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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

SAR116_0207

Organism
Puniceispirillum marinum (strain IMCC1322)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, Transferase

Enzyme and pathway databases

BioCyciCPUN488538:G1GG6-216-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Ordered Locus Names:SAR116_0207Imported
OrganismiPuniceispirillum marinum (strain IMCC1322)Imported
Taxonomic identifieri488538 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSAR116 clusterCandidatus Puniceispirillum
Proteomesi
  • UP000007460 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi488538.SAR116_0207

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 78Lipoyl-bindingInterPro annotationAdd BLAST77
Domaini150 – 187Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C7S Bacteria
COG0508 LUCA
HOGENOMiHOG000281566
KOiK00627
OMAiSWRLGCD
OrthoDBiPOG091H0NG1

Family and domain databases

Gene3Di3.30.559.101 hit
4.10.320.101 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR006257 LAT1
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 1 hit
TIGRFAMsiTIGR01349 PDHac_trf_mito, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00189 LIPOYL, 1 hit
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

D5BPG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIEIKMPAL SPTMEVGTLS KWMVAVGDDV RSGDVIAEIE TDKATMEVEA
60 70 80 90 100
VDDGKMAQIA VADGTENIPV GTVIALLAED GEDVATVSSA SPKPAASKLA
110 120 130 140 150
PPKEDAAGEE SGSAAKEAVA DDATKQEPAM DTSKPAPVSP RTSADTKRIF
160 170 180 190 200
ASPLARRIAA DKGVDLASLT GSGPHGRILR RDVEGAPASM QASLATTAPS
210 220 230 240 250
RAVTSSAEKG ASTLVPNNQM RKIIASRLQE SKQTAPHFYL TIDCNIDTLL
260 270 280 290 300
ESRKALNALA DEGIKISVND MVIRAAAMAL MKVPAANASW EGDNTRLFHN
310 320 330 340 350
ADICMAVAVD GGLVTPVIWA AESKGLSELS TISSDLATRA RDGKLAAEEF
360 370 380 390 400
TGGSFTISNL GMFGVREFAA VINPPQGAIL AVGAGEQRPV VIDGALSVAT
410 420 430
MMTVTLSCDH RAVDGAVGAE WLQAFKGFVE NPVTMLL
Length:437
Mass (Da):45,352
Last modified:June 15, 2010 - v1
Checksum:iC98F069881325B01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001751 Genomic DNA Translation: ADE38450.1
RefSeqiWP_013045080.1, NC_014010.1

Genome annotation databases

EnsemblBacteriaiADE38450; ADE38450; SAR116_0207
KEGGiapb:SAR116_0207

Similar proteinsi

Entry informationi

Entry nameiD5BPG8_PUNMI
AccessioniPrimary (citable) accession number: D5BPG8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: March 28, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported