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D5DWI3

- D5DWI3_BACMQ

UniProt

D5DWI3 - D5DWI3_BACMQ

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Protein
Thymidine kinase
Gene
tdk, BMQ_5170
Organism
Bacillus megaterium (strain ATCC 12872 / QMB1551)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Proton acceptor By similarityUniRule annotation
Metal bindingi145 – 1451Zinc By similarityUniRule annotation
Metal bindingi148 – 1481Zinc By similarityUniRule annotation
Metal bindingi183 – 1831Zinc By similarityUniRule annotation
Metal bindingi186 – 1861Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATP By similarityUniRule annotation
Nucleotide bindingi88 – 914ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciBMEG545693:GHSY-5170-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:BMQ_5170Imported
OrganismiBacillus megaterium (strain ATCC 12872 / QMB1551)Imported
Taxonomic identifieri545693 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000000935: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliD5DWI3.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5DWI3-1 [UniParc]FASTAAdd to Basket

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MYVMKQSGWI EVICGSMFSG KSEELIRRVR RTQFAKQKAQ VFKPAIDNRY    50
SEEAVVSHNG TSVMAYSISA SRDILKRVNE ETDVVAIDEV QFFDTDILQI 100
VQSLADQGFR VIVAGLDQDF KGEPFGQMPQ LMAIAESVTK LQAVCASCGS 150
PASRTQRLIN GEPASYDDPI ILVGASESYE PRCRHCHVVQ KSKGQAVSVD 200
SSEMVEK 207
Length:207
Mass (Da):22,902
Last modified:June 15, 2010 - v1
Checksum:i32E99B8354C4AE6C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001983 Genomic DNA. Translation: ADE72148.1.
RefSeqiYP_003565582.1. NC_014019.1.

Genome annotation databases

EnsemblBacteriaiADE72148; ADE72148; BMQ_5170.
GeneIDi8989608.
KEGGibmq:BMQ_5170.
PATRICi35487132. VBIBacMeg35839_5196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001983 Genomic DNA. Translation: ADE72148.1 .
RefSeqi YP_003565582.1. NC_014019.1.

3D structure databases

ProteinModelPortali D5DWI3.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADE72148 ; ADE72148 ; BMQ_5170 .
GeneIDi 8989608.
KEGGi bmq:BMQ_5170.
PATRICi 35487132. VBIBacMeg35839_5196.

Phylogenomic databases

HOGENOMi HOG000076390.
KOi K00857.

Enzyme and pathway databases

BioCyci BMEG545693:GHSY-5170-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequences of the industrial vitamin B12-producers B. megaterium QM B1551 and DSM319 reveal new insights into the Bacillus genome evolution and pan-genome structure."
    Eppinger M., Bunk B., Johns M.A., Edirisinghe J.N., Kutumbaka K.K., Riley D.R., Creasy H.H., Koenig S.S.K., Galens K., Orvis J., Creasy T., Biedendieck R., Braun C., Grayburn S., Jahn D., Ravel J., Vary P.S.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12872 / QMB1551.

Entry informationi

Entry nameiD5DWI3_BACMQ
AccessioniPrimary (citable) accession number: D5DWI3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: June 11, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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