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D4GTS2 (D4GTS2_HALVD) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800

Catalytic activity

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800

L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800

Cofactor

Pyridoxal phosphate By similarity. PIRNR PIRNR038800

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800

Subunit structure

Homodimer By similarity. PIRNR PIRNR038800

Sequence similarities

Belongs to the kynureninase family. PIRNR PIRNR038800

Sequences

Sequence LengthMass (Da)Tools
D4GTS2 [UniParc].

Last modified May 18, 2010. Version 1.
Checksum: 1305C143C28E3506

FASTA42546,051
        10         20         30         40         50         60 
MTDSGNPAVD AAREMDAADP LSDLRDRFFV PEGELYMDGN SLGPLSVDAE AALDRVVDEW 

        70         80         90        100        110        120 
RDLAIRGWTD ADPEWFSYGE RLGDRLAPLV GAKPEEVVVA NSTTVNIHAL VGTFYDPARG 

       130        140        150        160        170        180 
EKIVVDDLDF PTDHYAIRAQ LRAAGRDPDE ALRVVESRDG RTIETEDVLD AVDDDVGMVF 

       190        200        210        220        230        240 
LPSVLYRSGQ LFDIETLTEA AHEAGALAGF DLAHSVGAVP HSLSEVGVDF AVWCHYKYLN 

       250        260        270        280        290        300 
AGPGSIAGLY VNERHFGVTP ALAGWWGNDK ETQFDMAMTY EPAQSAGAFQ SGTVPVLSAA 

       310        320        330        340        350        360 
PLDGALDIVE DAGGVTALRE KSLALTDYLI ALVDERLPEC EVGTPRDPAA RGGHVAVEHP 

       370        380        390        400        410        420 
EAYRVSLALK ERGVIVDFRQ PNVVRMAPAP AYVGFEDVYR AVEHFREILD GEAYEAFEKQ 


SGGVT 

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References

« Hide 'large scale' references
[1]"The Complete Genome Sequence of Haloferax volcanii DS2, a Model Archaeon."
Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R., Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J., Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.
PLoS ONE 5:E9605-E9605(2010)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: DS2 EMBL ADE02278.1.
[2]"The complete genome sequence of Haloferax volcanii DS2, a model archaeon."
Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R., Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J., Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.
PLoS ONE 5:E9605-E9605(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2.
[3]Becker E.A., Seitzer P., Tritt A., Larsen D., Yao A., Wu D., Darling A., Eisen J.A., Facciotti M.T.
Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: DS2 EMBL ELY32650.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001956 Genomic DNA. Translation: ADE02278.1.
AOHU01000045 Genomic DNA. Translation: ELY32650.1.
RefSeqYP_003536521.1. NC_013967.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADE02278; ADE02278; HVO_2503.
ELY32650; ELY32650; C498_07803.
GeneID8926216.
KEGGhvo:HVO_2503.

Phylogenomic databases

HOGENOMHOG000242438.
KOK01556.
OMAVWDLAHS.

Enzyme and pathway databases

BioCycHVOL309800:GCOK-2506-MONOMER.
UniPathwayUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPMF_01970. Kynureninase.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR14084. PTHR14084. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF038800. KYNU. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR01814. kynureninase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD4GTS2_HALVD
AccessionPrimary (citable) accession number: D4GTS2
Entry history
Integrated into UniProtKB/TrEMBL: May 18, 2010
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)