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Protein

Deoxyribose-phosphate aldolase

Gene

deoC

Organism
Erwinia amylovora (strain ATCC 49946 / CCPPB 0273 / Ea273 / 27-3)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.UniRule annotationSAAS annotation

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei167 – 1671Schiff-base intermediate with acetaldehydeUniRule annotation
Active sitei201 – 2011UniRule annotation

GO - Molecular functioni

  1. deoxyribose-phosphate aldolase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate catabolic process Source: UniProtKB-HAMAP
  2. deoxyribonucleotide catabolic process Source: InterPro
  3. deoxyribose phosphate catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Ligandi

Schiff baseUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciEAMY716540:GJAV-652-MONOMER.
UniPathwayiUPA00002; UER00468.
UPA00002; UER00468.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolaseUniRule annotationSAAS annotation (EC:4.1.2.4UniRule annotationSAAS annotation)
Short name:
DERAUniRule annotation
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolaseUniRule annotation
PhosphodeoxyriboaldolaseUniRule annotation
Gene namesi
Name:deoCUniRule annotationImported
Ordered Locus Names:EAM_0615Imported
OrganismiErwinia amylovora (strain ATCC 49946 / CCPPB 0273 / Ea273 / 27-3)Imported
Taxonomic identifieri716540 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeErwinia
ProteomesiUP000008873: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD4IFW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000241644.
KOiK01619.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00592. DeoC_type2.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR023649. DeoC_typeII.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
TIGRFAMsiTIGR00126. deoC. 1 hit.

Sequencei

Sequence statusi: Complete.

D4IFW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDVKTQALR ALQLMDLTTL NDDDTDAKVL ALCRQAKSPA GNTAAICIYP
60 70 80 90 100
RFIPLARKTL REQGTPEIRI ATVTNFPHGN DDIEIALAET RAAIAYGADE
110 120 130 140 150
VDVVFPYRAL MAGNGTVGFE LVKACKQACS AANVLLKVII ESGELKEDAL
160 170 180 190 200
IRQASEIAID AGADFIKTST GKVPVNATPA VAEIMMRTIA AKGVHQQVGF
210 220 230 240 250
KPAGGVRTAE EAALYLQLAD DILGPDWADA RHFRFGASSL LASLLNAAGF

NSAASDSSY
Length:259
Mass (Da):27,438
Last modified:May 18, 2010 - v1
Checksum:i0DB4E1AF395D6F96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN666575 Genomic DNA. Translation: CBJ45290.1.
RefSeqiYP_003537705.1. NC_013971.1.

Genome annotation databases

EnsemblBacteriaiCBJ45290; CBJ45290; EAM_0615.
GeneIDi8949116.
KEGGieay:EAM_0615.
PATRICi35412647. VBIErwAmy154257_0592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN666575 Genomic DNA. Translation: CBJ45290.1.
RefSeqiYP_003537705.1. NC_013971.1.

3D structure databases

ProteinModelPortaliD4IFW2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBJ45290; CBJ45290; EAM_0615.
GeneIDi8949116.
KEGGieay:EAM_0615.
PATRICi35412647. VBIErwAmy154257_0592.

Phylogenomic databases

HOGENOMiHOG000241644.
KOiK01619.

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468.
UPA00002; UER00468.
BioCyciEAMY716540:GJAV-652-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00592. DeoC_type2.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR023649. DeoC_typeII.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
TIGRFAMsiTIGR00126. deoC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49946 / CCPPB 0273 / Ea273 / 27-3Imported.

Entry informationi

Entry nameiD4IFW2_ERWAE
AccessioniPrimary (citable) accession number: D4IFW2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 18, 2010
Last sequence update: May 18, 2010
Last modified: March 4, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.