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D5AHG8

- D5AHG8_STRGZ

UniProt

D5AHG8 - D5AHG8_STRGZ

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Protein
Thymidine kinase
Gene
tdk, SSGZ1_0826
Organism
Streptococcus suis (strain GZ1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton acceptor By similarityUniRule annotation
Metal bindingi143 – 1431Zinc By similarityUniRule annotation
Metal bindingi146 – 1461Zinc By similarityUniRule annotation
Metal bindingi180 – 1801Zinc By similarityUniRule annotation
Metal bindingi183 – 1831Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarityUniRule annotation
Nucleotide bindingi85 – 884ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciSSUI423211:GLLL-877-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:SSGZ1_0826Imported
OrganismiStreptococcus suis (strain GZ1)Imported
Taxonomic identifieri423211 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002359: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliD5AHG8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D5AHG8-1 [UniParc]FASTAAdd to Basket

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MAQLYYKYGT MNSGKTIEIL KVAHNYEEQG KPVVIMTSAL DTRDAFGVVS    50
SRIGMRRDAV AIDDDMDIFG FIEKMEPRPY CVLIDEAQFL RRHHVYALAR 100
VVDELDVPVM AFGLKNDFRN ELFEGSQHLL LLADKLDEIK TICQYCSKKA 150
TMVLRTQDGK PTYEGEQIQI GGNETYIPVC RKHYFSPEIK DLP 193
Length:193
Mass (Da):22,105
Last modified:June 15, 2010 - v1
Checksum:iBE3F491F4155E359
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000837 Genomic DNA. Translation: ADE31283.1.
RefSeqiYP_006074225.1. NC_017617.1.

Genome annotation databases

EnsemblBacteriaiADE31283; ADE31283; SSGZ1_0826.
GeneIDi12724229.
KEGGissw:SSGZ1_0826.
PATRICi36796261. VBIStrSui127079_0811.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000837 Genomic DNA. Translation: ADE31283.1 .
RefSeqi YP_006074225.1. NC_017617.1.

3D structure databases

ProteinModelPortali D5AHG8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADE31283 ; ADE31283 ; SSGZ1_0826 .
GeneIDi 12724229.
KEGGi ssw:SSGZ1_0826.
PATRICi 36796261. VBIStrSui127079_0811.

Phylogenomic databases

HOGENOMi HOG000076391.
KOi K00857.

Enzyme and pathway databases

BioCyci SSUI423211:GLLL-877-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Clinical, experimental, and genomic differences between intermediately pathogenic, highly pathogenic, and epidemic Streptococcus suis."
    Ye C., Zheng H., Zhang J., Jing H., Wang L., Xiong Y., Wang W., Zhou Z., Sun Q., Luo X., Du H., Gottschalk M., Xu J.
    J. Infect. Dis. 199:97-107(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GZ1Imported.

Entry informationi

Entry nameiD5AHG8_STRGZ
AccessioniPrimary (citable) accession number: D5AHG8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: June 11, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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