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D4GQU6

- GLPA2_HALVD

UniProt

D4GQU6 - GLPA2_HALVD

Protein

Anaerobic glycerol-3-phosphate dehydrogenase subunit A2

Gene

gpdA2

Organism
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (18 May 2010)
      Previous versions | rss
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    Functioni

    Conversion of glycerol 3-phosphate to dihydroxyacetone phosphate. Functional analog of glpA1 required for the basal levels of glycerol-3-phosphate dehydrogenase activity, but not expressed during standard growth on glycerol or when glpA1 is knockout.1 Publication

    Catalytic activityi

    sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.1 Publication

    Cofactori

    FAD.By similarity
    FMN.By similarity

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi4 – 3229FADSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. FMN binding Source: InterPro
    3. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycerol-3-phosphate metabolic process Source: InterPro
    2. glycerol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciHVOL309800:GCOK-3291-MONOMER.
    UniPathwayiUPA00618; UER00673.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anaerobic glycerol-3-phosphate dehydrogenase subunit A2 (EC:1.1.5.3)
    Short name:
    G-3-P dehydrogenase A2
    Short name:
    G3PDH A2
    Gene namesi
    Name:gpdA2
    Ordered Locus Names:HVO_A0269
    Encoded oniPlasmid pHV40 Publication
    OrganismiHaloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
    Taxonomic identifieri309800 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloferax
    ProteomesiUP000008243: Plasmid pHV4

    Subcellular locationi

    Cell membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 563563Anaerobic glycerol-3-phosphate dehydrogenase subunit A2PRO_0000428860Add
    BLAST

    Interactioni

    Subunit structurei

    Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliD4GQU6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000004814.
    KOiK00111.
    OMAiWRELEWS.

    Family and domain databases

    InterProiIPR007419. BFD-like_2Fe2S-bd_dom.
    IPR006076. FAD-dep_OxRdtase.
    IPR000447. G3P_DH_FAD-dep.
    IPR017752. G3P_DH_GlpA_su.
    [Graphical view]
    PfamiPF01266. DAO. 1 hit.
    PF04324. Fer2_BFD. 1 hit.
    [Graphical view]
    PRINTSiPR01001. FADG3PDH.
    TIGRFAMsiTIGR03377. glycerol3P_GlpA. 1 hit.
    PROSITEiPS00977. FAD_G3PDH_1. 1 hit.
    PS00978. FAD_G3PDH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D4GQU6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYSVVVIGG GATGTGTARD LAMRGFDVTL VERGNLTEGT TGRTHGHLHS    50
    GARYAVSDKE SAVDCMRENR VLHRIAGHCI EDTGGLFVQL EGDSDDYFER 100
    KLAGCAECDI PTEVISGEEA RRREPYLTDA VERAIWVPDG AVDPFRLCVA 150
    NAASAVEHGA RIETHAEVVD LVVEGGRVAG VEVKRQGPNH HSEGAAGDTE 200
    TFEADYVVSA TGAWAGQLAA MAGVDLEMAI SKGAMVVTNV RQLDTVINRC 250
    LPKGEGDTII PHETTVLLGA NDDPVDDPDD YPEEQWEVDM MIDIASEMVP 300
    VVADARMIRA YWGVRPLYDP NPKSTTDPGD VTRNYFVLDH AERDGVAGFA 350
    SVVGGKLTTY REMAESVSDH VCEVLGVEEP CRTDEVPLPG SADPSALDEY 400
    MDEFDLRSPI ARRSGQRLGD RAPEVLDIDE PNPTLCECEA VTRAEVRDAI 450
    DQVGADLNGV RLRTRASMGN CQGGFCSHRL GAELYPDHGA EVARDAVDEL 500
    YQERWKGQRH ALWGEQLSQA MLNAMLHATT MNHDANHVAG DENIEYRAFD 550
    GGRTAVPEGS HGD 563
    Length:563
    Mass (Da):60,955
    Last modified:May 18, 2010 - v1
    Checksum:i50F390554781ED4C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001955 Genomic DNA. Translation: ADE02027.1.
    RefSeqiWP_013035148.1. NC_013966.1.
    YP_003533725.1. NC_013966.1.

    Genome annotation databases

    EnsemblBacteriaiADE02027; ADE02027; HVO_A0269.
    GeneIDi8923720.
    KEGGihvo:HVO_A0269.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001955 Genomic DNA. Translation: ADE02027.1 .
    RefSeqi WP_013035148.1. NC_013966.1.
    YP_003533725.1. NC_013966.1.

    3D structure databases

    ProteinModelPortali D4GQU6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADE02027 ; ADE02027 ; HVO_A0269 .
    GeneIDi 8923720.
    KEGGi hvo:HVO_A0269.

    Phylogenomic databases

    HOGENOMi HOG000004814.
    KOi K00111.
    OMAi WRELEWS.

    Enzyme and pathway databases

    UniPathwayi UPA00618 ; UER00673 .
    BioCyci HVOL309800:GCOK-3291-MONOMER.

    Family and domain databases

    InterProi IPR007419. BFD-like_2Fe2S-bd_dom.
    IPR006076. FAD-dep_OxRdtase.
    IPR000447. G3P_DH_FAD-dep.
    IPR017752. G3P_DH_GlpA_su.
    [Graphical view ]
    Pfami PF01266. DAO. 1 hit.
    PF04324. Fer2_BFD. 1 hit.
    [Graphical view ]
    PRINTSi PR01001. FADG3PDH.
    TIGRFAMsi TIGR03377. glycerol3P_GlpA. 1 hit.
    PROSITEi PS00977. FAD_G3PDH_1. 1 hit.
    PS00978. FAD_G3PDH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2.
    2. "Activity and transcriptional regulation of bacterial protein-like glycerol-3-phosphate dehydrogenase of the haloarchaea in Haloferax volcanii."
      Rawls K.S., Martin J.H., Maupin-Furlow J.A.
      J. Bacteriol. 193:4469-4476(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, DISRUPTION PHENOTYPE.
      Strain: DS2 / DS70.

    Entry informationi

    Entry nameiGLPA2_HALVD
    AccessioniPrimary (citable) accession number: D4GQU6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 14, 2014
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    H.volcanii contains 2 glpABC operons, one located on the main chromosome and the other on megaplasmid pHV4.1 Publication

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3