D4DEJ7 (DPEP1_TRIVH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative dipeptidase TRV_05564
EC=3.4.13.19

Gene names

ORF Names:

TRV_05564

Organism

Trichophyton verrucosum (strain HKI 0517) [Complete proteome]

Taxonomic identifier

663202 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › Arthrodermataceae › mitosporic Arthrodermataceae › Trichophyton › Trichophyton verrucosum

Protein attributes

Sequence length	414 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes a wide range of dipeptides By similarity.
Catalytic activity	Hydrolysis of dipeptides.
Cofactor	Zinc By similarity.
Sequence similarities	Belongs to the peptidase M19 family.

Ontologies

Keywords
Domain	Signal
Ligand	Metal-binding Zinc
Molecular function	Dipeptidase Hydrolase Metalloprotease Protease
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	dipeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW dipeptidyl-peptidase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metalloexopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 414	394	Putative dipeptidase TRV_05564		PRO_0000411215
Sites
	Metal binding	45	1	Zinc 1; catalytic By similarity
	Metal binding	47	1	Zinc 1; catalytic By similarity
	Metal binding	157	1	Zinc 1; catalytic By similarity
	Metal binding	157	1	Zinc 2; catalytic By similarity
	Metal binding	228	1	Zinc 2; catalytic By similarity
	Metal binding	249	1	Zinc 2; catalytic By similarity
	Binding site	184	1	Substrate By similarity
	Binding site	260	1	Substrate By similarity
	Binding site	320	1	Substrate By similarity
Amino acid modifications
	Glycosylation	392	1	N-linked (GlcNAc...) Potential
	Disulfide bond	96 ↔ 186		By similarity

Sequences

	Sequence		Length	Mass (Da)
	D4DEJ7 [UniParc]. Last modified May 18, 2010. Version 1. Checksum: 938DC330AB7F222A	FASTA	414	45,407
	10 20 30 40 50 60 MAALFVSLLA LTSLVPVQGA ATVPQTDYAK RAERVLKSAP LIDGHNDLLY AIRRSTNDQI 70 80 90 100 110 120 YDGKLPFETS LKGHTDLPRM RKGRMGGQFW SVFIACPSDP NAPINTPKFA TRDTLEQIDV 130 140 150 160 170 180 ARRLVDKYSK DLMYCDNPGC AKRAFREGKI GSFIGIEGGH QVGSSIAALR QAFYAGARYM 190 200 210 220 230 240 TLTHNCDNAW ATAASTVRAG KPDLGMTDFG PALIKEMNRL GMLVDLSHVS HQTMRDVLKI 250 260 270 280 290 300 TKAPVIFSHS SAYEVSKHLR NVPDDVLKTV AKNNGVVMVT FVSSFVKVDD PDSADVNTVV 310 320 330 340 350 360 KHIFHIAEVA GWDHVGLGGD YDGTTELPKG LEDVSKYPYL IEKVLEAGAT EEQARKLVGE 370 380 390 400 410 NVLRVWTEVE QIAKKIQRSG VLPVEEVWKG RNGTALSERS TFIEGPAPLE YGCD

References

[1]

"Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi." Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S., Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M., Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O., Schroeckh V. , Hertweck C., Hube B., White T.C., Platzer M., Guthke R., Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A. Genome Biol. 12:R7.1-R7.16(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HKI 0517.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ACYE01000298 Genomic DNA. Translation: EFE39721.1.
RefSeq	XP_003020339.1. XM_003020293.1.
3D structure databases
ProteinModelPortal	D4DEJ7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9584076.
KEGG	tve:TRV_05564.
Phylogenomic databases
KO	K01273.
Family and domain databases
InterPro	IPR008257. Peptidase_M19. [Graphical view]
PANTHER	PTHR10443. PTHR10443. 1 hit.
Pfam	PF01244. Peptidase_M19. 1 hit. [Graphical view]
PROSITE	PS00869. RENAL_DIPEPTIDASE_1. False negative. PS51365. RENAL_DIPEPTIDASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DPEP1_TRIVH

Accession

Primary (citable) accession number: D4DEJ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	May 18, 2010
Last modified:	October 3, 2012
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program