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Protein

Xylose isomerase

Gene

xylA

Organism
Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC 13535 / NCDC 279-56)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei122 – 1221UniRule annotation
Active sitei125 – 1251UniRule annotation
Metal bindingi253 – 2531Magnesium 1UniRule annotation
Metal bindingi289 – 2891Magnesium 1UniRule annotation
Metal bindingi289 – 2891Magnesium 2UniRule annotation
Metal bindingi292 – 2921Magnesium 2UniRule annotation
Metal bindingi317 – 3171Magnesium 1UniRule annotation
Metal bindingi328 – 3281Magnesium 2UniRule annotation
Metal bindingi330 – 3301Magnesium 2UniRule annotation
Metal bindingi360 – 3601Magnesium 1UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotation, Xylose metabolismUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciECLO716541:GH13-202-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotation
Ordered Locus Names:ECL_00201Imported
OrganismiEnterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC 13535 / NCDC 279-56)Imported
Taxonomic identifieri716541 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacterEnterobacter cloacae complex
ProteomesiUP000002363 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD5CBH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5CBH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIHYYSCIN DSPHTLIMEL NMQAYFDQLD RVRYEGPKTT NPLAFRHYNP
60 70 80 90 100
DELVLGKRME DHLRFAACYW HTFCWNGADM FGVGSFDRPW QQPGEAIELA
110 120 130 140 150
KRKADVAFEF FHKLNVPYYC FHDVDVSPEG ASLKEYLNNF AQMVDVLAAK
160 170 180 190 200
QQQSGVKLLW GTANCFTNPR YGAGAATNPD PEVFSWAATQ VVTAMNATHQ
210 220 230 240 250
LGGENYVLWG GREGYETLLN TDLRQEREQI GRFMQMVVEH KHKIGFRGTL
260 270 280 290 300
LIEPKPQEPT KHQYDYDVAT VYGFLKQFGL EKEIKVNIEA NHATLAGHSF
310 320 330 340 350
HHEIASAIAL GIFGSVDANR GDAQLGWDTD QFPNSVEENA LVMYEIIKAG
360 370 380 390 400
GFTTGGLNFD AKVRRQSTDK YDLFYGHIGA MDTMALALKV AARMIEDGEL
410 420 430 440 450
DKRVAKRYSG WNSELGQQIL KGQLSLAEIA KYAEQHQLAP QHQSGHQELL
460
ENLVNHYLFD K
Length:461
Mass (Da):52,261
Last modified:June 15, 2010 - v1
Checksum:iBFD58C9651FA53E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001918 Genomic DNA. Translation: ADF59769.1.
RefSeqiWP_013094964.1. NC_014121.1.
YP_003610718.1. NC_014121.1.

Genome annotation databases

EnsemblBacteriaiADF59769; ADF59769; ECL_00201.
GeneIDi9122712.
KEGGienc:ECL_00201.
PATRICi38451431. VBIEntClo148801_0494.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001918 Genomic DNA. Translation: ADF59769.1.
RefSeqiWP_013094964.1. NC_014121.1.
YP_003610718.1. NC_014121.1.

3D structure databases

ProteinModelPortaliD5CBH1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADF59769; ADF59769; ECL_00201.
GeneIDi9122712.
KEGGienc:ECL_00201.
PATRICi38451431. VBIEntClo148801_0494.

Phylogenomic databases

HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.

Enzyme and pathway databases

BioCyciECLO716541:GH13-202-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Enterobacter cloacae subsp. cloacae type strain ATCC 13047."
    Ren Y., Ren Y., Zhou Z., Guo X., Li Y., Feng L., Wang L.
    J. Bacteriol. 192:2463-2464(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13047 / DSM 30054 / NBRC 13535 / NCDC 279-56Imported.

Entry informationi

Entry nameiD5CBH1_ENTCC
AccessioniPrimary (citable) accession number: D5CBH1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: April 29, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.