLASAFR EQGPVIIDVP VDYKDNEKLN

TQLLPDQIN
Length:559
Mass (Da):60,864
Last modified:June 15, 2010 - v1
Checksum:i0CC0779D986A9BB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001983 Genomic DNA. Translation: ADE67822.1.
RefSeqiWP_013055497.1. NC_014019.1.
YP_003561256.1. NC_014019.1.

Genome annotation databases

EnsemblBacteriaiADE67822; ADE67822; BMQ_0789.
KEGGibmq:BMQ_0789.
PATRICi35478219. VBIBacMeg35839_0784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001983 Genomic DNA. Translation: ADE67822.1.
RefSeqiWP_013055497.1. NC_014019.1.
YP_003561256.1. NC_014019.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADE67822; ADE67822; BMQ_0789.
KEGGibmq:BMQ_0789.
PATRICi35478219. VBIBacMeg35839_0784.

Phylogenomic databases

HOGENOMiHOG000258447.
KOiK01652.

Enzyme and pathway databases

BioCyciBMEG545693:GHSY-789-MONOMER.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR012782. Acetolactate_synth_catblc.
IPR029035. DHS-like_NAD/FAD-binding_dom.
IPR029061. THDP-binding.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR000399. TPP-bd_CS.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
PfamiPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
SSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR02418. acolac_catab. 1 hit.
PROSITEiPS00187. TPP_ENZYMES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequences of the industrial vitamin B12-producers B. megaterium QM B1551 and DSM319 reveal new insights into the Bacillus genome evolution and pan-genome structure."
    Eppinger M., Bunk B., Johns M.A., Edirisinghe J.N., Kutumbaka K.K., Riley D.R., Creasy H.H., Koenig S.S.K., Galens K., Orvis J., Creasy T., Biedendieck R., Braun C., Grayburn S., Jahn D., Ravel J., Vary P.S.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12872 / QMB1551Imported.

Entry informationi

Entry nameiD5E116_BACMQ
AccessioniPrimary (citable) accession number: D5E116
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: April 1, 2015
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.