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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC 13535 / NCDC 279-56)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381UniRule annotation
Active sitei546 – 5461UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciECLO716541:GH13-5103-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:ECL_05032Imported
OrganismiEnterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC 13535 / NCDC 279-56)Imported
Taxonomic identifieri716541 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacterEnterobacter cloacae complex
ProteomesiUP000002363: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000238648.
KOiK01595.
OMAiCGMGVIA.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5CGQ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNEQYSALRS NVSMLGKVLG DTIKDALGEN ILDRVETIRK LSKSSRAGNE
60 70 80 90 100
ASRQELLTTL QNLSNDELLP VARAFSQFLN LANTAEQYHS ISPNGEAASN
110 120 130 140 150
PEVIARTLRK LKDQPNLNEA TIKKAVESLS LELVLTAHPT EITRRTLIHK
160 170 180 190 200
MVEVNNCLKQ LDNKDIADYE RNQLMRRLRQ LIAQSWHTDE IRKHRPSPVD
210 220 230 240 250
EAKWGFAVVE NSLWEGVPNY LRELNEQLEA NLGYRLPVDF VPVRFTSWMG
260 270 280 290 300
GDRDGNPNVT AEITRHVLLL SRWKATDLFL KDIQVLISEL SMVEATPELR
310 320 330 340 350
ALAGEEGASE PYRFLMKKLR SQLMATQAWL EARLKGQRLP KPEGLLSQNE
360 370 380 390 400
QLWEPLYACY KSLQACGMGI IANGELLDTL RRVKCFGVPL VRIDVRQEST
410 420 430 440 450
RHTEALGELT RYLGIGDYES WSEADKQAFL IRELNSKRPL LPRNWEPSNE
460 470 480 490 500
TREVLNTCKA IVDAPKGSVA AYVISMAKTP SDVLAVHLLL KEAGIDYALP
510 520 530 540 550
VAPLFETLDD LNNANDVMTQ LLNIDWYRGF IQGKQMVMIG YSDSAKDAGV
560 570 580 590 600
MAASWAQYQA QDALIKTCEK AGIELTLFHG RGGSIGRGGA PAHAALLSQP
610 620 630 640 650
PGSLKGGLRV TEQGEMIRFK YGLPEVTISS LSLYTSAILE ANLLPPPEPK
660 670 680 690 700
ESWCRIMDEL SDISCDLYRG YVRENKDFVP YFRSATPEQE LGKLPLGSRP
710 720 730 740 750
AKRRPTGGVE SLRAIPWIFA WTQNRLMLPA WLGAGAALQK VVEDGKQNEL
760 770 780 790 800
ETMCRDWPFF STRLGMLEMV FSKADLWLAE YYDQRLVKPE LWALGKELRE
810 820 830 840 850
LLEGDIKVVL DIANDSHLMA DLPWIAESIQ LRNIYTDPLN VLQAELLHRS
860 870 880
RLAEEEGKDP DPRVEQALMV TIAGVAAGMR NTG
Length:883
Mass (Da):99,136
Last modified:June 15, 2010 - v1
Checksum:i5FB29A9CA9AECBF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001918 Genomic DNA. Translation: ADF64554.1.
RefSeqiYP_003615503.1. NC_014121.1.

Genome annotation databases

EnsemblBacteriaiADF64554; ADF64554; ECL_05032.
GeneIDi9127497.
KEGGienc:ECL_05032.
PATRICi38460991. VBIEntClo148801_5165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001918 Genomic DNA. Translation: ADF64554.1.
RefSeqiYP_003615503.1. NC_014121.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADF64554; ADF64554; ECL_05032.
GeneIDi9127497.
KEGGienc:ECL_05032.
PATRICi38460991. VBIEntClo148801_5165.

Phylogenomic databases

HOGENOMiHOG000238648.
KOiK01595.
OMAiCGMGVIA.

Enzyme and pathway databases

BioCyciECLO716541:GH13-5103-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Enterobacter cloacae subsp. cloacae type strain ATCC 13047."
    Ren Y., Ren Y., Zhou Z., Guo X., Li Y., Feng L., Wang L.
    J. Bacteriol. 192:2463-2464(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13047 / DSM 30054 / NBRC 13535 / NCDC 279-56Imported.

Entry informationi

Entry nameiD5CGQ5_ENTCC
AccessioniPrimary (citable) accession number: D5CGQ5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: February 4, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.