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Protein

Alanine racemase

Gene

ZPR_4611

Organism
Zunongwangia profunda (strain DSM 18752 / CCTCC AB 206139 / SM-A87)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathway:iD-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (ZPR_4611)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei136 – 1361SubstrateUniRule annotation
Active sitei264 – 2641Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei313 – 3131Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciZPRO655815:GI6J-4606-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:ZPR_4611Imported
OrganismiZunongwangia profunda (strain DSM 18752 / CCTCC AB 206139 / SM-A87)Imported
Taxonomic identifieri655815 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeZunongwangia
ProteomesiUP000001654 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi655815.ZPR_4611.

Structurei

3D structure databases

ProteinModelPortaliD5BDK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiFCRRTGW.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

D5BDK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKAQETVLE IDLKSLEHNY QYLRSKVEPT VKMMAVVKAF AYGSDSVTIA
60 70 80 90 100
AKLEKAGIDH FAVAYTKEGE TLRAGGIEKP VLVLHPQPHN LTLLIDNCLT
110 120 130 140 150
PSLYSKHILT EFIKTAEALK LKEYPVHINI NTGLNRLGFG LEEIDQVITL
160 170 180 190 200
FKNTLAVRLV GIYSHLAASE DLAEKEFTQG QIETFKKASG KILKAFDHKI
210 220 230 240 250
MRHLCNTSGI LNYPEATFDM VRTGIGLYGY GNSAQEDKKL KPVGTLKTII
260 270 280 290 300
SQIHNIKAEE SVGYNRAFIA KRDTTTATLP IGHADGISRI YGKQKTAVLI
310 320 330 340 350
NDKEAPIIGN VCMDMIMVDV TGIECKEGDQ VIIFGKERSA EKLANNAGTI
360
SYELITSISQ RVKRLIID
Length:368
Mass (Da):40,705
Last modified:June 15, 2010 - v1
Checksum:i227669E445C523E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001650 Genomic DNA. Translation: ADF54911.1.
RefSeqiWP_013073971.1. NC_014041.1.

Genome annotation databases

EnsemblBacteriaiADF54911; ADF54911; ZPR_4611.
KEGGizpr:ZPR_4611.
PATRICi37238526. VBIZunPro130839_4456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001650 Genomic DNA. Translation: ADF54911.1.
RefSeqiWP_013073971.1. NC_014041.1.

3D structure databases

ProteinModelPortaliD5BDK5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi655815.ZPR_4611.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADF54911; ADF54911; ZPR_4611.
KEGGizpr:ZPR_4611.
PATRICi37238526. VBIZunPro130839_4456.

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiFCRRTGW.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciZPRO655815:GI6J-4606-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete genome of Zunongwangia profunda SM-A87 reveals its adaptation to the deep-sea environment and ecological role in sedimentary organic nitrogen degradation."
    Qin Q.L., Zhang X.Y., Wang X.M., Liu G.M., Chen X.L., Xie B.B., Dang H.Y., Zhou B.C., Yu J., Zhang Y.Z.
    BMC Genomics 11:247-247(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 18752 / CCTCC AB 206139 / SM-A87Imported.

Entry informationi

Entry nameiD5BDK5_ZUNPS
AccessioniPrimary (citable) accession number: D5BDK5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: July 22, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.