ID   D4N885_9BURK            Unreviewed;       134 AA.
AC   D4N885;
DT   18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT   18-MAY-2010, sequence version 1.
DT   03-MAY-2023, entry version 25.
DE   SubName: Full=ProFAR isomerase {ECO:0000313|EMBL:ADD60405.1};
DE   Flags: Fragment;
GN   Name=hisA {ECO:0000313|EMBL:ADD60405.1};
OS   Burkholderia diffusa.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=488732 {ECO:0000313|EMBL:ADD60405.1};
RN   [1] {ECO:0000313|EMBL:ADD60405.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=LMG 24267 {ECO:0000313|EMBL:ADD60405.1};
RA   Fani R., Papaleo M.C., Perrin E., Vandamme P., De Brandt E.;
RT   "The use of hisA sequence for the identification of Burkholderia strains.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
CC   -!- SIMILARITY: Belongs to the HisA/HisF family.
CC       {ECO:0000256|ARBA:ARBA00009667, ECO:0000256|RuleBase:RU003657}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GU130209; ADD60405.1; -; Genomic_DNA.
DR   AlphaFoldDB; D4N885; -.
DR   GO; GO:0003949; F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity; IEA:InterPro.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006062; His_biosynth.
DR   InterPro; IPR044524; Isoase_HisA-like.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR43090; 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE; 1.
DR   PANTHER; PTHR43090:SF2; 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE; 1.
DR   Pfam; PF00977; His_biosynth; 1.
DR   SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605,
KW   ECO:0000256|RuleBase:RU003657};
KW   Histidine biosynthesis {ECO:0000256|ARBA:ARBA00023102,
KW   ECO:0000256|RuleBase:RU003657}; Isomerase {ECO:0000313|EMBL:ADD60405.1}.
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ADD60405.1"
FT   NON_TER         134
FT                   /evidence="ECO:0000313|EMBL:ADD60405.1"
SQ   SEQUENCE   134 AA;  14331 MW;  4C45F546CC3483A5 CRC64;
     WVDLGARRLH LVDLNGAFAG KPKNLEAIEA ILDEVGDEIP VQLGGGIRSL ETIEKYLDAG
     LSYVIIGTAA VKNPGFLQDA CTAFSGNIIV GLDAKDGKVA TDGWSKLTGH EVIDLARKFE
     DYGVESIVYT DIGR
//