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Protein

Vitamin B12-dependent ribonucleotide reductase

Gene

HMPREF0675_4085

Organism
Propionibacterium acnes (strain SK137)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.UniRule annotation

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

Cofactori

adenosylcob(III)alaminUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processDNA synthesisUniRule annotation
LigandCobalaminUniRule annotation, Cobalt, Nucleotide-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin B12-dependent ribonucleotide reductaseUniRule annotation (EC:1.17.4.1UniRule annotation)
Gene namesi
Ordered Locus Names:HMPREF0675_4085Imported
OrganismiPropionibacterium acnes (strain SK137)Imported
Taxonomic identifieri553199 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesPropionibacteriaceaeCutibacterium
Proteomesi
  • UP000008987 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 131Ribonuc_red_2_NInterPro annotationAdd BLAST84
Domaini152 – 688RIBORED_LARGEInterPro annotationAdd BLAST537

Sequence similaritiesi

Belongs to the ribonucleoside diphosphate reductase class-2 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021771.
KOiK00525.
OMAiPQQVSAC.

Family and domain databases

InterProiView protein in InterPro
IPR013678. RNR_2_N.
IPR000788. RNR_lg_C.
IPR013344. RNR_NrdJ/NrdZ.
PfamiView protein in Pfam
PF08471. Ribonuc_red_2_N. 1 hit.
PF02867. Ribonuc_red_lgC. 1 hit.
PRINTSiPR01183. RIBORDTASEM1.
TIGRFAMsiTIGR02504. NrdJ_Z. 1 hit.

Sequencei

Sequence statusi: Complete.

D4HDI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTETKSAPRR TSRSKGLHVE RIFSTEGVHP YDEVTWERRD VVQTNWRTGD
60 70 80 90 100
VVFEQRGVEF PDFWSVNAST IVTNKYFRGA LGTPAREDSL KTLIDRVVNT
110 120 130 140 150
YVTTGRKNGY FASDDDAKVF GEELTWLLVH QYFSFNSPVW FNVGTTSPQQ
160 170 180 190 200
VSACFILSVD DSMESILNWY REEGFIFKGG SGAGLNISRI RSSKELLSSG
210 220 230 240 250
GTASGPVSFM RGADASAGTI KSGGATRRAA KMVVLDIDHP DIEEFIETKA
260 270 280 290 300
REEDKIRALR DAGFDMDLGG RDIVSVQYQN ANNSVRVSDA FMAAVEHGKP
310 320 330 340 350
FGLMSRTEPD KVLDTVDAKE LFGKIAQAAW ECADPGLQYD DTINAWHTTP
360 370 380 390 400
NSGRINASNP CSEYMSLDNS SCNLASLNLL KFLDENDHFD VEKFTRAVEL
410 420 430 440 450
VITAMDISIC FADFPTEAIS KTTRNFRQLG IGYANLGALL MALGLGYDSD
460 470 480 490 500
GGRALAAAIT SLMTGVSYRR SAELAAIVGP YGGYSENAEP HQAVMARHRD
510 520 530 540 550
ANRQVHPLHN NDTAVLTAAK AEWDKVVKLG HTNGFRNAQA SVLAPTGTIG
560 570 580 590 600
FMMDCDTTGI EPDFSLVKFK KMVGGGSMQI VNQTVPRALK NLGYTPEQAE
610 620 630 640 650
KIVAYIADNG SVVGAPDLDE AHYEVFDCAM GTRFIAPMGH VRMMAAVQPF
660 670 680 690 700
LSGAISKTVN LPESSTVEDI AGVYMEGWKL GLKALAVYRD NCKVGQPLSE
710 720 730 740 750
AKKKEEEEKA EPEVRIEYRP RRQRLPKSRM GRTTSFQVAG AGGYLTTGAY
760 770 780 790 800
DSGRLGEIFL KLGKQGSTLA GVMDAFSIAV SIGLQYGVPL ESFVQKFSNL
810 820 830 840 850
KFEPAGMTDD PDIRISSSII DYVFRRLALD YLDFDERAEL GIYTAAERAR
860 870 880 890 900
YVQTGSYLSD EEDELIDSET LKDTPADRVR VHEDGANQPG LFATQEAVEQ
910 920 930 940 950
IGEAHTSAEL LEEQIGREVD APLCLTCGTK MRPSGSCYVC EGCGSTSGCS
Length:950
Mass (Da):103,939
Last modified:May 18, 2010 - v1
Checksum:iAA082CBA04B6BA8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001977 Genomic DNA. Translation: ADD99672.1.
RefSeqiWP_002515591.1. NC_014039.1.

Genome annotation databases

EnsemblBacteriaiADD99672; ADD99672; HMPREF0675_4085.
KEGGipak:HMPREF0675_4085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001977 Genomic DNA. Translation: ADD99672.1.
RefSeqiWP_002515591.1. NC_014039.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADD99672; ADD99672; HMPREF0675_4085.
KEGGipak:HMPREF0675_4085.

Phylogenomic databases

HOGENOMiHOG000021771.
KOiK00525.
OMAiPQQVSAC.

Family and domain databases

InterProiView protein in InterPro
IPR013678. RNR_2_N.
IPR000788. RNR_lg_C.
IPR013344. RNR_NrdJ/NrdZ.
PfamiView protein in Pfam
PF08471. Ribonuc_red_2_N. 1 hit.
PF02867. Ribonuc_red_lgC. 1 hit.
PRINTSiPR01183. RIBORDTASEM1.
TIGRFAMsiTIGR02504. NrdJ_Z. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiD4HDI5_PROAS
AccessioniPrimary (citable) accession number: D4HDI5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 18, 2010
Last sequence update: May 18, 2010
Last modified: June 7, 2017
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.