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D5CP20 (D5CP20_SIDLE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Slit_2716 EMBL ADE12941.1
OrganismSideroxydans lithotrophicus (strain ES-1) [Complete proteome] [HAMAP] EMBL ADE12941.1
Taxonomic identifier580332 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaGallionellalesGallionellaceaeSideroxydans

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain108 – 303196ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding134 – 18956ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2571Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2701Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2701Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2721Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D5CP20 [UniParc].

Last modified June 15, 2010. Version 1.
Checksum: 8FFF3324F199D2F8

FASTA30933,525
        10         20         30         40         50         60 
MDKSIPTSFG KVAVLFGGRS AEREVSLKSG AAVLAALLKS GVDAHAFDPA QRDLSELKKE 

        70         80         90        100        110        120 
KFDRVFIILH GRYGEDGTVQ GALELMDIPY TGSGVMASAI AMDKWRTKLV WQAAGLPIPE 

       130        140        150        160        170        180 
YEALTAPSDW NAVADHLDLP LFVKPSSEGS SVGVTKVKTV DELPIAYAEA AKYDKVVIAE 

       190        200        210        220        230        240 
SFMSGGEYTA TILNGRALPV IKIEPANEFY DYEAKYLRDD TRYLCPCGLS VEQEAEMQHL 

       250        260        270        280        290        300 
ALLAFQLIGC QGWGRVDFLR GDDGKFYLLE INTAPGMTDH SLVPMAARQA GISFEQLVVQ 


ILEGAGIGK 

« Hide

References

[1]"Complete sequence of Sideroxydans lithotrophicus ES-1."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Emerson D., Woyke T.
Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ES-1 EMBL ADE12941.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001965 Genomic DNA. Translation: ADE12941.1.
RefSeqYP_003525328.1. NC_013959.1.

3D structure databases

ProteinModelPortalD5CP20.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADE12941; ADE12941; Slit_2716.
GeneID8893422.
KEGGslt:Slit_2716.
PATRIC35403550. VBISidLit69165_2685.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011592.
KOK01921.

Enzyme and pathway databases

BioCycSLIT580332:GH9F-2768-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD5CP20_SIDLE
AccessionPrimary (citable) accession number: D5CP20
Entry history
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: June 11, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)