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Protein

Thymidine kinase

Gene

tdk

Organism
Shewanella violacea (strain JCM 10179 / CIP 106290 / LMG 19151 / DSS12)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Proton acceptorUniRule annotation
Metal bindingi145 – 1451ZincUniRule annotation
Metal bindingi147 – 1471ZincUniRule annotation
Metal bindingi182 – 1821ZincUniRule annotation
Metal bindingi185 – 1851ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi87 – 904ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciSVIO637905:GCRO-1302-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:SVI_1271Imported
OrganismiShewanella violacea (strain JCM 10179 / CIP 106290 / LMG 19151 / DSS12)Imported
Taxonomic identifieri637905 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002350 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi637905.SVI_1271.

Structurei

3D structure databases

ProteinModelPortaliD4ZHU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiRATHNAR.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4ZHU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLYFYYSA MNAGKSTSLL QSSYNYRERG MNTLVMTASI DDRYGVGKVS
60 70 80 90 100
SRIGIETDAQ VFGSNNDIAK MIAMAHEEQK LHCILIDESQ FLSKQQVKQL
110 120 130 140 150
TYVVDILDIP VLCYGLKTDF QGELFTGSQY LLAWSDKLVE LKTICHCGRK
160 170 180 190
ANMVLRLDDE GKPMREGEQV AIGGNESYES VCRKHFREFL WD
Length:192
Mass (Da):21,852
Last modified:June 15, 2010 - v1
Checksum:iB5AB99130979DB54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011177 Genomic DNA. Translation: BAJ01242.1.
RefSeqiWP_013050553.1. NC_014012.1.

Genome annotation databases

EnsemblBacteriaiBAJ01242; BAJ01242; SVI_1271.
KEGGisvo:SVI_1271.
PATRICi35458717. VBISheVio92117_1226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011177 Genomic DNA. Translation: BAJ01242.1.
RefSeqiWP_013050553.1. NC_014012.1.

3D structure databases

ProteinModelPortaliD4ZHU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi637905.SVI_1271.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAJ01242; BAJ01242; SVI_1271.
KEGGisvo:SVI_1271.
PATRICi35458717. VBISheVio92117_1226.

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiRATHNAR.

Enzyme and pathway databases

BioCyciSVIO637905:GCRO-1302-MONOMER.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence and comparative analysis of Shewanella violacea, a psychrophilic and piezophilic bacterium from deep sea floor sediments."
    Aono E., Baba T., Ara T., Nishi T., Nakamichi T., Inamoto E., Toyonaga H., Hasegawa M., Takai Y., Okumura Y., Baba M., Tomita M., Kato C., Oshima T., Nakasone K., Mori H.
    Mol. Biosyst. 6:1216-1226(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 10179 / CIP 106290 / LMG 19151 / DSS12Imported.

Entry informationi

Entry nameiD4ZHU3_SHEVD
AccessioniPrimary (citable) accession number: D4ZHU3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: July 22, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.