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Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Erwinia amylovora (strain CFBP1430)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotationSAAS annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotationSAAS annotation

Pathwayi: peptidoglycan recycling

This protein is involved in the pathway peptidoglycan recycling, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan recycling and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei58SubstrateUniRule annotation1
Binding sitei66SubstrateUniRule annotation1
Binding sitei129SubstrateUniRule annotation1
Sitei170Important for catalytic activityUniRule annotation1
Active sitei172Proton donor/acceptorUniRule annotation1
Active sitei244NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotationSAAS annotationImported, Hydrolase
Biological processCell cycle, Cell divisionUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00544.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidaseUniRule annotationSAAS annotation (EC:3.2.1.52UniRule annotationSAAS annotation)
Alternative name(s):
Beta-N-acetylhexosaminidaseUniRule annotation
N-acetyl-beta-glucosaminidaseUniRule annotation
Gene namesi
Name:nagZUniRule annotationImported
Ordered Locus Names:EAMY_1487Imported
OrganismiErwinia amylovora (strain CFBP1430)Imported
Taxonomic identifieri665029 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeErwinia
Proteomesi
  • UP000001841 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi665029.EAMY_1487.

Structurei

3D structure databases

ProteinModelPortaliD4I112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 309Glyco_hydro_3InterPro annotationAdd BLAST301

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni159 – 160Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107QPA. Bacteria.
COG1472. LUCA.
HOGENOMiHOG000248526.
KOiK01207.
OMAiHKETPRD.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
HAMAPiMF_00364. NagZ. 1 hit.
InterProiView protein in InterPro
IPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR036962. Glyco_hydro_3_N_sf.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00933. Glyco_hydro_3. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiView protein in PROSITE
PS00775. GLYCOSYL_HYDROL_F3. 1 hit.

Sequencei

Sequence statusi: Complete.

D4I112-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDVLGCELD AEEREILQHP LTGGLILFSR NYHDPVQLRE LVRQIRSASR
60 70 80 90 100
HRLLVAVDQE GGRVQRFRQG FSRLPAMQAF AALNPSPEAE KLAQQAGWLM
110 120 130 140 150
ASEMIAMDID ISFAPVLDIG HGSAAIGERS FHQDPAVALQ MARCFIRGMR
160 170 180 190 200
DAGMKTTGKH FPGHGAVSAD SHKETPRDTR SEAEIRQQDM PIFQQLIAEQ
210 220 230 240 250
ALDAIMPAHV IYTQVDPRPA SGSPHWLKSV LRQELGYDGV IFSDDLSMEG
260 270 280 290 300
AAIMGSYPER ARSALEAGCD MILVCNNRPG AVSVLDNLPA MASARAARLF
310 320 330
HRGKVTRQQL IDSPRWKETS AALARLQDRW LAHKADAGS
Length:339
Mass (Da):37,374
Last modified:May 18, 2010 - v1
Checksum:i3DB54FB9309C6469
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN434113 Genomic DNA. Translation: CBA20437.1.

Genome annotation databases

EnsemblBacteriaiCBA20437; CBA20437; EAMY_1487.
KEGGieam:EAMY_1487.
PATRICifig|665029.3.peg.1447.

Similar proteinsi

Entry informationi

Entry nameiD4I112_ERWAC
AccessioniPrimary (citable) accession number: D4I112
Entry historyiIntegrated into UniProtKB/TrEMBL: May 18, 2010
Last sequence update: May 18, 2010
Last modified: October 25, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported