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D5AW13

- D5AW13_RICPP

UniProt

D5AW13 - D5AW13_RICPP

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Protein

Alanine racemase

Gene
alr, rpr22_CDS089
Organism
Rickettsia prowazekii (strain Rp22)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei133 – 1331Substrate By similarityUniRule annotation
Active sitei298 – 2981Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei346 – 3461Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciRPRO449216:GLJI-94-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:rpr22_CDS089Imported
OrganismiRickettsia prowazekii (strain Rp22)Imported
Taxonomic identifieri449216 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000006931: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD5AW13.

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiRIGISIY.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
IPR005728. Rickett_RPE.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01045. RPE1. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5AW13-1 [UniParc]FASTAAdd to Basket

« Hide

MSLCTLEINL SAIKNNYRLL QDICKTALVG AVVKANGYGL GAMQIAKALI    50
KENCQYFFVA TSEEGINLRK VLNNDITILV LNGVFTHDAL ELIQYNLTPV 100
LNNLSQIEIW QKFSNLKGKI LPCYLHFNTG LNRFGLNSDE IEQLINDRDL 150
LKGLDLQYII SHLAASEETG NPYNLIQLNR FKVYLEYFPN VKASFANSGG 200
IFLGQDYHFD LARPGAALYG LNSLIEVSSN LSYTEEFESN TAALTTTACI 250
NKCPDVSVRL TPKLPLKGSH TVRLQNPVTL KAPIIDLQNL TLDSHIGYNM 300
TFTTKRDSVI ATLPLGYADG FSRNFSSQGE VFINSCSVPI VGRVSMDLIN 350
IDVTDLPPSE VFLGQEAEII GNYCTPDKIA SIIGTIGYEV LTSLGSRYKR 400
KYIS 404
Length:404
Mass (Da):44,704
Last modified:June 15, 2010 - v1
Checksum:iEBB73D867C97597F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001584 Genomic DNA. Translation: ADE29602.1.
RefSeqiYP_005998500.1. NC_017560.1.

Genome annotation databases

EnsemblBacteriaiADE29602; ADE29602; rpr22_CDS089.
GeneIDi12587846.
KEGGirpq:rpr22_CDS089.
PATRICi36792834. VBIRicPro89493_0092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001584 Genomic DNA. Translation: ADE29602.1 .
RefSeqi YP_005998500.1. NC_017560.1.

3D structure databases

ProteinModelPortali D5AW13.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADE29602 ; ADE29602 ; rpr22_CDS089 .
GeneIDi 12587846.
KEGGi rpq:rpr22_CDS089.
PATRICi 36792834. VBIRicPro89493_0092.

Phylogenomic databases

KOi K01775.
OMAi RIGISIY.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci RPRO449216:GLJI-94-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
IPR005728. Rickett_RPE.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01045. RPE1. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic, proteomic, and transcriptomic analysis of virulent and avirulent Rickettsia prowazekii reveals its adaptive mutation capabilities."
    Bechah Y., El Karkouri K., Mediannikov O., Leroy Q., Pelletier N., Robert C., Medigue C., Mege J.L., Raoult D.
    Genome Res. 20:655-663(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rp22Imported.

Entry informationi

Entry nameiD5AW13_RICPP
AccessioniPrimary (citable) accession number: D5AW13
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: July 9, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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