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D5AIJ2 (D5AIJ2_STRGZ) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:SSGZ1_1200 EMBL ADE31657.1
OrganismStreptococcus suis (strain GZ1) [Complete proteome] [HAMAP] EMBL ADE31657.1
Taxonomic identifier423211 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain150 – 341192ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding180 – 23556ATP By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D5AIJ2 [UniParc].

Last modified June 15, 2010. Version 1.
Checksum: 142B2BB529204EDD

FASTA34137,855
        10         20         30         40         50         60 
MLNYAILRVI ALIQEGKYMS KETLILLYGG RSAEREVSVL SAESVMRAIN YDKFFVKTYF 

        70         80         90        100        110        120 
ISQTGDFIKT QEFSQTPSAD EKLMTNATIV EEQKIRPSDI YEEKAVVFPV LHGPMGEDGS 

       130        140        150        160        170        180 
IQGFLEVLRM PYVGTNILSS SVAMDKITTK RVLESAGISQ VPYVAVIEGE NIDDKIAEIE 

       190        200        210        220        230        240 
GKLTYPVFVK PANMGSSVGI SKAEDLAGLR KALDLAFKYD SRVLVEQGVN AREIEVGLLG 

       250        260        270        280        290        300 
NADVKTTLPG EVVKDVAFYD YDAKYIDNKI TMEIPAKIDE SIMDIMRDNA AKAFRAIGGC 

       310        320        330        340 
GLSRCDFFPL FSLLSKKMVS YCFLVASIYT DCLPLYLVYR S 

« Hide

References

[1]"Clinical, experimental, and genomic differences between intermediately pathogenic, highly pathogenic, and epidemic Streptococcus suis."
Ye C., Zheng H., Zhang J., Jing H., Wang L., Xiong Y., Wang W., Zhou Z., Sun Q., Luo X., Du H., Gottschalk M., Xu J.
J. Infect. Dis. 199:97-107(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GZ1 EMBL ADE31657.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000837 Genomic DNA. Translation: ADE31657.1.
RefSeqYP_006074599.1. NC_017617.1.

3D structure databases

ProteinModelPortalD5AIJ2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADE31657; ADE31657; SSGZ1_1200.
GeneID12724603.
KEGGssw:SSGZ1_1200.
PATRIC36797001. VBIStrSui127079_1181.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011593.
KOK01921.

Enzyme and pathway databases

BioCycSSUI423211:GLLL-1251-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD5AIJ2_STRGZ
AccessionPrimary (citable) accession number: D5AIJ2
Entry history
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: February 19, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)