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D4QFE7

- BGAL_BIFBI

UniProt

D4QFE7 - BGAL_BIFBI

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Protein

Beta-galactosidase BbgII

Gene

bbgII

Organism
Bifidobacterium bifidum
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei122 – 1221SubstrateBy similarity
Binding sitei160 – 1601SubstrateBy similarity
Active sitei161 – 1611Proton donorBy similarity
Active sitei320 – 3201NucleophileBy similarity
Binding sitei328 – 3281SubstrateBy similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. galactose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase BbgII (EC:3.2.1.23)
Short name:
Beta-galBy similarity
Gene namesi
Name:bbgIIImported
OrganismiBifidobacterium bifidum
Taxonomic identifieri1681 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium

Subcellular locationi

GO - Cellular componenti

  1. beta-galactosidase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 689689Beta-galactosidase BbgIIPRO_0000407684Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliD4QFE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni368 – 3714Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the glycosyl hydrolase 42 family.Sequence Analysis

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.40.50.880. 1 hit.
InterProiIPR013739. Beta_galactosidase_C.
IPR013738. Beta_galactosidase_Trimer.
IPR029062. Class_I_gatase-like.
IPR003476. Glyco_hydro_42.
IPR013529. Glyco_hydro_42_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02449. Glyco_hydro_42. 1 hit.
PF08533. Glyco_hydro_42C. 1 hit.
PF08532. Glyco_hydro_42M. 1 hit.
[Graphical view]
PIRSFiPIRSF001084. B-galactosidase. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52317. SSF52317. 1 hit.

Sequencei

Sequence statusi: Complete.

D4QFE7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKRRKHSWP QPLKGAESRL WYGGDYNPDQ WPEEVWDDDI RLMKKAGVNL
60 70 80 90 100
VSVGIFSWAK IEPEEGKYDF DWLDRAIDKL GKAGIAVDLA SATASPPMWL
110 120 130 140 150
TQAHPEVLWK DERGDTVWPG AREHWRPTSP VFREYALNLC RRMAEHYKGN
160 170 180 190 200
PYVVAWHVSN EYGCHNRFDY SDDAMRAFQK WCKKRYKTID AVNEAWGTAF
210 220 230 240 250
WAQHMNDFSE IIPPRYIGDG NFMNPGKLLD YKRFSSDALK ELYIAERDVL
260 270 280 290 300
ESITPGLPLT TNFMVSAGGS MLDYDDWGAE VDFVSNDHYF TPGEAHFDEV
310 320 330 340 350
AYAASLMDGI SRKEPWFQME HSTSAVNWRP INYRAEPGSV VRDSLAQVAM
360 370 380 390 400
GADAICYFQW RQSKAGAEKW HSSMVPHAGE DSQIFRDVCE LGADLGRLSD
410 420 430 440 450
EGLMGTKTVK SKVAVVFDYE SQWATEYTAN PTQQVDHWTE PLDWFRALAD
460 470 480 490 500
NGITADVVPV RSDWDSYEIA VLPCVYLLSE ETSRRVREFV ANGGKLFVTY
510 520 530 540 550
YTGLSDENDH IWLGGYPGSI RDVVGVRVEE FAPMGNDMPG ALDHLDLDNG
560 570 580 590 600
TVAHDFADVI TSTADTSTVL ASYKAERWTG MNEVPAIVAN GYGDGRTVYV
610 620 630 640 650
GCRLGRQGLA KSLPAMLGSM GLSDLAGDGR VLRVERADAA AANHFEFVFN
660 670 680
RTHEPVTVDV EGEAIAASLA HVDDGRATID PTGVVVLRR
Length:689
Mass (Da):77,217
Last modified:June 15, 2010 - v1
Checksum:i886064A1622193CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB542712 Genomic DNA. Translation: BAI94826.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB542712 Genomic DNA. Translation: BAI94826.1 .

3D structure databases

ProteinModelPortali D4QFE7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
3.40.50.880. 1 hit.
InterProi IPR013739. Beta_galactosidase_C.
IPR013738. Beta_galactosidase_Trimer.
IPR029062. Class_I_gatase-like.
IPR003476. Glyco_hydro_42.
IPR013529. Glyco_hydro_42_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF02449. Glyco_hydro_42. 1 hit.
PF08533. Glyco_hydro_42C. 1 hit.
PF08532. Glyco_hydro_42M. 1 hit.
[Graphical view ]
PIRSFi PIRSF001084. B-galactosidase. 1 hit.
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF52317. SSF52317. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cooperation of beta-galactosidase and beta-N-acetylhexosaminidase from bifidobacteria in assimilation of human milk oligosaccharides with type 2 structure."
    Miwa M., Horimoto T., Kiyohara M., Katayama T., Kitaoka M., Ashida H., Yamamoto K.
    Glycobiology 20:1402-1409(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 20082 / JCM 1254 / KCTC 3440Imported.

Entry informationi

Entry nameiBGAL_BIFBI
AccessioniPrimary (citable) accession number: D4QFE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: June 15, 2010
Last modified: October 1, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3