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Protein

Dihydrofolate synthase/folylpolyglutamate synthase

Gene

folC

Organism
Erwinia amylovora (strain CFBP1430)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionLigaseUniRule annotationImported
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrofolate synthase/folylpolyglutamate synthaseUniRule annotation
Gene namesi
Name:folCImported
Ordered Locus Names:EAMY_2407Imported
OrganismiErwinia amylovora (strain CFBP1430)Imported
Taxonomic identifieri665029 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeErwinia
Proteomesi
  • UP000001841 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi665029.EAMY_2407

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 195Mur_ligase_MInterPro annotationAdd BLAST144
Domaini285 – 348Mur_ligase_CInterPro annotationAdd BLAST64

Sequence similaritiesi

Belongs to the folylpolyglutamate synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DPM Bacteria
COG0285 LUCA
HOGENOMiHOG000019982
KOiK11754
OMAiYFEMGTL

Family and domain databases

Gene3Di3.40.1190.10, 1 hit
3.90.190.20, 1 hit
InterProiView protein in InterPro
IPR001645 Folylpolyglutamate_synth
IPR018109 Folylpolyglutamate_synth_CS
IPR036565 Mur-like_cat_sf
IPR004101 Mur_ligase_C
IPR036615 Mur_ligase_C_dom_sf
IPR013221 Mur_ligase_cen
PANTHERiPTHR11136 PTHR11136, 1 hit
PfamiView protein in Pfam
PF02875 Mur_ligase_C, 1 hit
PF08245 Mur_ligase_M, 1 hit
PIRSFiPIRSF001563 Folylpolyglu_synth, 1 hit
SUPFAMiSSF53244 SSF53244, 1 hit
SSF53623 SSF53623, 1 hit
TIGRFAMsiTIGR01499 folC, 1 hit
PROSITEiView protein in PROSITE
PS01011 FOLYLPOLYGLU_SYNT_1, 1 hit
PS01012 FOLYLPOLYGLU_SYNT_2, 1 hit

Sequencei

Sequence statusi: Complete.

D4HXG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNLPQATSS LAAWLHYLEH LHSQAVDLGL ERVQRVATAL DLLTPAPVVI
60 70 80 90 100
TVAGTNGKGT TCRTLETLLL AAGYRVGVYS SPHLVRYTER VRVQGEELAE
110 120 130 140 150
TAHTASFAAI EAGRAATSLT YFEFGTLSAL WLFKQARLDV VILEVGLGGR
160 170 180 190 200
LDATNMVNAD VAVVTSIALD HTDWLGTDRE SIGREKAGIF RKGKPAVVGE
210 220 230 240 250
PDMPGSIAVI AAEKGAQLRQ RDRDWSYQLN GDSWSFHDAS GSIEHLPLPQ
260 270 280 290 300
VPLPNAATAL AALRASTLEV EEAIIRRSLH QAILPGRFQT VSESPRVILD
310 320 330 340 350
VAHNPHAASY LAGRLAEIKG EAKVHAVVGM LHDKDIAGTL ACLAPQVDYW
360 370 380 390 400
YCAPLEGPRG ASAEQLMTHL KAAQSFASVT AAWHHALMQA GQQDIVLVCG
410 420
SFHTVAHVME TMASENGSGK
Length:420
Mass (Da):45,045
Last modified:May 18, 2010 - v1
Checksum:i852DC88F7851ECD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN434113 Genomic DNA Translation: CBA21668.1
RefSeqiWP_004158681.1, NC_013961.1

Genome annotation databases

EnsemblBacteriaiCBA21668; CBA21668; EAMY_2407
GeneIDi8912684
KEGGieam:EAMY_2407
PATRICifig|665029.3.peg.2319

Similar proteinsi

Entry informationi

Entry nameiD4HXG7_ERWAC
AccessioniPrimary (citable) accession number: D4HXG7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 18, 2010
Last sequence update: May 18, 2010
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health