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D5D5I9

- D5D5I9_ECOKI

UniProt

D5D5I9 - D5D5I9_ECOKI

Protein

Beta-lactamase

Gene

ECOK1_2171

Organism
Escherichia coli O18:K1:H7 (strain IHE3034 / ExPEC)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotation

    GO - Molecular functioni

    1. beta-lactamase activity Source: InterPro

    GO - Biological processi

    1. antibiotic catabolic process Source: InterPro

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Biological processi

    Antibiotic resistanceUniRule annotation

    Enzyme and pathway databases

    BioCyciECOL714962:GI9T-2171-MONOMER.

    Protein family/group databases

    MEROPSiS12.010.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamaseUniRule annotation (EC:3.5.2.6UniRule annotation)
    Gene namesi
    Ordered Locus Names:ECOK1_2171Imported
    OrganismiEscherichia coli O18:K1:H7 (strain IHE3034 / ExPEC)Imported
    Taxonomic identifieri714962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000002364: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. outer membrane-bounded periplasmic space Source: InterPro

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3O3VX-ray2.40A/B/C38-372[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiD5D5I9.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-C beta-lactamase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000009875.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR001586. Beta-lactam_class-C_AS.
    [Graphical view]
    PfamiPF00144. Beta-lactamase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00336. BETA_LACTAMASE_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D5D5I9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEHVSIKTLY HLLCCMLLFI SAMCALAQEH EPIGAQDERL STLIHQRMQE    50
    AKVPALSVSV TIKGVRQRFV YGVADVASQK ANTLDTVYEL GSMSKAFTGL 100
    VVQILIQEGR LRQGDDIITY LPEMRLNYQG KPASLTVADF LYHTSGLPFS 150
    TLARLENPMP GSAVAQQLRN ENLLFAPGAK FSYASANYDV LGAVIENVTG 200
    KTFTEVIAER LTQPLGMSAT VAVKGDEIIV NKASGYKLGF GKPVLFHAPL 250
    ARNHVPAAYI HSTLPDMEIW IDAWLHRKAL PATLREAMSN SWRGNSDVPL 300
    AADNRILYAS GWFIDQNQGP YISHGGQNPN FSSCIALRPD QQIGIVALAN 350
    MNSNLILQLC ADIDNYLRIG KYADGAGDAI TATDTLFVYL TLLLCFWGAV 400
    VVVRGAFRVY RATAHGPGKQ QRLRLRVRDY IIALAVPGLV AAMLYVAPGI 450
    LSPGLDWRFI LVWGPSSVLA IPFGIILLAF VLTLNHQIKR ILLHNKEWDD 500
    E 501
    Length:501
    Mass (Da):55,127
    Last modified:June 15, 2010 - v1
    Checksum:iC3CF745585E53F98
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001969 Genomic DNA. Translation: ADE91541.1.
    RefSeqiYP_006101336.1. NC_017628.1.

    Genome annotation databases

    EnsemblBacteriaiADE91541; ADE91541; ECOK1_2171.
    GeneIDi12690739.
    KEGGieih:ECOK1_2171.
    PATRICi36705781. VBIEscCol148715_2208.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001969 Genomic DNA. Translation: ADE91541.1 .
    RefSeqi YP_006101336.1. NC_017628.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3O3V X-ray 2.40 A/B/C 38-372 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S12.010.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADE91541 ; ADE91541 ; ECOK1_2171 .
    GeneIDi 12690739.
    KEGGi eih:ECOK1_2171.
    PATRICi 36705781. VBIEscCol148715_2208.

    Phylogenomic databases

    HOGENOMi HOG000009875.

    Enzyme and pathway databases

    BioCyci ECOL714962:GI9T-2171-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei D5D5I9.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR001586. Beta-lactam_class-C_AS.
    [Graphical view ]
    Pfami PF00144. Beta-lactamase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00336. BETA_LACTAMASE_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IHE3034 / ExPECImported.
    2. "Identification of protective and broadly conserved vaccine antigens from the genome of Extraintestinal Pathogenic Escherichia coli (ExPEC)."
      Moriel D.G., Bertoldi I., Spagnuolo A., Marchi S., Rosini R., Nesta B., Pastorello I., Mariani Corea V.A., Torricelli G., Cartocci E., Savino S., Scarselli M., Dobrindt U., Hacker J., Tettelin H., Wieler L.H., Ewers C., Picard D.
      , Dougan G., Fontana M.R., Rappuoli R., Pizza M., Serino L.
      Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2010)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: IHE3034.
    3. "ClbP x-ray structure, the prototype of a peptidase family associated to NRP production."
      Dubois D., Baron O., Cougnoux A., Delmas J., Pradel N., Nougayrede J.P., Robin F., Oswald E., Bonnet R.
      Submitted (JUL-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 38-372.

    Entry informationi

    Entry nameiD5D5I9_ECOKI
    AccessioniPrimary (citable) accession number: D5D5I9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3