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Protein

Superoxide dismutase [Cu-Zn]

Gene

sodC

Organism
Bacillus megaterium (strain DSM 319)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciBMEG592022:GIVX-2091-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:sodCImported
Ordered Locus Names:BMD_2091Imported
OrganismiBacillus megaterium (strain DSM 319)Imported
Taxonomic identifieri592022 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000002365 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 196167Superoxide dismutase [Cu-Zn]Sequence analysisPRO_5003070307Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 194137Sod_CuInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

HOGENOMiHOG000263448.
KOiK04565.
OMAiDHSAGYH.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR024134. SOD_Cu/Zn_/chaperone.
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERiPTHR10003. PTHR10003. 1 hit.
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5DFE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKLIMNGCV VFVLLLLGAC SMVKEQNTAH ENHLKTEEAK ETSEVSVEPV
60 70 80 90 100
KVDLTNTSGK KVGEATLSEA KNGVHIKLTA QGLSPGRHGF HIHEIGKCEV
110 120 130 140 150
PDFKTAGAHF NPFKREHGLK NTKGPHAGDL PNLEVAPNGK VDTEIFASLV
160 170 180 190
TLQEGKPNSL LDMDGSALVI HDKVDDYTTD PSGNSGDRIV CGVITK
Length:196
Mass (Da):21,030
Last modified:June 15, 2010 - v1
Checksum:iB69B70DD1075E7E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001982 Genomic DNA. Translation: ADF38944.1.
RefSeqiWP_013082962.1. NC_014103.1.

Genome annotation databases

EnsemblBacteriaiADF38944; ADF38944; BMD_2091.
GeneIDi9117482.
KEGGibmd:BMD_2091.
PATRICi37254223. VBIBacMeg104484_2037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001982 Genomic DNA. Translation: ADF38944.1.
RefSeqiWP_013082962.1. NC_014103.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADF38944; ADF38944; BMD_2091.
GeneIDi9117482.
KEGGibmd:BMD_2091.
PATRICi37254223. VBIBacMeg104484_2037.

Phylogenomic databases

HOGENOMiHOG000263448.
KOiK04565.
OMAiDHSAGYH.

Enzyme and pathway databases

BioCyciBMEG592022:GIVX-2091-MONOMER.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR024134. SOD_Cu/Zn_/chaperone.
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERiPTHR10003. PTHR10003. 1 hit.
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequences of the industrial vitamin B12-producers B. megaterium QM B1551 and DSM319 reveal new insights into the Bacillus genome evolution and pan-genome structure."
    Eppinger M., Bunk B., Johns M.A., Edirisinghe J.N., Kutumbaka K.K., Riley D.R., Creasy H.H., Koenig S.S.K., Galens K., Orvis J., Creasy T., Biedendieck R., Braun C., Grayburn S., Jahn D., Ravel J., Vary P.S.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 319Imported.

Entry informationi

Entry nameiD5DFE4_BACMD
AccessioniPrimary (citable) accession number: D5DFE4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: January 20, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.