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D5C1B7

- D5C1B7_NITHN

UniProt

D5C1B7 - D5C1B7_NITHN

Protein

Ribulose bisphosphate carboxylase large chain

Gene

cbbL

Organism
Nitrosococcus halophilus (strain Nc4)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.UniRule annotation

    Catalytic activityi

    2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
    3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei131 – 1311Substrate; in homodimeric partnerUniRule annotation
    Binding sitei181 – 1811SubstrateUniRule annotation
    Active sitei183 – 1831Proton acceptorUniRule annotation
    Binding sitei185 – 1851SubstrateUniRule annotation
    Metal bindingi209 – 2091Magnesium; via carbamate groupUniRule annotation
    Metal bindingi211 – 2111MagnesiumUniRule annotation
    Metal bindingi212 – 2121MagnesiumUniRule annotation
    Active sitei301 – 3011Proton acceptorUniRule annotation
    Binding sitei302 – 3021SubstrateUniRule annotation
    Binding sitei334 – 3341SubstrateUniRule annotation
    Sitei341 – 3411Transition state stabilizerUniRule annotation
    Binding sitei386 – 3861SubstrateUniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. monooxygenase activity Source: UniProtKB-KW
    3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. reductive pentose-phosphate cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    LyaseUniRule annotationImported, MonooxygenaseUniRule annotation, Oxidoreductase

    Keywords - Biological processi

    Calvin cycleUniRule annotation, Carbon dioxide fixationUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciNHAL472759:GHH2-3489-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribulose bisphosphate carboxylase large chainUniRule annotation (EC:4.1.1.39UniRule annotation)
    Short name:
    RuBisCO large subunitUniRule annotation
    Gene namesi
    Name:cbbLUniRule annotation
    Ordered Locus Names:Nhal_3442Imported
    OrganismiNitrosococcus halophilus (strain Nc4)Imported
    Taxonomic identifieri472759 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeNitrosococcus
    ProteomesiUP000001844: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei209 – 2091N6-carboxylysineUniRule annotation

    Interactioni

    Subunit structurei

    Heterohexadecamer of 8 large chains and 8 small chains.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD5C1B7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RuBisCO large chain family. Type I subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000230831.
    KOiK01601.

    Family and domain databases

    Gene3Di3.20.20.110. 1 hit.
    3.30.70.150. 1 hit.
    HAMAPiMF_01338. RuBisCO_L_type1.
    InterProiIPR020878. RuBisCo_large_chain_AS.
    IPR020888. RuBisCO_lsu.
    IPR000685. RuBisCO_lsu_C.
    IPR017443. RuBisCO_lsu_fd_N.
    IPR017444. RuBisCO_lsu_N.
    [Graphical view]
    PfamiPF00016. RuBisCO_large. 1 hit.
    PF02788. RuBisCO_large_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF51649. SSF51649. 1 hit.
    SSF54966. SSF54966. 1 hit.
    PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D5C1B7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKSETMAEG KERYKSGVIP YKKMGYWEPD YKPKETDIIA MFRITPQAGV    50
    DPAEAAAAVA GESSTATWTV VWTDRLTACE LYRAKAYRVD PVPNTGEGTK 100
    TEAQYFAYIA YDLDLFEPGS IANLTASIIG NVFGFKAVKA LRLEDMHIPV 150
    AYLKTFQGPA TGVIVERERL DKFGRPLLGA TTKPKLGLSG RNYGRVVYEA 200
    LKGGLDFVKD DENINSQPFM HWRDRFLYCM EAVNKASAAT GEVKGHYLNV 250
    TAATMEDMYE RAEFAKSLGS VIIMIDLVVG YTAIQSMAKW ARKNDMVLHL 300
    HRAGNSTYSR QKNHGMNFRV ICKWMRMAGV DHIHAGTVVG KLEGDPLMIK 350
    GFYDTLRERH TPTSLEHGLF FDQDWASLNK VMPVASGGIH AGQMHQLLHY 400
    LGEDVVLQFG GGTIGHPQGI QAGATANRVA LEAMIMARNE GRDYMKEGPQ 450
    ILEDAAKWCS PLKAALDTWK DITFNYESTD TADFVPTATT SV 492
    Length:492
    Mass (Da):54,513
    Last modified:June 15, 2010 - v1
    Checksum:i5620AFFE070F1BAB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001798 Genomic DNA. Translation: ADE16469.1.
    RefSeqiWP_013034318.1. NC_013960.1.
    YP_003528856.1. NC_013960.1.

    Genome annotation databases

    EnsemblBacteriaiADE16469; ADE16469; Nhal_3442.
    GeneIDi8918453.
    KEGGinhl:Nhal_3442.
    PATRICi35397002. VBINitHal115488_3612.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001798 Genomic DNA. Translation: ADE16469.1 .
    RefSeqi WP_013034318.1. NC_013960.1.
    YP_003528856.1. NC_013960.1.

    3D structure databases

    ProteinModelPortali D5C1B7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADE16469 ; ADE16469 ; Nhal_3442 .
    GeneIDi 8918453.
    KEGGi nhl:Nhal_3442.
    PATRICi 35397002. VBINitHal115488_3612.

    Phylogenomic databases

    HOGENOMi HOG000230831.
    KOi K01601.

    Enzyme and pathway databases

    BioCyci NHAL472759:GHH2-3489-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.110. 1 hit.
    3.30.70.150. 1 hit.
    HAMAPi MF_01338. RuBisCO_L_type1.
    InterProi IPR020878. RuBisCo_large_chain_AS.
    IPR020888. RuBisCO_lsu.
    IPR000685. RuBisCO_lsu_C.
    IPR017443. RuBisCO_lsu_fd_N.
    IPR017444. RuBisCO_lsu_N.
    [Graphical view ]
    Pfami PF00016. RuBisCO_large. 1 hit.
    PF02788. RuBisCO_large_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51649. SSF51649. 1 hit.
    SSF54966. SSF54966. 1 hit.
    PROSITEi PS00157. RUBISCO_LARGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Nitrosococcus halophilus Nc4, a salt-adapted, aerobic obligate ammonia-oxidizing sulfur purple bacterium."
      US DOE Joint Genome Institute
      Campbell M.A., Malfatti S.A., Chain P.S.G., Heidelberg J.F., Ward B.B., Klotz M.G.
      Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nc4Imported.

    Entry informationi

    Entry nameiD5C1B7_NITHN
    AccessioniPrimary (citable) accession number: D5C1B7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel".UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3