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D5D5I9

- D5D5I9_ECOKI

UniProt

D5D5I9 - D5D5I9_ECOKI

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Protein

Beta-lactamase

Gene

ECOK1_2171

Organism
Escherichia coli O18:K1:H7 (strain IHE3034 / ExPEC)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotation

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Antibiotic resistanceUniRule annotation

Enzyme and pathway databases

BioCyciECOL714962:GI9T-2171-MONOMER.

Protein family/group databases

MEROPSiS12.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamaseUniRule annotation (EC:3.5.2.6UniRule annotation)
Gene namesi
Ordered Locus Names:ECOK1_2171Imported
OrganismiEscherichia coli O18:K1:H7 (strain IHE3034 / ExPEC)Imported
Taxonomic identifieri714962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000002364: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. outer membrane-bounded periplasmic space Source: InterPro
Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3O3VX-ray2.40A/B/C38-372[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiD5D5I9.

Family & Domainsi

Sequence similaritiesi

Belongs to the class-C beta-lactamase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000009875.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5D5I9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEHVSIKTLY HLLCCMLLFI SAMCALAQEH EPIGAQDERL STLIHQRMQE
60 70 80 90 100
AKVPALSVSV TIKGVRQRFV YGVADVASQK ANTLDTVYEL GSMSKAFTGL
110 120 130 140 150
VVQILIQEGR LRQGDDIITY LPEMRLNYQG KPASLTVADF LYHTSGLPFS
160 170 180 190 200
TLARLENPMP GSAVAQQLRN ENLLFAPGAK FSYASANYDV LGAVIENVTG
210 220 230 240 250
KTFTEVIAER LTQPLGMSAT VAVKGDEIIV NKASGYKLGF GKPVLFHAPL
260 270 280 290 300
ARNHVPAAYI HSTLPDMEIW IDAWLHRKAL PATLREAMSN SWRGNSDVPL
310 320 330 340 350
AADNRILYAS GWFIDQNQGP YISHGGQNPN FSSCIALRPD QQIGIVALAN
360 370 380 390 400
MNSNLILQLC ADIDNYLRIG KYADGAGDAI TATDTLFVYL TLLLCFWGAV
410 420 430 440 450
VVVRGAFRVY RATAHGPGKQ QRLRLRVRDY IIALAVPGLV AAMLYVAPGI
460 470 480 490 500
LSPGLDWRFI LVWGPSSVLA IPFGIILLAF VLTLNHQIKR ILLHNKEWDD

E
Length:501
Mass (Da):55,127
Last modified:June 15, 2010 - v1
Checksum:iC3CF745585E53F98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001969 Genomic DNA. Translation: ADE91541.1.
RefSeqiYP_006101336.1. NC_017628.1.

Genome annotation databases

EnsemblBacteriaiADE91541; ADE91541; ECOK1_2171.
GeneIDi12690739.
KEGGieih:ECOK1_2171.
PATRICi36705781. VBIEscCol148715_2208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001969 Genomic DNA. Translation: ADE91541.1 .
RefSeqi YP_006101336.1. NC_017628.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3O3V X-ray 2.40 A/B/C 38-372 [» ]
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S12.010.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADE91541 ; ADE91541 ; ECOK1_2171 .
GeneIDi 12690739.
KEGGi eih:ECOK1_2171.
PATRICi 36705781. VBIEscCol148715_2208.

Phylogenomic databases

HOGENOMi HOG000009875.

Enzyme and pathway databases

BioCyci ECOL714962:GI9T-2171-MONOMER.

Miscellaneous databases

EvolutionaryTracei D5D5I9.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IHE3034 / ExPECImported.
  2. "Identification of protective and broadly conserved vaccine antigens from the genome of Extraintestinal Pathogenic Escherichia coli (ExPEC)."
    Moriel D.G., Bertoldi I., Spagnuolo A., Marchi S., Rosini R., Nesta B., Pastorello I., Mariani Corea V.A., Torricelli G., Cartocci E., Savino S., Scarselli M., Dobrindt U., Hacker J., Tettelin H., Wieler L.H., Ewers C., Picard D.
    , Dougan G., Fontana M.R., Rappuoli R., Pizza M., Serino L.
    Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2010)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: IHE3034.
  3. "ClbP x-ray structure, the prototype of a peptidase family associated to NRP production."
    Dubois D., Baron O., Cougnoux A., Delmas J., Pradel N., Nougayrede J.P., Robin F., Oswald E., Bonnet R.
    Submitted (JUL-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 38-372, ACTIVE SITE.

Entry informationi

Entry nameiD5D5I9_ECOKI
AccessioniPrimary (citable) accession number: D5D5I9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: November 26, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteomeImported

External Data

Dasty 3