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D5D5I9

- D5D5I9_ECOKI

UniProt

D5D5I9 - D5D5I9_ECOKI

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Protein
Beta-lactamase
Gene
ECOK1_2171
Organism
Escherichia coli O18:K1:H7 (strain IHE3034 / ExPEC)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotation

GO - Molecular functioni

  1. beta-lactamase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Antibiotic resistanceUniRule annotation

Enzyme and pathway databases

BioCyciECOL714962:GI9T-2171-MONOMER.

Protein family/group databases

MEROPSiS12.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamaseUniRule annotation (EC:3.5.2.6UniRule annotation)
Gene namesi
Ordered Locus Names:ECOK1_2171Imported
OrganismiEscherichia coli O18:K1:H7 (strain IHE3034 / ExPEC)Imported
Taxonomic identifieri714962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000002364: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. outer membrane-bounded periplasmic space Source: InterPro
Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3O3VX-ray2.40A/B/C38-372[»]

Miscellaneous databases

EvolutionaryTraceiD5D5I9.

Family & Domainsi

Sequence similaritiesi

Belongs to the class-C beta-lactamase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000009875.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5D5I9-1 [UniParc]FASTAAdd to Basket

« Hide

MEHVSIKTLY HLLCCMLLFI SAMCALAQEH EPIGAQDERL STLIHQRMQE    50
AKVPALSVSV TIKGVRQRFV YGVADVASQK ANTLDTVYEL GSMSKAFTGL 100
VVQILIQEGR LRQGDDIITY LPEMRLNYQG KPASLTVADF LYHTSGLPFS 150
TLARLENPMP GSAVAQQLRN ENLLFAPGAK FSYASANYDV LGAVIENVTG 200
KTFTEVIAER LTQPLGMSAT VAVKGDEIIV NKASGYKLGF GKPVLFHAPL 250
ARNHVPAAYI HSTLPDMEIW IDAWLHRKAL PATLREAMSN SWRGNSDVPL 300
AADNRILYAS GWFIDQNQGP YISHGGQNPN FSSCIALRPD QQIGIVALAN 350
MNSNLILQLC ADIDNYLRIG KYADGAGDAI TATDTLFVYL TLLLCFWGAV 400
VVVRGAFRVY RATAHGPGKQ QRLRLRVRDY IIALAVPGLV AAMLYVAPGI 450
LSPGLDWRFI LVWGPSSVLA IPFGIILLAF VLTLNHQIKR ILLHNKEWDD 500
E 501
Length:501
Mass (Da):55,127
Last modified:June 15, 2010 - v1
Checksum:iC3CF745585E53F98
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001969 Genomic DNA. Translation: ADE91541.1.
RefSeqiYP_006101336.1. NC_017628.1.

Genome annotation databases

EnsemblBacteriaiADE91541; ADE91541; ECOK1_2171.
GeneIDi12690739.
KEGGieih:ECOK1_2171.
PATRICi36705781. VBIEscCol148715_2208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001969 Genomic DNA. Translation: ADE91541.1 .
RefSeqi YP_006101336.1. NC_017628.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3O3V X-ray 2.40 A/B/C 38-372 [» ]
ModBasei Search...

Protein family/group databases

MEROPSi S12.010.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADE91541 ; ADE91541 ; ECOK1_2171 .
GeneIDi 12690739.
KEGGi eih:ECOK1_2171.
PATRICi 36705781. VBIEscCol148715_2208.

Phylogenomic databases

HOGENOMi HOG000009875.

Enzyme and pathway databases

BioCyci ECOL714962:GI9T-2171-MONOMER.

Miscellaneous databases

EvolutionaryTracei D5D5I9.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IHE3034 / ExPEC.
  2. "Identification of protective and broadly conserved vaccine antigens from the genome of Extraintestinal Pathogenic Escherichia coli (ExPEC)."
    Moriel D.G., Bertoldi I., Spagnuolo A., Marchi S., Rosini R., Nesta B., Pastorello I., Mariani Corea V.A., Torricelli G., Cartocci E., Savino S., Scarselli M., Dobrindt U., Hacker J., Tettelin H., Wieler L.H., Ewers C., Picard D.
    , Dougan G., Fontana M.R., Rappuoli R., Pizza M., Serino L.
    Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2010)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: IHE3034.
  3. "ClbP x-ray structure, the prototype of a peptidase family associated to NRP production."
    Dubois D., Baron O., Cougnoux A., Delmas J., Pradel N., Nougayrede J.P., Robin F., Oswald E., Bonnet R.
    Submitted (JUL-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 38-372.

Entry informationi

Entry nameiD5D5I9_ECOKI
AccessioniPrimary (citable) accession number: D5D5I9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: September 3, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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