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D5BA27 (D5BA27_ZUNPS) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Imidazole glycerol phosphate synthase subunit HisF HAMAP-Rule MF_01013
EC=4.1.3.- HAMAP-Rule MF_01013
Alternative name(s):
IGP synthase cyclase subunit HAMAP-Rule MF_01013
IGP synthase subunit HisF HAMAP-Rule MF_01013
ImGP synthase subunit HisF HAMAP-Rule MF_01013
Gene names
Name:hisF HAMAP-Rule MF_01013
Ordered Locus Names:ZPR_2000
OrganismZunongwangia profunda (strain DSM 18752 / CCTCC AB 206139 / SM-A87) [Complete proteome] [HAMAP]
Taxonomic identifier655815 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Zunongwangia ›

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit By similarity. HAMAP-Rule MF_01013 SAAS SAAS004651

Catalytic activity

5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H2O. HAMAP-Rule MF_01013 SAAS SAAS004651

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. HAMAP-Rule MF_01013 SAAS SAAS004651

Subunit structure

Heterodimer of HisH and HisF By similarity. HAMAP-Rule MF_01013 SAAS SAAS004651

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01013.

Sequence similarities

Belongs to the HisA/HisF family. HAMAP-Rule MF_01013 RuleBase RU003657

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site111 By similarity HAMAP-Rule MF_01013
Active site1301 By similarity HAMAP-Rule MF_01013

Sequences

Sequence LengthMass (Da)Tools
D5BA27 [UniParc].

Last modified June 15, 2010. Version 1.
Checksum: 241A86A8CC656D22

FASTA25127,208
        10         20         30         40         50         60 
MLTKRIIPCL DIKNGRTVKG VNFVDLRDAG DPVELASKYA ETGADELVFL DISATEERRK 

        70         80         90        100        110        120 
TLANLVLRVA EKVNIPFTVG GGISSIEDVD ILLKNGADKV SVNSSAVKNP DLINELSQKF 

       130        140        150        160        170        180 
GAQCITVAID AKQINGQWIV HLVGGKVPTE LDLFEWAKEV EQRGAGEILF TSMNNDGTKD 

       190        200        210        220        230        240 
GFANIALKKL SEDLNIPIIA SGGAGNIQHF VDTFKEGKAD AALAASVFHF KEIEIPELKK 

       250 
ELKKQGIPVR I

« Hide

References

[1]"The complete genome of Zunongwangia profunda SM-A87 reveals its adaptation to the deep-sea environment and ecological role in sedimentary organic nitrogen degradation."
Qin Q.L., Zhang X.Y., Wang X.M., Liu G.M., Chen X.L., Xie B.B., Dang H.Y., Zhou B.C., Yu J., Zhang Y.Z.
BMC Genomics 11:247-247(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 18752 / CCTCC AB 206139 / SM-A87.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001650 Genomic DNA. Translation: ADF52325.1.
RefSeqYP_003584521.1. NC_014041.1.

3D structure databases

ProteinModelPortalD5BA27.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADF52325; ADF52325; ZPR_2000.
GeneID9077872.
KEGGzpr:ZPR_2000.
PATRIC37233401. VBIZunPro130839_1918.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000224612.
KOK02500.
OMARVVKGTN.

Enzyme and pathway databases

UniPathwayUPA00031; UER00010.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01013. HisF.
InterProIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR004651. HisF.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMSSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMsTIGR00735. hisF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD5BA27_ZUNPS
AccessionPrimary (citable) accession number: D5BA27
Entry history
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: May 1, 2013
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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