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Protein

Putative dipeptidase TRV_05564

Gene

TRV_05564

Organism
Trichophyton verrucosum (strain HKI 0517)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes a wide range of dipeptides.By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zn2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi47Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi157Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi157Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei184SubstratePROSITE-ProRule annotation1
Metal bindingi228Zinc 2; catalyticPROSITE-ProRule annotation1
Metal bindingi249Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei260SubstratePROSITE-ProRule annotation1
Binding sitei320SubstratePROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative dipeptidase TRV_05564 (EC:3.4.13.19)
Gene namesi
ORF Names:TRV_05564
OrganismiTrichophyton verrucosum (strain HKI 0517)
Taxonomic identifieri663202 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeTrichophyton
Proteomesi
  • UP000008383 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000041121521 – 414Putative dipeptidase TRV_05564Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi96 ↔ 186PROSITE-ProRule annotation
Glycosylationi392N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi663202.XP_003020339.1.

Structurei

3D structure databases

ProteinModelPortaliD4DEJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4127. Eukaryota.
COG2355. LUCA.
KOiK01273.
OrthoDBiEOG092C2VQR.

Family and domain databases

CDDicd01301. rDP_like. 1 hit.
InterProiIPR032466. Metal_Hydrolase.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiPS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D4DEJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALFVSLLA LTSLVPVQGA ATVPQTDYAK RAERVLKSAP LIDGHNDLLY
60 70 80 90 100
AIRRSTNDQI YDGKLPFETS LKGHTDLPRM RKGRMGGQFW SVFIACPSDP
110 120 130 140 150
NAPINTPKFA TRDTLEQIDV ARRLVDKYSK DLMYCDNPGC AKRAFREGKI
160 170 180 190 200
GSFIGIEGGH QVGSSIAALR QAFYAGARYM TLTHNCDNAW ATAASTVRAG
210 220 230 240 250
KPDLGMTDFG PALIKEMNRL GMLVDLSHVS HQTMRDVLKI TKAPVIFSHS
260 270 280 290 300
SAYEVSKHLR NVPDDVLKTV AKNNGVVMVT FVSSFVKVDD PDSADVNTVV
310 320 330 340 350
KHIFHIAEVA GWDHVGLGGD YDGTTELPKG LEDVSKYPYL IEKVLEAGAT
360 370 380 390 400
EEQARKLVGE NVLRVWTEVE QIAKKIQRSG VLPVEEVWKG RNGTALSERS
410
TFIEGPAPLE YGCD
Length:414
Mass (Da):45,407
Last modified:May 18, 2010 - v1
Checksum:i938DC330AB7F222A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACYE01000298 Genomic DNA. Translation: EFE39721.1.
RefSeqiXP_003020339.1. XM_003020293.1.

Genome annotation databases

EnsemblFungiiEFE39721; EFE39721; TRV_05564.
GeneIDi9584076.
KEGGitve:TRV_05564.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACYE01000298 Genomic DNA. Translation: EFE39721.1.
RefSeqiXP_003020339.1. XM_003020293.1.

3D structure databases

ProteinModelPortaliD4DEJ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi663202.XP_003020339.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFE39721; EFE39721; TRV_05564.
GeneIDi9584076.
KEGGitve:TRV_05564.

Phylogenomic databases

eggNOGiKOG4127. Eukaryota.
COG2355. LUCA.
KOiK01273.
OrthoDBiEOG092C2VQR.

Family and domain databases

CDDicd01301. rDP_like. 1 hit.
InterProiIPR032466. Metal_Hydrolase.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiPS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPEP1_TRIVH
AccessioniPrimary (citable) accession number: D4DEJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.