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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

SAR116_0207

Organism
Puniceispirillum marinum (strain IMCC1322)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • (R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation
  • (R)-lipoateUniRule annotationNote: Binds 2 lipoyl cofactors covalently.UniRule annotation
  • (R)-lipoateUniRule annotationNote: Binds 3 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyruvate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotationImported, Transferase

Enzyme and pathway databases

BioCyciPMAR488538:GI1I-213-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Ordered Locus Names:SAR116_0207Imported
OrganismiPuniceispirillum marinum (strain IMCC1322)Imported
Taxonomic identifieri488538 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR116 clusterCandidatus Puniceispirillum
ProteomesiUP000007460: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000281566.
KOiK00627.
OMAiATMEFES.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5BPG8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIEIKMPAL SPTMEVGTLS KWMVAVGDDV RSGDVIAEIE TDKATMEVEA
60 70 80 90 100
VDDGKMAQIA VADGTENIPV GTVIALLAED GEDVATVSSA SPKPAASKLA
110 120 130 140 150
PPKEDAAGEE SGSAAKEAVA DDATKQEPAM DTSKPAPVSP RTSADTKRIF
160 170 180 190 200
ASPLARRIAA DKGVDLASLT GSGPHGRILR RDVEGAPASM QASLATTAPS
210 220 230 240 250
RAVTSSAEKG ASTLVPNNQM RKIIASRLQE SKQTAPHFYL TIDCNIDTLL
260 270 280 290 300
ESRKALNALA DEGIKISVND MVIRAAAMAL MKVPAANASW EGDNTRLFHN
310 320 330 340 350
ADICMAVAVD GGLVTPVIWA AESKGLSELS TISSDLATRA RDGKLAAEEF
360 370 380 390 400
TGGSFTISNL GMFGVREFAA VINPPQGAIL AVGAGEQRPV VIDGALSVAT
410 420 430
MMTVTLSCDH RAVDGAVGAE WLQAFKGFVE NPVTMLL
Length:437
Mass (Da):45,352
Last modified:June 15, 2010 - v1
Checksum:iC98F069881325B01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001751 Genomic DNA. Translation: ADE38450.1.
RefSeqiYP_003550534.1. NC_014010.1.

Genome annotation databases

EnsemblBacteriaiADE38450; ADE38450; SAR116_0207.
GeneIDi8960528.
KEGGiapb:SAR116_0207.
PATRICi35447301. VBIAlpPro78664_0204.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001751 Genomic DNA. Translation: ADE38450.1.
RefSeqiYP_003550534.1. NC_014010.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADE38450; ADE38450; SAR116_0207.
GeneIDi8960528.
KEGGiapb:SAR116_0207.
PATRICi35447301. VBIAlpPro78664_0204.

Phylogenomic databases

HOGENOMiHOG000281566.
KOiK00627.
OMAiATMEFES.

Enzyme and pathway databases

BioCyciPMAR488538:GI1I-213-MONOMER.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of "Candidatus Puniceispirillum marinum" IMCC1322, a representative of the SAR116 clade in the Alphaproteobacteria."
    Oh H.M., Kwon K.K., Kang I., Kang S.G., Lee J.H., Kim S.J., Cho J.C.
    J. Bacteriol. 192:3240-3241(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IMCC1322Imported.

Entry informationi

Entry nameiD5BPG8_PUNMI
AccessioniPrimary (citable) accession number: D5BPG8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: January 7, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.