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D5BUA8

- D5BUA8_PUNMI

UniProt

D5BUA8 - D5BUA8_PUNMI

Protein

Thymidine kinase

Gene

tdk

Organism
Puniceispirillum marinum (strain IMCC1322)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei93 – 931Proton acceptorUniRule annotation
    Metal bindingi150 – 1501ZincUniRule annotation
    Metal bindingi152 – 1521ZincUniRule annotation
    Metal bindingi187 – 1871ZincUniRule annotation
    Metal bindingi190 – 1901ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 168ATPUniRule annotation
    Nucleotide bindingi92 – 954ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciPMAR488538:GI1I-1634-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:SAR116_1612Imported
    OrganismiPuniceispirillum marinum (strain IMCC1322)Imported
    Taxonomic identifieri488538 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR116 clusterCandidatus Puniceispirillum
    ProteomesiUP000007460: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD5BUA8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000076391.
    KOiK00857.
    OMAiELKTVCH.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D5BUA8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKLYFSYSA MNAGKSTILL QASHNYKERG MNTVLLTARL DDRIGQGEDG    50
    KGKIGSRIGL QADAEMFDDS TDIFALATEL SRDSDIACIM VDEAQFLTIA 100
    QVWQLSAIAD ELGIPVMCYG LRTDFQGQLF DGSATLLAIA DVLREIRTIC 150
    HCGRKATMVV RQDADGKPIT DGAQIEIGGN DKYVSLCRRH WKAAMAKVAE 200
    SD 202
    Length:202
    Mass (Da):22,075
    Last modified:June 15, 2010 - v1
    Checksum:i9E4F3B0FCD246196
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001751 Genomic DNA. Translation: ADE39855.1.
    RefSeqiYP_003551939.1. NC_014010.1.

    Genome annotation databases

    EnsemblBacteriaiADE39855; ADE39855; SAR116_1612.
    GeneIDi8961949.
    KEGGiapb:SAR116_1612.
    PATRICi35450195. VBIAlpPro78664_1632.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001751 Genomic DNA. Translation: ADE39855.1 .
    RefSeqi YP_003551939.1. NC_014010.1.

    3D structure databases

    ProteinModelPortali D5BUA8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADE39855 ; ADE39855 ; SAR116_1612 .
    GeneIDi 8961949.
    KEGGi apb:SAR116_1612.
    PATRICi 35450195. VBIAlpPro78664_1632.

    Phylogenomic databases

    HOGENOMi HOG000076391.
    KOi K00857.
    OMAi ELKTVCH.

    Enzyme and pathway databases

    BioCyci PMAR488538:GI1I-1634-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of "Candidatus Puniceispirillum marinum" IMCC1322, a representative of the SAR116 clade in the Alphaproteobacteria."
      Oh H.M., Kwon K.K., Kang I., Kang S.G., Lee J.H., Kim S.J., Cho J.C.
      J. Bacteriol. 192:3240-3241(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IMCC1322Imported.

    Entry informationi

    Entry nameiD5BUA8_PUNMI
    AccessioniPrimary (citable) accession number: D5BUA8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3