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Protein

Alanine racemase

Gene

alr

Organism
Rickettsia prowazekii (strain Rp22)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei133 – 1331SubstrateUniRule annotation
Active sitei298 – 2981Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei346 – 3461Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciRPRO449216:GLJI-94-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotationSAAS annotation (EC:5.1.1.1UniRule annotationSAAS annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:rpr22_CDS089Imported
OrganismiRickettsia prowazekii (strain Rp22)Imported
Taxonomic identifieri449216 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000006931: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD5AW13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiWKGGAAI.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
IPR005728. Rickett_RPE.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01045. RPE1. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5AW13-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLCTLEINL SAIKNNYRLL QDICKTALVG AVVKANGYGL GAMQIAKALI
60 70 80 90 100
KENCQYFFVA TSEEGINLRK VLNNDITILV LNGVFTHDAL ELIQYNLTPV
110 120 130 140 150
LNNLSQIEIW QKFSNLKGKI LPCYLHFNTG LNRFGLNSDE IEQLINDRDL
160 170 180 190 200
LKGLDLQYII SHLAASEETG NPYNLIQLNR FKVYLEYFPN VKASFANSGG
210 220 230 240 250
IFLGQDYHFD LARPGAALYG LNSLIEVSSN LSYTEEFESN TAALTTTACI
260 270 280 290 300
NKCPDVSVRL TPKLPLKGSH TVRLQNPVTL KAPIIDLQNL TLDSHIGYNM
310 320 330 340 350
TFTTKRDSVI ATLPLGYADG FSRNFSSQGE VFINSCSVPI VGRVSMDLIN
360 370 380 390 400
IDVTDLPPSE VFLGQEAEII GNYCTPDKIA SIIGTIGYEV LTSLGSRYKR

KYIS
Length:404
Mass (Da):44,704
Last modified:June 15, 2010 - v1
Checksum:iEBB73D867C97597F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001584 Genomic DNA. Translation: ADE29602.1.
RefSeqiWP_014607182.1. NC_017560.1.
YP_005998500.1. NC_017560.1.

Genome annotation databases

EnsemblBacteriaiADE29602; ADE29602; rpr22_CDS089.
GeneIDi12587846.
KEGGirpq:rpr22_CDS089.
PATRICi36792834. VBIRicPro89493_0092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001584 Genomic DNA. Translation: ADE29602.1.
RefSeqiWP_014607182.1. NC_017560.1.
YP_005998500.1. NC_017560.1.

3D structure databases

ProteinModelPortaliD5AW13.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADE29602; ADE29602; rpr22_CDS089.
GeneIDi12587846.
KEGGirpq:rpr22_CDS089.
PATRICi36792834. VBIRicPro89493_0092.

Phylogenomic databases

KOiK01775.
OMAiWKGGAAI.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciRPRO449216:GLJI-94-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
IPR005728. Rickett_RPE.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01045. RPE1. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic, proteomic, and transcriptomic analysis of virulent and avirulent Rickettsia prowazekii reveals its adaptive mutation capabilities."
    Bechah Y., El Karkouri K., Mediannikov O., Leroy Q., Pelletier N., Robert C., Medigue C., Mege J.L., Raoult D.
    Genome Res. 20:655-663(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rp22Imported.

Entry informationi

Entry nameiD5AW13_RICPP
AccessioniPrimary (citable) accession number: D5AW13
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: February 4, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.