folE2

Functionⁱ

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotationSAAS annotation

Catalytic activityⁱ

GTP + H₂O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotationSAAS annotation

Pathwayⁱ: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:

GTP cyclohydrolase FolE2 (folE2)

This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	151	May be catalytically importantUniRule annotation		1

GO - Molecular functionⁱ

GTP cyclohydrolase I activity Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	HydrolaseUniRule annotationSAAS annotation

Molecular function

HydrolaseUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCycⁱ	SLIT580332:G1GHN-707-MONOMER.
UniPathwayⁱ	UPA00848; UER00151.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesⁱ	Name:folE2UniRule annotation Ordered Locus Names:Slit_0707Imported
Organismⁱ	Sideroxydans lithotrophicus (strain ES-1)Imported
Taxonomic identifierⁱ	580332 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Nitrosomonadales › Gallionellaceae › Sideroxydans › Sideroxydans lithotrophicus
Proteomesⁱ	UP000001625 Componentⁱ: Chromosome

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	580332.Slit_0707.

STRINGⁱ

580332.Slit_0707.

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the GTP cyclohydrolase IV family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105DZA. Bacteria. COG1469. LUCA.
HOGENOMⁱ	HOG000280679.
KEGG Orthology (KO) More...KOⁱ	K09007.
OMAⁱ	HNQRGRG.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0MIO.

Family and domain databases

HAMAPⁱ	MF_01527_B. GTP_cyclohydrol_B. 1 hit.
InterProⁱ	View protein in InterPro IPR022838. GTP_cyclohydrolase_FolE2. IPR003801. GTP_cyclohydrolase_FolE2/MptA.
PANTHERⁱ	PTHR36445. PTHR36445. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02649. GCHY-1. 1 hit.
TIGRFAMsⁱ	TIGR00294. TIGR00294. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

D5CNN3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNSIETIADV QNSADTRQLA INKVGIKSIR HPVVVKDKSE GVQHTIATFN 
        60         70         80         90        100
MYVHLPHNFK GTHMSRFVQI LNQHGREISV ESFEGILREM TEKLEAKSGY 
       110        120        130        140        150
IEMSFPYFVN KTAPISEVQS LLDYDVTFIG EIVDGNYRFN MKVQIPVTSL 
       160        170        180        190        200
CPCSKEISER GAHNQRSHVT ITVRTRRSVW IEEVVRFAEE QASSELYGLL 
       210        220        230        240        250
KRPDEKFVTE RAYDNPKFVE DMVRDVAAVL NADERIEAYI VESENFESIH 
       260 
NHSAYALIER DKTKD

Length:265

Mass (Da):30,399

Last modified:June 15, 2010 - v1

Checksum:ⁱ4772A438A3E6A5D3

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001965 Genomic DNA. Translation: ADE10946.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_013028845.1. NC_013959.1.

Genome annotation databases

EnsemblBacteriaⁱ	ADE10946; ADE10946; Slit_0707.
KEGGⁱ	slt:Slit_0707.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
D5CNN3	A0A1G3IKI2 A0A1G3IQV3	Sideroxydans sp. GWF2_59_14 Sideroxydans sp. RIFOXYB12_FULL_59_6	265	UniRef90_D5CNN3	Cluster: GTP cyclohydrolase FolE2	3

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
D5CNN3	A1AU47 A0A1G0M9K0 A0A2E3A2F1 B6BUT0 A0A0H4IY92 D3PA15 A0A1G3IKI2 A0A1G3IQV3 A0A2E4GPL6 A0A1F9BAZ3 +210	Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1) Geobacteraceae bacterium GWC2_55_20 Verrucomicrobiales bacterium beta proteobacterium KB13 Methylophilales bacterium MBRS-H7 Deferribacter desulfuricans (strain DSM 14783 / JCM 11476 / NBRC 101012 / SSM1) Sideroxydans sp. GWF2_59_14 Sideroxydans sp. RIFOXYB12_FULL_59_6 Verrucomicrobiaceae bacterium Deltaproteobacteria bacterium RBG_16_44_11 And more	257	UniRef50_A1AU47	Cluster: GTP cyclohydrolase FolE2	221

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001965 Genomic DNA. Translation: ADE10946.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_013028845.1. NC_013959.1.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	580332.Slit_0707.

STRINGⁱ

580332.Slit_0707.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ADE10946; ADE10946; Slit_0707.
KEGGⁱ	slt:Slit_0707.

Phylogenomic databases

eggNOGⁱ	ENOG4105DZA. Bacteria. COG1469. LUCA.
HOGENOMⁱ	HOG000280679.
KEGG Orthology (KO) More...KOⁱ	K09007.
OMAⁱ	HNQRGRG.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0MIO.

Enzyme and pathway databases

UniPathwayⁱ	UPA00848; UER00151.
BioCycⁱ	SLIT580332:G1GHN-707-MONOMER.

Family and domain databases

HAMAPⁱ	MF_01527_B. GTP_cyclohydrol_B. 1 hit.
InterProⁱ	View protein in InterPro IPR022838. GTP_cyclohydrolase_FolE2. IPR003801. GTP_cyclohydrolase_FolE2/MptA.
PANTHERⁱ	PTHR36445. PTHR36445. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02649. GCHY-1. 1 hit.
TIGRFAMsⁱ	TIGR00294. TIGR00294. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D5CNN3_SIDLE
Accessionⁱ	D5CNN3Primary (citable) accession number: D5CNN3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 15, 2010
	Last sequence update:	June 15, 2010
	Last modified:	March 28, 2018
	This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - D5CNN3 (D5CNN3_SIDLE)

Your basket is currently empty. ⁱ

GTP cyclohydrolase FolE2

Select a section on the left to see content.

Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: 7,8-dihydroneopterin triphosphate biosynthesis

Sites

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Interactionⁱ

Protein-protein interaction databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D5CNN3 (D5CNN3_SIDLE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

GTP cyclohydrolase FolE2

folE2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Your basket is currently empty. ⁱ

Functionⁱ

Pathwayⁱ: 7,8-dihydroneopterin triphosphate biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ