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D5AW13

- D5AW13_RICPP

UniProt

D5AW13 - D5AW13_RICPP

Protein

Alanine racemase

Gene

alr

Organism
Rickettsia prowazekii (strain Rp22)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei34 – 341Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei133 – 1331SubstrateUniRule annotation
    Active sitei298 – 2981Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei346 – 3461Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciRPRO449216:GLJI-94-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:rpr22_CDS089Imported
    OrganismiRickettsia prowazekii (strain Rp22)Imported
    Taxonomic identifieri449216 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000006931: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei34 – 341N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD5AW13.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.
    OMAiRIGISIY.

    Family and domain databases

    Gene3Di2.40.37.10. 2 hits.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    IPR005728. Rickett_RPE.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR01045. RPE1. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D5AW13-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLCTLEINL SAIKNNYRLL QDICKTALVG AVVKANGYGL GAMQIAKALI    50
    KENCQYFFVA TSEEGINLRK VLNNDITILV LNGVFTHDAL ELIQYNLTPV 100
    LNNLSQIEIW QKFSNLKGKI LPCYLHFNTG LNRFGLNSDE IEQLINDRDL 150
    LKGLDLQYII SHLAASEETG NPYNLIQLNR FKVYLEYFPN VKASFANSGG 200
    IFLGQDYHFD LARPGAALYG LNSLIEVSSN LSYTEEFESN TAALTTTACI 250
    NKCPDVSVRL TPKLPLKGSH TVRLQNPVTL KAPIIDLQNL TLDSHIGYNM 300
    TFTTKRDSVI ATLPLGYADG FSRNFSSQGE VFINSCSVPI VGRVSMDLIN 350
    IDVTDLPPSE VFLGQEAEII GNYCTPDKIA SIIGTIGYEV LTSLGSRYKR 400
    KYIS 404
    Length:404
    Mass (Da):44,704
    Last modified:June 15, 2010 - v1
    Checksum:iEBB73D867C97597F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001584 Genomic DNA. Translation: ADE29602.1.
    RefSeqiYP_005998500.1. NC_017560.1.

    Genome annotation databases

    EnsemblBacteriaiADE29602; ADE29602; rpr22_CDS089.
    GeneIDi12587846.
    KEGGirpq:rpr22_CDS089.
    PATRICi36792834. VBIRicPro89493_0092.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001584 Genomic DNA. Translation: ADE29602.1 .
    RefSeqi YP_005998500.1. NC_017560.1.

    3D structure databases

    ProteinModelPortali D5AW13.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADE29602 ; ADE29602 ; rpr22_CDS089 .
    GeneIDi 12587846.
    KEGGi rpq:rpr22_CDS089.
    PATRICi 36792834. VBIRicPro89493_0092.

    Phylogenomic databases

    KOi K01775.
    OMAi RIGISIY.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci RPRO449216:GLJI-94-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 2 hits.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    IPR005728. Rickett_RPE.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR01045. RPE1. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic, proteomic, and transcriptomic analysis of virulent and avirulent Rickettsia prowazekii reveals its adaptive mutation capabilities."
      Bechah Y., El Karkouri K., Mediannikov O., Leroy Q., Pelletier N., Robert C., Medigue C., Mege J.L., Raoult D.
      Genome Res. 20:655-663(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Rp22Imported.

    Entry informationi

    Entry nameiD5AW13_RICPP
    AccessioniPrimary (citable) accession number: D5AW13
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3