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D4QFE7

- BGAL_BIFBI

UniProt

D4QFE7 - BGAL_BIFBI

Protein

Beta-galactosidase BbgII

Gene

bbgII

Organism
Bifidobacterium bifidum
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 16 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei122 – 1221SubstrateBy similarity
    Binding sitei160 – 1601SubstrateBy similarity
    Active sitei161 – 1611Proton donorBy similarity
    Active sitei320 – 3201NucleophileBy similarity
    Binding sitei328 – 3281SubstrateBy similarity

    GO - Molecular functioni

    1. beta-galactosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. galactose metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-galactosidase BbgII (EC:3.2.1.23)
    Short name:
    Beta-galBy similarity
    Gene namesi
    Name:bbgIIImported
    OrganismiBifidobacterium bifidum
    Taxonomic identifieri1681 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium

    Subcellular locationi

    GO - Cellular componenti

    1. beta-galactosidase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 689689Beta-galactosidase BbgIIPRO_0000407684Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliD4QFE7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni368 – 3714Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 42 family.Sequence Analysis

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    3.40.50.880. 1 hit.
    InterProiIPR013739. Beta_galactosidase_C.
    IPR013738. Beta_galactosidase_Trimer.
    IPR029062. Class_I_gatase-like.
    IPR003476. Glyco_hydro_42.
    IPR013529. Glyco_hydro_42_N.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF02449. Glyco_hydro_42. 1 hit.
    PF08533. Glyco_hydro_42C. 1 hit.
    PF08532. Glyco_hydro_42M. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001084. B-galactosidase. 1 hit.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF52317. SSF52317. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D4QFE7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKRRKHSWP QPLKGAESRL WYGGDYNPDQ WPEEVWDDDI RLMKKAGVNL    50
    VSVGIFSWAK IEPEEGKYDF DWLDRAIDKL GKAGIAVDLA SATASPPMWL 100
    TQAHPEVLWK DERGDTVWPG AREHWRPTSP VFREYALNLC RRMAEHYKGN 150
    PYVVAWHVSN EYGCHNRFDY SDDAMRAFQK WCKKRYKTID AVNEAWGTAF 200
    WAQHMNDFSE IIPPRYIGDG NFMNPGKLLD YKRFSSDALK ELYIAERDVL 250
    ESITPGLPLT TNFMVSAGGS MLDYDDWGAE VDFVSNDHYF TPGEAHFDEV 300
    AYAASLMDGI SRKEPWFQME HSTSAVNWRP INYRAEPGSV VRDSLAQVAM 350
    GADAICYFQW RQSKAGAEKW HSSMVPHAGE DSQIFRDVCE LGADLGRLSD 400
    EGLMGTKTVK SKVAVVFDYE SQWATEYTAN PTQQVDHWTE PLDWFRALAD 450
    NGITADVVPV RSDWDSYEIA VLPCVYLLSE ETSRRVREFV ANGGKLFVTY 500
    YTGLSDENDH IWLGGYPGSI RDVVGVRVEE FAPMGNDMPG ALDHLDLDNG 550
    TVAHDFADVI TSTADTSTVL ASYKAERWTG MNEVPAIVAN GYGDGRTVYV 600
    GCRLGRQGLA KSLPAMLGSM GLSDLAGDGR VLRVERADAA AANHFEFVFN 650
    RTHEPVTVDV EGEAIAASLA HVDDGRATID PTGVVVLRR 689
    Length:689
    Mass (Da):77,217
    Last modified:June 15, 2010 - v1
    Checksum:i886064A1622193CC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB542712 Genomic DNA. Translation: BAI94826.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB542712 Genomic DNA. Translation: BAI94826.1 .

    3D structure databases

    ProteinModelPortali D4QFE7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    3.40.50.880. 1 hit.
    InterProi IPR013739. Beta_galactosidase_C.
    IPR013738. Beta_galactosidase_Trimer.
    IPR029062. Class_I_gatase-like.
    IPR003476. Glyco_hydro_42.
    IPR013529. Glyco_hydro_42_N.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF02449. Glyco_hydro_42. 1 hit.
    PF08533. Glyco_hydro_42C. 1 hit.
    PF08532. Glyco_hydro_42M. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001084. B-galactosidase. 1 hit.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF52317. SSF52317. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cooperation of beta-galactosidase and beta-N-acetylhexosaminidase from bifidobacteria in assimilation of human milk oligosaccharides with type 2 structure."
      Miwa M., Horimoto T., Kiyohara M., Katayama T., Kitaoka M., Ashida H., Yamamoto K.
      Glycobiology 20:1402-1409(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DSM 20082 / JCM 1254 / KCTC 3440Imported.

    Entry informationi

    Entry nameiBGAL_BIFBI
    AccessioniPrimary (citable) accession number: D4QFE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3