D5E010 (D5E010_BACMQ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 2 PIRNR PIRNR000447
EC=2.3.1.179 PIRNR PIRNR000447

Gene names

Name:	fabF EMBL ADE67730.1
Ordered Locus Names:	BMQ_0696 EMBL ADE67730.1

Organism

Bacillus megaterium (strain ATCC 12872 / QMB1551) [Complete proteome] [HAMAP] EMBL ADE67730.1

Taxonomic identifier

545693 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus megaterium

Protein attributes

Sequence length	413 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP By similarity. PIRNR PIRNR000447
Catalytic activity	(Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein]. PIRNR PIRNR000447
Pathway	Lipid metabolism; fatty acid biosynthesis. PIRNR PIRNR000447
Sequence similarities	Belongs to the beta-ketoacyl-ACP synthases family. PIRNR PIRNR000447 RuleBase RU003694

Ontologies

Keywords
Biological process	Fatty acid biosynthesis PIRNR PIRNR000447 Fatty acid metabolism Lipid biosynthesis Lipid metabolism
Molecular function	Acyltransferase PIRNR PIRNR000447 EMBL ADE67730.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	beta-ketoacyl-acyl-carrier-protein synthase II activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D5E010 [UniParc]. Last modified June 15, 2010. Version 1. Checksum: 1C58730E997371E5	FASTA	413	43,544
	10 20 30 40 50 60 MNKKRVVVTG LGGLTPIGND VETAWKNAVA GVSGVGPLTR LDADEFPAKV AAEVKDFNVE 70 80 90 100 110 120 DFIDRKEARK MDRFTQYAMV AALAAVKDAD LTITEEIAPN VGVWIGSGIG GMETFENQYS 130 140 150 160 170 180 TLLEKGARRV SPFFIPMMIP DMATGQVSIA LGAKGVNSCT VTACATGTNS IGDAFKVIQR 190 200 210 220 230 240 GDADVMVTGG TEAPITRLSI AGFCANKALS TNPDPATASR PFDKDRDGFV MGEGAGVIVL 250 260 270 280 290 300 EELEHALARG ARIYAEIVGY GSTGDAHHIT APAPGGEGGV RAMRHAIEDA GLQPSDIDYI 310 320 330 340 350 360 NAHGTSTGYN DKFETMAIKE VFGDHAQKVA ISSTKSMTGH LLGAAGGVEA IFSVKAIQDG 370 380 390 400 410 ILPPTINYQT PDEECDLDYI PNKARKQEVK AVLSNSLGFG GHNATIIFKK YEA

References

[1]

"Genome sequences of the industrial vitamin B12-producers B. megaterium QM B1551 and DSM319 reveal new insights into the Bacillus genome evolution and pan-genome structure." Eppinger M., Bunk B., Johns M.A., Edirisinghe J.N., Kutumbaka K.K., Riley D.R., Creasy H.H., Koenig S.S.K., Galens K., Orvis J., Creasy T., Biedendieck R., Braun C., Grayburn S., Jahn D., Ravel J., Vary P.S. Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12872 / QMB1551.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001983 Genomic DNA. Translation: ADE67730.1.
RefSeq	YP_003561164.1. NC_014019.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADE67730; ADE67730; BMQ_0696.
GeneID	8985134.
KEGG	bmq:BMQ_0696.
PATRIC	35478025. VBIBacMeg35839_0688.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000060166.
KO	K09458.
Enzyme and pathway databases
BioCyc	BMEG545693:GHSY-696-MONOMER.
UniPathway	UPA00094.
Family and domain databases
Gene3D	3.40.47.10. 2 hits.
InterPro	IPR017568. 3-oxoacyl-ACP_synth-2. IPR018201. Ketoacyl_synth_AS. IPR014031. Ketoacyl_synth_C. IPR014030. Ketoacyl_synth_N. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Pfam	PF00109. ketoacyl-synt. 1 hit. PF02801. Ketoacyl-synt_C. 1 hit. [Graphical view]
PIRSF	PIRSF000447. KAS_II. 1 hit.
SUPFAM	SSF53901. Thiolase-like. 2 hits.
TIGRFAMs	TIGR03150. fabF. 1 hit.
PROSITE	PS00606. B_KETOACYL_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

D5E010_BACMQ

Accession

Primary (citable) accession number: D5E010

Entry history

Integrated into UniProtKB/TrEMBL:	June 15, 2010
Last sequence update:	June 15, 2010
Last modified:	May 29, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)