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D4IFZ5

- D4IFZ5_ERWAE

UniProt

D4IFZ5 - D4IFZ5_ERWAE

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Protein
D-alanine--D-alanine ligase
Gene
ddlB, ddl, EAM_0700
Organism
Erwinia amylovora (strain ATCC 49946 / CCPPB 0273 / Ea273 / 27-3)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi257 – 2571Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi270 – 2701Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi270 – 2701Magnesium or manganese 2 By similarityUniRule annotation
Metal bindingi272 – 2721Magnesium or manganese 2 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi134 – 18956ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciEAMY716540:GJAV-737-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddlBImported
Synonyms:ddlUniRule annotation
Ordered Locus Names:EAM_0700Imported
OrganismiErwinia amylovora (strain ATCC 49946 / CCPPB 0273 / Ea273 / 27-3)Imported
Taxonomic identifieri716540 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeErwinia
ProteomesiUP000008873: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliD4IFZ5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini101 – 303203ATP-grasp By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000011592.
KOiK01921.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4IFZ5-1 [UniParc]FASTAAdd to Basket

« Hide

MAEKVAVLLG GTSAERDVSL LSGTAVLKGL QEAGIDAYPV DIRDFPVTRL    50
KEEGFEKAFI ALHGRGGEDG TLQGVLEFLN IPYTGSGVMA SAITMDKLRS 100
KYLWQGCGLP VSPFVALTRA QMDAGLDAQV MASIDALGLP LFVKPSREGS 150
SVGISRVNQA SELQAALEEA FRFDHEVLVE AFLSGPEYTV GVLGTDILPS 200
IRIQTASEFY DYDAKYFSDE TQYFCPSGLS ADQEAELREL TISAWNALGC 250
SGWGRVDVMM GGDGRFYLLE VNTSPGMTSH SLVPMAAKQA GMSFSQLVAR 300
ILELAD 306
Length:306
Mass (Da):32,871
Last modified:May 18, 2010 - v1
Checksum:i18AB0D5C1256B093
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN666575 Genomic DNA. Translation: CBJ45375.1.
RefSeqiYP_003537790.1. NC_013971.1.

Genome annotation databases

EnsemblBacteriaiCBJ45375; CBJ45375; EAM_0700.
GeneIDi8951516.
KEGGieay:EAM_0700.
PATRICi35412817. VBIErwAmy154257_0677.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN666575 Genomic DNA. Translation: CBJ45375.1 .
RefSeqi YP_003537790.1. NC_013971.1.

3D structure databases

ProteinModelPortali D4IFZ5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBJ45375 ; CBJ45375 ; EAM_0700 .
GeneIDi 8951516.
KEGGi eay:EAM_0700.
PATRICi 35412817. VBIErwAmy154257_0677.

Phylogenomic databases

HOGENOMi HOG000011592.
KOi K01921.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci EAMY716540:GJAV-737-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49946 / CCPPB 0273 / Ea273 / 27-3.

Entry informationi

Entry nameiD4IFZ5_ERWAE
AccessioniPrimary (citable) accession number: D4IFZ5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 18, 2010
Last sequence update: May 18, 2010
Last modified: June 11, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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