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D4HEE4 (D4HEE4_PROAS) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:HMPREF0675_4405 EMBL ADD99967.1
OrganismPropionibacterium acnes (strain SK137) [Complete proteome] [HAMAP] EMBL ADD99967.1
Taxonomic identifier553199 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain144 – 355212ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding176 – 23156ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3091Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3221Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3221Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3241Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D4HEE4 [UniParc].

Last modified May 18, 2010. Version 1.
Checksum: D2518A3EFC9190FD

FASTA36539,261
        10         20         30         40         50         60 
MNRIHVAVIF GGMSSEHSIS CLSAANVVAA IDAERFDVSG VGISPEGIWV RYGADEILAL 

        70         80         90        100        110        120 
PGTGQLPTVE VGDRPLVSVK QMPEGTCIVD TEGNVDAVQV VFPVLHGPFG EDGTIQGLLE 

       130        140        150        160        170        180 
MAGVRYVGCG VAASANCMDK HLTKMILSEA GVLVGPYVVV RDHEWREDRN AVLKAVSRLE 

       190        200        210        220        230        240 
YPVFVKPARG GSSIGISRVT SPEHLETAIE MAREHDSKVL IEQGIRGREI ECSVIDGRHG 

       250        260        270        280        290        300 
AAPRASVPGE IVVHDPDGFY DFEAKYLSGE QKASVQAHAN LDDATRRRVQ KVAIKAFQVL 

       310        320        330        340        350        360 
GCEGLARIDT FVTPDGAVYV NEPNTMPGFT RSSGFPLMWQ ASGMTYAQIV SELIELALER 


PLGLR 

« Hide

References

[1]"The complete genome of Propionibacterium acnes SK137."
Harkins D.M., Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G., Nelson K.E.
Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SK137.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001977 Genomic DNA. Translation: ADD99967.1.
RefSeqYP_003581558.1. NC_014039.1.

3D structure databases

ProteinModelPortalD4HEE4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADD99967; ADD99967; HMPREF0675_4405.
GeneID9075014.
KEGGpak:HMPREF0675_4405.
PATRIC37227447. VBIProAcn10541_1391.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011593.
KOK01921.
OMAQIDVIFP.

Enzyme and pathway databases

BioCycPACN553199:GHRZ-1394-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD4HEE4_PROAS
AccessionPrimary (citable) accession number: D4HEE4
Entry history
Integrated into UniProtKB/TrEMBL: May 18, 2010
Last sequence update: May 18, 2010
Last modified: June 11, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)