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D5DAJ0

- D5DAJ0_BACMD

UniProt

D5DAJ0 - D5DAJ0_BACMD

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Bacillus megaterium (strain DSM 319)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei195 – 1951ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase

    Keywords - Biological processi

    Protein biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBMEG592022:GIVX-705-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
    Alternative name(s):
    Tryptophanyl-tRNA synthetaseUniRule annotation
    Gene namesi
    Name:trpSUniRule annotationImported
    Ordered Locus Names:BMD_0705Imported
    OrganismiBacillus megaterium (strain DSM 319)Imported
    Taxonomic identifieri592022 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000002365: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD5DAJ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi10 – 189"HIGH" regionUniRule annotation
    Motifi192 – 1965"KMSKS" regionUniRule annotation

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000059940.
    KOiK01867.
    OMAiDYDCFFC.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_B. Trp_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D5DAJ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTIFSGIQP SGTITLGNYI GAMKQFVELQ HDYNCHFCIV DQHAITAPQD    50
    RLALRKNIRS LAALYVAVGI DPAKSTLFIQ SEVPAHTEAG WMLQCVAYIG 100
    ELERMTQFKD KSAGKEAVSA GLLTYPPLMA ADILLYNTDL VPVGEDQKQH 150
    LELTRDLAER FNKKYNDIFT IPEVRIPKVG ARVMSLQDPT KKMSKSDPNQ 200
    KAFITLLDDA KTIEKKIKSA VTDSEGIVRY DKENKPGISN LLSIYSILAN 250
    KSIEDIEAMY EGKGYGDFKA DTAKVVAEAL APIQERYYEL VDSSELDDIL 300
    DQGADKANAT ANKMLRKMRN AMGIGRKR 328
    Length:328
    Mass (Da):36,501
    Last modified:June 15, 2010 - v1
    Checksum:iFD78423C2D9A2F69
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001982 Genomic DNA. Translation: ADF37569.1.
    RefSeqiWP_013081755.1. NC_014103.1.
    YP_003595919.1. NC_014103.1.

    Genome annotation databases

    EnsemblBacteriaiADF37569; ADF37569; BMD_0705.
    GeneIDi9116096.
    KEGGibmd:BMD_0705.
    PATRICi37251379. VBIBacMeg104484_0617.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001982 Genomic DNA. Translation: ADF37569.1 .
    RefSeqi WP_013081755.1. NC_014103.1.
    YP_003595919.1. NC_014103.1.

    3D structure databases

    ProteinModelPortali D5DAJ0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADF37569 ; ADF37569 ; BMD_0705 .
    GeneIDi 9116096.
    KEGGi bmd:BMD_0705.
    PATRICi 37251379. VBIBacMeg104484_0617.

    Phylogenomic databases

    HOGENOMi HOG000059940.
    KOi K01867.
    OMAi DYDCFFC.

    Enzyme and pathway databases

    BioCyci BMEG592022:GIVX-705-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_B. Trp_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequences of the industrial vitamin B12-producers B. megaterium QM B1551 and DSM319 reveal new insights into the Bacillus genome evolution and pan-genome structure."
      Eppinger M., Bunk B., Johns M.A., Edirisinghe J.N., Kutumbaka K.K., Riley D.R., Creasy H.H., Koenig S.S.K., Galens K., Orvis J., Creasy T., Biedendieck R., Braun C., Grayburn S., Jahn D., Ravel J., Vary P.S.
      Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 319Imported.

    Entry informationi

    Entry nameiD5DAJ0_BACMD
    AccessioniPrimary (citable) accession number: D5DAJ0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3