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D4DD24

- SCPA_TRIVH

UniProt

D4DD24 - SCPA_TRIVH

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Protein
Carboxypeptidase S1 homolog A
Gene
SCPA, TRV_05031
Organism
Trichophyton verrucosum (strain HKI 0517)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Extracellular serine carboxypeptidase that contributes to pathogenicity By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei238 – 2381 By similarity
Active sitei458 – 4581 By similarity
Binding sitei461 – 4611Substrate By similarity
Active sitei516 – 5161 By similarity
Binding sitei517 – 5171Substrate By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Virulence

Protein family/group databases

MEROPSiS10.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase S1 homolog A (EC:3.4.16.6)
Alternative name(s):
Serine carboxypeptidase A
Short name:
SCPA
Gene namesi
Name:SCPA
ORF Names:TRV_05031
OrganismiTrichophyton verrucosum (strain HKI 0517)
Taxonomic identifieri663202 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaemitosporic ArthrodermataceaeTrichophyton
ProteomesiUP000008383: Unassembled WGS sequence

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor Reviewed prediction

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 629610Carboxypeptidase S1 homolog A
PRO_0000397825Add
BLAST
Propeptidei630 – 65223Removed in mature form Reviewed prediction
PRO_0000397826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 121 By similarity
Glycosylationi77 – 771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi132 – 1321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi161 – 1611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi168 – 1681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi184 – 1841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi202 – 2021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi260 – 2601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi299 – 2991N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi325 ↔ 361 By similarity
Disulfide bondi332 ↔ 354 By similarity
Glycosylationi347 – 3471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi410 – 4101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi474 – 4741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi492 – 4921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi505 – 5051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi594 – 5941N-linked (GlcNAc...) Reviewed prediction
Lipidationi629 – 6291GPI-anchor amidated glycine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG7FV40C.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D4DD24-1 [UniParc]FASTAAdd to Basket

« Hide

MRLAASIAVA LPVIGAASAQ GFPPPVTGVT VVKSKYDENV KITYKENDIC    50
ETTEGVRSFT GHVHLPPDND YFGVYQNYSI NTFFWFFEAR EDPKNAPLSI 100
WLNGGPGSSS MIGLFQENGP CWINDDSKST TNNSFSWNNR VNMLYIDQPN 150
QVGFSYDELT NITYSTINDT ISVADFSSGV PAQNLSTLVG TGSSQKPWAT 200
ANNTVNAARS IWHFAQVWFQ EFPEHKPNNN KISIWTESYG GRYGPSFASY 250
FQEQNEKIKN HTITKEGEMH ILNLDTLGVI NGCIDLMFQA ESYAEFPYNN 300
TYGITAYTKE KRDAIIRDIH RPDGCFDKLA KCREAAKEGD PHFYSNNATV 350
NAICAEANSD CDKYLMEPFQ EANLGYYDIA HPLQDPFPPP FFKGFLSQSS 400
VLSDMGSPVN FSHYSQAVGK SFHGVGDYAR PDVRGFTGDI AYLLESGVKV 450
ALVYGDRDYI CNWLGGEQVS LGLNYTGTEA FRKAGYADVK VNSSYVGGLV 500
RQHGNFSFTR VFEAGHEVPG YQPETSLKIF ERIMFNKDIA TGELDIAQKQ 550
DYGTTGTEST FQVKNEIPPS PEPTCYLLSA DGTCTPEQLN AIENGTAVVE 600
NYIIKSPAAS KGNPPPTTTS SPTASPTAGS AMLKAPVAML AISALTVLAF 650
YL 652
Length:652
Mass (Da):71,675
Last modified:May 18, 2010 - v1
Checksum:i09B03AAF0D8540FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACYE01000255 Genomic DNA. Translation: EFE40253.1.
RefSeqiXP_003020871.1. XM_003020825.1.

Genome annotation databases

GeneIDi9577701.
KEGGitve:TRV_05031.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACYE01000255 Genomic DNA. Translation: EFE40253.1 .
RefSeqi XP_003020871.1. XM_003020825.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9577701.
KEGGi tve:TRV_05031.

Phylogenomic databases

OrthoDBi EOG7FV40C.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 2 hits.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HKI 0517.

Entry informationi

Entry nameiSCPA_TRIVH
AccessioniPrimary (citable) accession number: D4DD24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: May 18, 2010
Last modified: June 11, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi