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D4HDK9

- D4HDK9_PROAS

UniProt

D4HDK9 - D4HDK9_PROAS

Protein

Thymidine kinase

Gene

tdk

Organism
Propionibacterium acnes (strain SK137)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (18 May 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei87 – 871Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 168ATPUniRule annotation
    Nucleotide bindingi86 – 894ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPACN553199:GHRZ-1099-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    Ordered Locus Names:HMPREF0675_4109Imported
    OrganismiPropionibacterium acnes (strain SK137)Imported
    Taxonomic identifieri553199 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
    ProteomesiUP000008987: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD4HDK9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000076391.
    KOiK00857.
    OMAiELKTVCH.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D4HDK9-1 [UniParc]FASTAAdd to Basket

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    MAELVFHTGP MDSGKSTLAL QMDHAQSAHD RQGVRYAMHD RSGGARITSR    50
    IGLSVEAVEV TDSLDLYQDI VSRLSRGGRI DYLICDEAQF YRTKQIDQLA 100
    RVVDDLDIDV YCFGILADFR TELFPGSKRL VELADRVVEP PVSPLCWCGR 150
    PATHNARIVD GKLVREGDQV GVGDIGGGSE IHYEVLCRRH HRQGITGEIS 200
    RATLSEQTLP FDGSRS 216
    Length:216
    Mass (Da):23,926
    Last modified:May 18, 2010 - v1
    Checksum:iF6055E1F110118C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001977 Genomic DNA. Translation: ADE00600.1.
    RefSeqiYP_003581273.1. NC_014039.1.

    Genome annotation databases

    EnsemblBacteriaiADE00600; ADE00600; HMPREF0675_4109.
    GeneIDi9073640.
    KEGGipak:HMPREF0675_4109.
    PATRICi37226840. VBIProAcn10541_1096.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001977 Genomic DNA. Translation: ADE00600.1 .
    RefSeqi YP_003581273.1. NC_014039.1.

    3D structure databases

    ProteinModelPortali D4HDK9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADE00600 ; ADE00600 ; HMPREF0675_4109 .
    GeneIDi 9073640.
    KEGGi pak:HMPREF0675_4109.
    PATRICi 37226840. VBIProAcn10541_1096.

    Phylogenomic databases

    HOGENOMi HOG000076391.
    KOi K00857.
    OMAi ELKTVCH.

    Enzyme and pathway databases

    BioCyci PACN553199:GHRZ-1099-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome of Propionibacterium acnes SK137."
      Harkins D.M., Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G., Nelson K.E.
      Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SK137Imported.

    Entry informationi

    Entry nameiD4HDK9_PROAS
    AccessioniPrimary (citable) accession number: D4HDK9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 18, 2010
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3