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D5CFA4 (D5CFA4_ENTCC) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length231 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity By similarity. HAMAP-Rule MF_01146

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_01146

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01146.

Domain

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA) By similarity. HAMAP-Rule MF_01146

Sequence similarities

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification] HAMAP-Rule MF_01146

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Transmembrane9 – 2921Helical; By similarity HAMAP-Rule MF_01146
Transmembrane34 – 5421Helical; By similarity HAMAP-Rule MF_01146
Transmembrane82 – 10221Helical; By similarity HAMAP-Rule MF_01146
Transmembrane129 – 14921Helical; By similarity HAMAP-Rule MF_01146
Transmembrane160 – 18021Helical; By similarity HAMAP-Rule MF_01146
Transmembrane202 – 22221Helical; By similarity HAMAP-Rule MF_01146
Motif63 – 653NPA 1 By similarity HAMAP-Rule MF_01146
Motif186 – 1883NPA 2 By similarity HAMAP-Rule MF_01146

Sites

Site201Involved in tetramerization or stability of the tetramer By similarity HAMAP-Rule MF_01146
Site431Selectivity filter By similarity HAMAP-Rule MF_01146
Site1741Selectivity filter By similarity HAMAP-Rule MF_01146
Site1831Selectivity filter By similarity HAMAP-Rule MF_01146
Site1891Selectivity filter By similarity HAMAP-Rule MF_01146

Sequences

Sequence LengthMass (Da)Tools
D5CFA4 [UniParc].

Last modified June 15, 2010. Version 1.
Checksum: 00E7BD2E3187F818

FASTA23123,727
        10         20         30         40         50         60 
MFRKLAAECF GTFWLVFGGC GSAVLAAAFP ELGIGFVGVA LAFGLTVLTM AFAVGHISGG 

        70         80         90        100        110        120 
HFNPAVTLGL WAGGRFPAKE VIGYIVAQVV GGIIAAAVLY VIASGKAGFD AAASGFASNG 

       130        140        150        160        170        180 
FGEHSPGGYS MLSAIVIEIV LTAGFLLVIH GATDKYAPAG FAPIAIGLAL TLIHLISIPV 

       190        200        210        220        230 
TNTSVNPARS TAVAIFQGGW ALEQLWLFWV MPIVGGILGG VLYRTLLEKR D

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References

[1]"Complete genome sequence of Enterobacter cloacae subsp. cloacae type strain ATCC 13047."
Ren Y., Ren Y., Zhou Z., Guo X., Li Y., Feng L., Wang L.
J. Bacteriol. 192:2463-2464(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13047 / DSM 30054 / NBRC 13535 / NCDC 279-56.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001918 Genomic DNA. Translation: ADF62317.1.
RefSeqYP_003613266.1. NC_014121.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADF62317; ADF62317; ECL_02776.
GeneID9125260.
KEGGenc:ECL_02776.
PATRIC38456443. VBIEntClo148801_2954.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000288286.
KOK06188.

Enzyme and pathway databases

BioCycECLO716541:GH13-2801-MONOMER.

Family and domain databases

Gene3D1.20.1080.10. 1 hit.
HAMAPMF_01146. Aquaporin_Z.
InterProIPR023271. Aquaporin-like.
IPR023743. Aquaporin_Z.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERPTHR19139. PTHR19139. 1 hit.
PfamPF00230. MIP. 1 hit.
[Graphical view]
PRINTSPR00783. MINTRINSICP.
SUPFAMSSF81338. MIP. 1 hit.
TIGRFAMsTIGR00861. MIP. 1 hit.
PROSITEPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD5CFA4_ENTCC
AccessionPrimary (citable) accession number: D5CFA4
Entry history
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: May 29, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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