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Protein

Alanine racemase

Gene

SAR116_0646

Organism
Puniceispirillum marinum (strain IMCC1322)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei48 – 481Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei151 – 1511SubstrateUniRule annotation
Active sitei278 – 2781Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei326 – 3261Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPMAR488538:GI1I-659-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:SAR116_0646Imported
OrganismiPuniceispirillum marinum (strain IMCC1322)Imported
Taxonomic identifieri488538 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR116 clusterCandidatus Puniceispirillum
ProteomesiUP000007460 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 481N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD5BRJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031445.
KOiK01775.
OMAiDAGTISY.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

D5BRJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGDENVLA AFGAADNRID IDLGAIAHNW LYLDSLSPKS TITAAMVKAN
60 70 80 90 100
GYGLGANHVG AALYKAGCRQ FFVANLDEAV SFRTYLDNIS ISDAQIMVLH
110 120 130 140 150
GCHRGQEHDM RAYRLTPVLN DLEQVSRWRL YAQNANETYP AMLHLDTGMT
160 170 180 190 200
RLGFDPDQTD WLIENKQALN GLEITYIMSH LISGEISDDP ANTAQKTRFD
210 220 230 240 250
EYRSFFGGIK ASLANSGGVF LGNEFHYQMT RPGIAIYGVH PCGKDQAITD
260 270 280 290 300
SNGLKSCITW HGRIIQVRTA PEGATVGYGG THRLSRPSRI ATVGVGYADG
310 320 330 340 350
YQRNLSNKAF VNILGHRAPV IGRISMDSIT IDVTDIPPNI MLKAETAALL
360 370 380
SDLYSIEDMA NDASTIPYEI LTGISRRAIR RYI
Length:383
Mass (Da):42,040
Last modified:June 15, 2010 - v1
Checksum:iC94F1188C70B9228
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001751 Genomic DNA. Translation: ADE38889.1.
RefSeqiYP_003550973.1. NC_014010.1.

Genome annotation databases

EnsemblBacteriaiADE38889; ADE38889; SAR116_0646.
KEGGiapb:SAR116_0646.
PATRICi35448201. VBIAlpPro78664_0646.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001751 Genomic DNA. Translation: ADE38889.1.
RefSeqiYP_003550973.1. NC_014010.1.

3D structure databases

ProteinModelPortaliD5BRJ2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADE38889; ADE38889; SAR116_0646.
KEGGiapb:SAR116_0646.
PATRICi35448201. VBIAlpPro78664_0646.

Phylogenomic databases

HOGENOMiHOG000031445.
KOiK01775.
OMAiDAGTISY.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciPMAR488538:GI1I-659-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of "Candidatus Puniceispirillum marinum" IMCC1322, a representative of the SAR116 clade in the Alphaproteobacteria."
    Oh H.M., Kwon K.K., Kang I., Kang S.G., Lee J.H., Kim S.J., Cho J.C.
    J. Bacteriol. 192:3240-3241(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IMCC1322Imported.

Entry informationi

Entry nameiD5BRJ2_PUNMI
AccessioniPrimary (citable) accession number: D5BRJ2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: April 1, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.