Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Bifunctional aspartokinase/homoserine dehydrogenase II

Gene

metL

Organism
Erwinia amylovora (strain CFBP1430)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. aspartate kinase activity Source: UniProtKB-EC
  2. homoserine dehydrogenase activity Source: InterPro
  3. NADP binding Source: InterPro

GO - Biological processi

  1. aspartate family amino acid biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Enzyme and pathway databases

BioCyciEAMY665029:GCM3-140-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Bifunctional aspartokinase/homoserine dehydrogenase IIImported (EC:2.7.2.4Imported)
Gene namesi
Name:metLImported
Ordered Locus Names:EAMY_0139Imported
OrganismiErwinia amylovora (strain CFBP1430)Imported
Taxonomic identifieri665029 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeErwinia
ProteomesiUP000001841: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD4HUF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000271594.
KOiK12525.
OMAiTLQYPEF.

Family and domain databases

Gene3Di3.40.1160.10. 2 hits.
3.40.50.720. 1 hit.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR005106. Asp/hSer_DH_NAD-bd.
IPR018042. Aspartate_kinase_CS.
IPR011147. Bifunc_aspartokin/hSer_DH.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
PF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000727. ThrA. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
PROSITEiPS00324. ASPARTOKINASE. 1 hit.
PS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4HUF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYSAVAKAG SSRQLHKFGG SSLADAKCYQ RVAGIMAEYS QPGDLMVVSA
60 70 80 90 100
AGSTTNQLIS WLKLSQSDRL SAHQVQQALR RYQSDLISSL LPPDVAATLI
110 120 130 140 150
AELISDLEKL AALLDGVMTD AIYAEVVGHG EIWSARLMSA VLTLRDIEAA
160 170 180 190 200
CLDARDFLRA ERAVQPQVDE VKSLPLLQQL MAQYPSQRMV VTGFICGNDA
210 220 230 240 250
GETVLLGRNG SDYSATQIGA LAGVTRVTIW SDVAGVYSAD PRKVKDACLL
260 270 280 290 300
PLLRLDEASE LARLAAPVLH SRTLQPVSGS DIDLQLRCSY QPEQGSTRIE
310 320 330 340 350
RVLASGTGAR IVTSHDDVCL IEFQVPAQHD FASLHKEIDQ LLQRAQVRPL
360 370 380 390 400
ATGIHPDRNL LQLCYTSEVV NSALTLLQDA ALPGRLQLRE SMALVAMVGA
410 420 430 440 450
GVCRNPLHSH RFWQQMKDQP VEFIWQSQDG ISLVAVLRVG PTEHLIRGLH
460 470 480 490 500
QTLFRAEKQI GLVLFGKGNI GSRWLELFAR EQETISARTG FEYILAGVVD
510 520 530 540 550
SRRSLLSYQG LDASRAMAFF EDEAVLQDEE SLFLWMRAHP FDDLVVLDVT
560 570 580 590 600
ASEILAGQYL DFASYGFHVI GANKVAGAST SDSYRQIRDA FAKTGGHWLY
610 620 630 640 650
NATVGAGLPV NHTVRDLRES GDSILSISGI FSGTLSWLFL QFDGTVPFTE
660 670 680 690 700
LVDQAWQQGL TEPDPRVDLS GQDVMRKLVI LAREAGYDIE PDQVRVESLV
710 720 730 740 750
PVDCQTGSVD HFFDNGDALN DQMLQRFEAA QEMGLVLRYV ARFDANGKAR
760 770 780 790 800
VGVEAVRADH PLAALLPCDN VFAIESRWYR DNPLVIRGPG AGRDVTAGAI
810
QSDLNRLAQL L
Length:811
Mass (Da):88,837
Last modified:May 18, 2010 - v1
Checksum:i8F2E04D2279AD9DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN434113 Genomic DNA. Translation: CBA19081.1.
RefSeqiYP_003529497.1. NC_013961.1.

Genome annotation databases

EnsemblBacteriaiCBA19081; CBA19081; EAMY_0139.
GeneIDi8913298.
KEGGieam:EAMY_0139.
PATRICi35404418. VBIErwAmy142366_0161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN434113 Genomic DNA. Translation: CBA19081.1.
RefSeqiYP_003529497.1. NC_013961.1.

3D structure databases

ProteinModelPortaliD4HUF8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBA19081; CBA19081; EAMY_0139.
GeneIDi8913298.
KEGGieam:EAMY_0139.
PATRICi35404418. VBIErwAmy142366_0161.

Phylogenomic databases

HOGENOMiHOG000271594.
KOiK12525.
OMAiTLQYPEF.

Enzyme and pathway databases

BioCyciEAMY665029:GCM3-140-MONOMER.

Family and domain databases

Gene3Di3.40.1160.10. 2 hits.
3.40.50.720. 1 hit.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR005106. Asp/hSer_DH_NAD-bd.
IPR018042. Aspartate_kinase_CS.
IPR011147. Bifunc_aspartokin/hSer_DH.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
PF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000727. ThrA. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
PROSITEiPS00324. ASPARTOKINASE. 1 hit.
PS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the fire blight pathogen Erwinia amylovora CFBP 1430 and comparison to other Erwinia spp."
    Smits T.H., Rezzonico F., Kamber T., Blom J., Goesmann A., Frey J.E., Duffy B.
    Mol. Plant Microbe Interact. 23:384-393(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFBP1430Imported.

Entry informationi

Entry nameiD4HUF8_ERWAC
AccessioniPrimary (citable) accession number: D4HUF8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 18, 2010
Last sequence update: May 18, 2010
Last modified: January 7, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.