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D4GV77

- D4GV77_HALVD

UniProt

D4GV77 - D4GV77_HALVD

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Protein

Ribulose bisphosphate carboxylase

Gene

rbcL

Organism
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei150 – 1501Proton acceptorUniRule annotation
Binding sitei152 – 1521SubstrateUniRule annotation
Metal bindingi176 – 1761Magnesium; via carbamate groupUniRule annotation
Metal bindingi178 – 1781MagnesiumUniRule annotation
Metal bindingi179 – 1791MagnesiumUniRule annotation
Active sitei268 – 2681Proton acceptorUniRule annotation
Binding sitei269 – 2691SubstrateUniRule annotation
Binding sitei301 – 3011SubstrateUniRule annotation
Sitei309 – 3091Transition state stabilizerUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. oxidoreductase activity Source: UniProtKB-KW
  3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. carbon fixation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciHVOL309800:GCOK-974-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotationImported
Ordered Locus Names:HVO_0970Imported
ORF Names:C498_13921Imported
OrganismiHaloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)Imported
Taxonomic identifieri309800 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloferax
ProteomesiUP000008243: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei176 – 1761N6-carboxylysineUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD4GV77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni337 – 3393Substrate bindingUniRule annotation
Regioni359 – 3624Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the RuBisCO large chain family.UniRule annotation
Belongs to the RuBisCO large chain family. Type III subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230831.
KOiK01601.
OMAiFTQDWAS.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProiIPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

Sequencei

Sequence statusi: Complete.

D4GV77 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGITYEDFLD LDYEPTDEDL VCTFRIDPAT GMSTEAAASR VASESSNGTW
60 70 80 90 100
AALQTGADFT DMGATTFDID GDLIRVAYPA GLFEPGNMPQ VLSCIAGNIM
110 120 130 140 150
GMKAVDTIRL LDCEWPESVV SAYPGPLYGS SVREEIFGVT DRPITATVPK
160 170 180 190 200
PKVGLSTAAH AQVGYDAWVG GVDLLKDDEN LTDQAFNPFS DRLTESLSLR
210 220 230 240 250
DDAEDETGEK KSYLINVTAD TQTMLDRVDE VAAQGGEYVM VDIITAGWAG
260 270 280 290 300
LQTVRERTEK HGLAIHAHRA MHAAFDRLPA HGVSMRVLAQ VSRLCGVDQL
310 320 330 340 350
HTGTAGLGKL ANEDTVGINE WLAGDLHGAT DVLPVASGGL HPGLLPDLLD
360 370 380 390 400
ATGTNVCVQL GGGIHGHPDG TRAGAVALRS AIDAYVEGRA ITEAAEETPE
410
LAVALDKWGT ETPR
Length:414
Mass (Da):43,922
Last modified:May 18, 2010 - v1
Checksum:i436AC5738813777B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001956 Genomic DNA. Translation: ADE04153.1.
AOHU01000093 Genomic DNA. Translation: ELY27227.1.
RefSeqiWP_004043974.1. NZ_AOHU01000093.1.
YP_003535027.1. NC_013967.1.

Genome annotation databases

EnsemblBacteriaiADE04153; ADE04153; HVO_0970.
ELY27227; ELY27227; C498_13921.
GeneIDi8926563.
KEGGihvo:HVO_0970.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001956 Genomic DNA. Translation: ADE04153.1 .
AOHU01000093 Genomic DNA. Translation: ELY27227.1 .
RefSeqi WP_004043974.1. NZ_AOHU01000093.1.
YP_003535027.1. NC_013967.1.

3D structure databases

ProteinModelPortali D4GV77.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADE04153 ; ADE04153 ; HVO_0970 .
ELY27227 ; ELY27227 ; C498_13921 .
GeneIDi 8926563.
KEGGi hvo:HVO_0970.

Phylogenomic databases

HOGENOMi HOG000230831.
KOi K01601.
OMAi FTQDWAS.

Enzyme and pathway databases

BioCyci HVOL309800:GCOK-974-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProi IPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2Imported.
  2. "The Complete Genome Sequence of Haloferax volcanii DS2, a Model Archaeon."
    Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R., Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J., Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.
    PLoS ONE 5:E9605-E9605(2010)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DS2Imported.
  3. Becker E.A., Seitzer P., Tritt A., Larsen D., Yao A., Wu D., Darling A., Eisen J.A., Facciotti M.T.
    Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DS2Imported.

Entry informationi

Entry nameiD4GV77_HALVD
AccessioniPrimary (citable) accession number: D4GV77
Entry historyi
Integrated into UniProtKB/TrEMBL: May 18, 2010
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3