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D4GV77

- D4GV77_HALVD

UniProt

D4GV77 - D4GV77_HALVD

Protein

Ribulose bisphosphate carboxylase

Gene

rbcL

Organism
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (18 May 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.UniRule annotation

    Catalytic activityi

    2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
    3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei150 – 1501Proton acceptorUniRule annotation
    Binding sitei152 – 1521SubstrateUniRule annotation
    Metal bindingi176 – 1761Magnesium; via carbamate groupUniRule annotation
    Metal bindingi178 – 1781MagnesiumUniRule annotation
    Metal bindingi179 – 1791MagnesiumUniRule annotation
    Active sitei268 – 2681Proton acceptorUniRule annotation
    Binding sitei269 – 2691SubstrateUniRule annotation
    Binding sitei301 – 3011SubstrateUniRule annotation
    Sitei309 – 3091Transition state stabilizerUniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. AMP catabolic process Source: UniProtKB-HAMAP
    2. carbon fixation Source: InterPro

    Keywords - Molecular functioni

    LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Carbon dioxide fixationUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciHVOL309800:GCOK-974-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
    Short name:
    RuBisCOUniRule annotation
    Gene namesi
    Name:rbcLUniRule annotationImported
    Ordered Locus Names:HVO_0970Imported
    ORF Names:C498_13921Imported
    OrganismiHaloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)Imported
    Taxonomic identifieri309800 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloferax
    ProteomesiUP000008243: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei176 – 1761N6-carboxylysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.UniRule annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni337 – 3393Substrate bindingUniRule annotation
    Regioni359 – 3624Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the RuBisCO large chain family.UniRule annotation
    Belongs to the RuBisCO large chain family. Type III subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000230831.
    KOiK01601.
    OMAiFTQDWAS.

    Family and domain databases

    Gene3Di3.20.20.110. 1 hit.
    3.30.70.150. 1 hit.
    InterProiIPR017712. RuBisCO_III.
    IPR000685. RuBisCO_lsu_C.
    IPR017443. RuBisCO_lsu_fd_N.
    IPR017444. RuBisCO_lsu_N.
    [Graphical view]
    PfamiPF00016. RuBisCO_large. 1 hit.
    PF02788. RuBisCO_large_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF51649. SSF51649. 1 hit.
    SSF54966. SSF54966. 1 hit.
    TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D4GV77-1 [UniParc]FASTAAdd to Basket

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    MGITYEDFLD LDYEPTDEDL VCTFRIDPAT GMSTEAAASR VASESSNGTW    50
    AALQTGADFT DMGATTFDID GDLIRVAYPA GLFEPGNMPQ VLSCIAGNIM 100
    GMKAVDTIRL LDCEWPESVV SAYPGPLYGS SVREEIFGVT DRPITATVPK 150
    PKVGLSTAAH AQVGYDAWVG GVDLLKDDEN LTDQAFNPFS DRLTESLSLR 200
    DDAEDETGEK KSYLINVTAD TQTMLDRVDE VAAQGGEYVM VDIITAGWAG 250
    LQTVRERTEK HGLAIHAHRA MHAAFDRLPA HGVSMRVLAQ VSRLCGVDQL 300
    HTGTAGLGKL ANEDTVGINE WLAGDLHGAT DVLPVASGGL HPGLLPDLLD 350
    ATGTNVCVQL GGGIHGHPDG TRAGAVALRS AIDAYVEGRA ITEAAEETPE 400
    LAVALDKWGT ETPR 414
    Length:414
    Mass (Da):43,922
    Last modified:May 18, 2010 - v1
    Checksum:i436AC5738813777B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001956 Genomic DNA. Translation: ADE04153.1.
    AOHU01000093 Genomic DNA. Translation: ELY27227.1.
    RefSeqiYP_003535027.1. NC_013967.1.

    Genome annotation databases

    EnsemblBacteriaiADE04153; ADE04153; HVO_0970.
    ELY27227; ELY27227; C498_13921.
    GeneIDi8926563.
    KEGGihvo:HVO_0970.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001956 Genomic DNA. Translation: ADE04153.1 .
    AOHU01000093 Genomic DNA. Translation: ELY27227.1 .
    RefSeqi YP_003535027.1. NC_013967.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADE04153 ; ADE04153 ; HVO_0970 .
    ELY27227 ; ELY27227 ; C498_13921 .
    GeneIDi 8926563.
    KEGGi hvo:HVO_0970.

    Phylogenomic databases

    HOGENOMi HOG000230831.
    KOi K01601.
    OMAi FTQDWAS.

    Enzyme and pathway databases

    BioCyci HVOL309800:GCOK-974-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.110. 1 hit.
    3.30.70.150. 1 hit.
    InterProi IPR017712. RuBisCO_III.
    IPR000685. RuBisCO_lsu_C.
    IPR017443. RuBisCO_lsu_fd_N.
    IPR017444. RuBisCO_lsu_N.
    [Graphical view ]
    Pfami PF00016. RuBisCO_large. 1 hit.
    PF02788. RuBisCO_large_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51649. SSF51649. 1 hit.
    SSF54966. SSF54966. 1 hit.
    TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2Imported.
    2. "The Complete Genome Sequence of Haloferax volcanii DS2, a Model Archaeon."
      Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R., Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J., Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.
      PLoS ONE 5:E9605-E9605(2010)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DS2Imported.
    3. Becker E.A., Seitzer P., Tritt A., Larsen D., Yao A., Wu D., Darling A., Eisen J.A., Facciotti M.T.
      Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DS2Imported.

    Entry informationi

    Entry nameiD4GV77_HALVD
    AccessioniPrimary (citable) accession number: D4GV77
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 18, 2010
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3