Skip Header

Contribute Send feedback
Read comments (?) or add your own

D4GBA0 (D4GBA0_TREPC) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase HAMAP-Rule MF_01201 RuleBase RU000608
EC=5.1.1.1 HAMAP-Rule MF_01201 RuleBase RU000608
Gene names
Name:alr EMBL ADD72782.1
Ordered Locus Names:TPChic_0681
OrganismTreponema pallidum subsp. pallidum (strain Chicago) [Complete proteome] [HAMAP]
Taxonomic identifier666714 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema ›

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201 RuleBase RU000608 SAAS SAAS020622

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201 RuleBase RU000608 SAAS SAAS020622

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201 SAAS SAAS020622 RuleBase RU004247

Sequence similarities

Belongs to the alanine racemase family. HAMAP-Rule MF_01201 RuleBase RU004188

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site331Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2671Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1341Substrate By similarity HAMAP-Rule MF_01201
Binding site3151Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue331N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
D4GBA0 [UniParc].

Last modified May 18, 2010. Version 1.
Checksum: 96387BFF1EAD0913

FASTA37740,312
        10         20         30         40         50         60 
MACNQALIHL ANLRHNLGEI MSRTRARVCL PVKADAYGHG ACDVAQAALS CGVHSFAVAC 

        70         80         90        100        110        120 
VQEASQLRAA GVRAPILCLS TPTAEEISSL IEHRVHTVIS ERAHIALIAR ALRQSADTGA 

       130        140        150        160        170        180 
TCGVHVKIDT GMGRIGCAPD EACALVQMVC ATPGLHLEGV CTHFSVADSV RAEDLQYTEM 

       190        200        210        220        230        240 
QRAHFMHCVQ YIRKSGISIP LVHAANSAAL LCHPRAHFDM VRPGLLAYGY APESVHPAVR 

       250        260        270        280        290        300 
SVFLPVMELV TQVRAIKKIP AGAYVSYQRL WRAHTETHVG ILPIGYADGV MRALSPGLQV 

       310        320        330        340        350        360 
CIGGKWYPVV GAICMDQCVV DLGTPLRVTV GDRVTLFGPQ DAGGPGQGAD VLASHAGTIP 

       370 
YELLCAIGKR VERVYIR

« Hide

References

[1]"Complete genome sequence and annotation of the Treponema pallidum subsp. pallidum Chicago strain."
Giacani L., Jeffrey B.M., Molini B.J., Le H.T., Lukehart S.A., Centurion-Lara A., Rockey D.D.
J. Bacteriol. 192:2645-2646(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Chicago EMBL ADD72782.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001752 Genomic DNA. Translation: ADD72782.1.
RefSeqYP_005631540.1. NC_017268.1.

3D structure databases

ProteinModelPortalD4GBA0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADD72782; ADD72782; TPChic_0681.
GeneID12270436.
KEGGtph:TPChic_0681.
PATRIC36800066. VBITrePal139508_0708.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000031444.
KOK01775.
OMAHQLETAV.

Enzyme and pathway databases

BioCycTPAL666714:GLMK-739-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD4GBA0_TREPC
AccessionPrimary (citable) accession number: D4GBA0
Entry history
Integrated into UniProtKB/TrEMBL: May 18, 2010
Last sequence update: May 18, 2010
Last modified: May 29, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info