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Protein

Thymidine kinase

Gene

tdk

Organism
Sphingobium japonicum (strain NBRC 101211 / UT26S)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Proton acceptorUniRule annotation
Metal bindingi145 – 1451ZincUniRule annotation
Metal bindingi147 – 1471ZincUniRule annotation
Metal bindingi182 – 1821ZincUniRule annotation
Metal bindingi185 – 1851ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi87 – 904ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciSJAP452662:GHEL-1646-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:SJA_C1-16230Imported
OrganismiSphingobium japonicum (strain NBRC 101211 / UT26S)Imported
Taxonomic identifieri452662 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingobium
ProteomesiUP000007753 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi452662.SJA_C1-16230.

Structurei

3D structure databases

ProteinModelPortaliD4Z1H5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiFFEYGAM.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4Z1H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLYFYYSS MNAGKSTTLL QSSFNYRERG METMLWTAAI DDRYERGLIV
60 70 80 90 100
SRIGLEAKAH LFDAATDLFA PISAQHARRP LSCVLVDEAQ FLNAAQVWQL
110 120 130 140 150
AAVADRLAIP VLCYGIRTDF QGQLFEGSAA LLGLADTLTE IKTICECGRK
160 170 180 190
ATMNLRVDGE GRPIREGEQT EIGGNDRYVA LCRRHFVEKR SAR
Length:193
Mass (Da):21,575
Last modified:June 15, 2010 - v1
Checksum:iBEA66C9C299EAF42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010803 Genomic DNA. Translation: BAI96457.1.
RefSeqiWP_013039962.1. NC_014006.1.

Genome annotation databases

EnsemblBacteriaiBAI96457; BAI96457; SJA_C1-16230.
KEGGisjp:SJA_C1-16230.
PATRICi35435485. VBISphJap147895_1544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010803 Genomic DNA. Translation: BAI96457.1.
RefSeqiWP_013039962.1. NC_014006.1.

3D structure databases

ProteinModelPortaliD4Z1H5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi452662.SJA_C1-16230.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAI96457; BAI96457; SJA_C1-16230.
KEGGisjp:SJA_C1-16230.
PATRICi35435485. VBISphJap147895_1544.

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiFFEYGAM.

Enzyme and pathway databases

BioCyciSJAP452662:GHEL-1646-MONOMER.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the representative gamma-hexachlorocyclohexane-degrading bacterium Sphingobium japonicum UT26."
    Nagata Y., Ohtsubo Y., Endo R., Ichikawa N., Ankai A., Oguchi A., Fukui S., Fujita N., Tsuda M.
    J. Bacteriol. 192:5852-5853(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NBRC 101211 / UT26SImported.

Entry informationi

Entry nameiD4Z1H5_SPHJU
AccessioniPrimary (citable) accession number: D4Z1H5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2010
Last sequence update: June 15, 2010
Last modified: July 22, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.