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D4GBA0

- D4GBA0_TREPC

UniProt

D4GBA0 - D4GBA0_TREPC

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Protein

Alanine racemase

Gene
alr, TPChic_0681
Organism
Treponema pallidum subsp. pallidum (strain Chicago)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei33 – 331Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei134 – 1341Substrate By similarityUniRule annotation
Active sitei267 – 2671Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei315 – 3151Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciTPAL666714:GLMK-739-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:TPChic_0681Imported
OrganismiTreponema pallidum subsp. pallidum (strain Chicago)Imported
Taxonomic identifieri666714 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000001701: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD4GBA0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiIYSHLAL.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4GBA0-1 [UniParc]FASTAAdd to Basket

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MACNQALIHL ANLRHNLGEI MSRTRARVCL PVKADAYGHG ACDVAQAALS    50
CGVHSFAVAC VQEASQLRAA GVRAPILCLS TPTAEEISSL IEHRVHTVIS 100
ERAHIALIAR ALRQSADTGA TCGVHVKIDT GMGRIGCAPD EACALVQMVC 150
ATPGLHLEGV CTHFSVADSV RAEDLQYTEM QRAHFMHCVQ YIRKSGISIP 200
LVHAANSAAL LCHPRAHFDM VRPGLLAYGY APESVHPAVR SVFLPVMELV 250
TQVRAIKKIP AGAYVSYQRL WRAHTETHVG ILPIGYADGV MRALSPGLQV 300
CIGGKWYPVV GAICMDQCVV DLGTPLRVTV GDRVTLFGPQ DAGGPGQGAD 350
VLASHAGTIP YELLCAIGKR VERVYIR 377
Length:377
Mass (Da):40,312
Last modified:May 18, 2010 - v1
Checksum:i96387BFF1EAD0913
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001752 Genomic DNA. Translation: ADD72782.1.
RefSeqiYP_005631540.1. NC_017268.1.

Genome annotation databases

EnsemblBacteriaiADD72782; ADD72782; TPChic_0681.
GeneIDi12270436.
KEGGitph:TPChic_0681.
PATRICi36800066. VBITrePal139508_0708.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001752 Genomic DNA. Translation: ADD72782.1 .
RefSeqi YP_005631540.1. NC_017268.1.

3D structure databases

ProteinModelPortali D4GBA0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADD72782 ; ADD72782 ; TPChic_0681 .
GeneIDi 12270436.
KEGGi tph:TPChic_0681.
PATRICi 36800066. VBITrePal139508_0708.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.
OMAi IYSHLAL.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci TPAL666714:GLMK-739-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence and annotation of the Treponema pallidum subsp. pallidum Chicago strain."
    Giacani L., Jeffrey B.M., Molini B.J., Le H.T., Lukehart S.A., Centurion-Lara A., Rockey D.D.
    J. Bacteriol. 192:2645-2646(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ChicagoImported.

Entry informationi

Entry nameiD4GBA0_TREPC
AccessioniPrimary (citable) accession number: D4GBA0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 18, 2010
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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