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Protein

Thymidine kinase

Gene

tdk

Organism
Puniceispirillum marinum (strain IMCC1322)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei93 – 931Proton acceptorUniRule annotation
Metal bindingi150 – 1501ZincUniRule annotation
Metal bindingi152 – 1521ZincUniRule annotation
Metal bindingi187 – 1871ZincUniRule annotation
Metal bindingi190 – 1901ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi92 – 954ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciPMAR488538:GI1I-1634-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:SAR116_1612Imported
OrganismiPuniceispirillum marinum (strain IMCC1322)Imported
Taxonomic identifieri488538 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR116 clusterCandidatus Puniceispirillum
ProteomesiUP000007460 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD5BUA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiRATHNAR.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5BUA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLYFSYSA MNAGKSTILL QASHNYKERG MNTVLLTARL DDRIGQGEDG
60 70 80 90 100
KGKIGSRIGL QADAEMFDDS TDIFALATEL SRDSDIACIM VDEAQFLTIA
110 120 130 140 150
QVWQLSAIAD ELGIPVMCYG LRTDFQGQLF DGSATLLAIA DVLREIRTIC
160 170 180 190 200
HCGRKATMVV RQDADGKPIT DGAQIEIGGN DKYVSLCRRH WKAAMAKVAE

SD
Length:202
Mass (Da):22,075
Last modified:June 15, 2010 - v1
Checksum:i9E4F3B0FCD246196
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001751 Genomic DNA. Translation: ADE39855.1.
RefSeqiWP_013046482.1. NC_014010.1.
YP_003551939.1. NC_014010.1.

Genome annotation databases

EnsemblBacteriaiADE39855; ADE39855; SAR116_1612.
KEGGiapb:SAR116_1612.
PATRICi35450195. VBIAlpPro78664_1632.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001751 Genomic DNA. Translation: ADE39855.1.
RefSeqiWP_013046482.1. NC_014010.1.
YP_003551939.1. NC_014010.1.

3D structure databases

ProteinModelPortaliD5BUA8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADE39855; ADE39855; SAR116_1612.
KEGGiapb:SAR116_1612.
PATRICi35450195. VBIAlpPro78664_1632.

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiRATHNAR.

Enzyme and pathway databases

BioCyciPMAR488538:GI1I-1634-MONOMER.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of "Candidatus Puniceispirillum marinum" IMCC1322, a representative of the SAR116 clade in the Alphaproteobacteria."
    Oh H.M., Kwon K.K., Kang I., Kang S.G., Lee J.H., Kim S.J., Cho J.C.
    J. Bacteriol. 192:3240-3241(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IMCC1322Imported.

Entry informationi

Entry nameiD5BUA8_PUNMI
AccessioniPrimary (citable) accession number: D5BUA8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: May 27, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.