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Protein

Carboxypeptidase S1 homolog A

Gene

SCPA

Organism
Trichophyton verrucosum (strain HKI 0517)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Extracellular serine carboxypeptidase that contributes to pathogenicity.By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei238 – 2381PROSITE-ProRule annotation
Active sitei458 – 4581PROSITE-ProRule annotation
Binding sitei461 – 4611SubstrateBy similarity
Active sitei516 – 5161PROSITE-ProRule annotation
Binding sitei517 – 5171SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Virulence

Protein family/group databases

MEROPSiS10.A48.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase S1 homolog A (EC:3.4.16.6)
Alternative name(s):
Serine carboxypeptidase A
Short name:
SCPA
Gene namesi
Name:SCPA
ORF Names:TRV_05031
OrganismiTrichophyton verrucosum (strain HKI 0517)
Taxonomic identifieri663202 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeTrichophyton
ProteomesiUP000008383 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 629610Carboxypeptidase S1 homolog APRO_0000397825Add
BLAST
Propeptidei630 – 65223Removed in mature formSequence AnalysisPRO_0000397826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 121By similarity
Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi325 ↔ 361By similarity
Disulfide bondi332 ↔ 354By similarity
Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi594 – 5941N-linked (GlcNAc...)Sequence Analysis
Lipidationi629 – 6291GPI-anchor amidated glycineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG7FV40C.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D4DD24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLAASIAVA LPVIGAASAQ GFPPPVTGVT VVKSKYDENV KITYKENDIC
60 70 80 90 100
ETTEGVRSFT GHVHLPPDND YFGVYQNYSI NTFFWFFEAR EDPKNAPLSI
110 120 130 140 150
WLNGGPGSSS MIGLFQENGP CWINDDSKST TNNSFSWNNR VNMLYIDQPN
160 170 180 190 200
QVGFSYDELT NITYSTINDT ISVADFSSGV PAQNLSTLVG TGSSQKPWAT
210 220 230 240 250
ANNTVNAARS IWHFAQVWFQ EFPEHKPNNN KISIWTESYG GRYGPSFASY
260 270 280 290 300
FQEQNEKIKN HTITKEGEMH ILNLDTLGVI NGCIDLMFQA ESYAEFPYNN
310 320 330 340 350
TYGITAYTKE KRDAIIRDIH RPDGCFDKLA KCREAAKEGD PHFYSNNATV
360 370 380 390 400
NAICAEANSD CDKYLMEPFQ EANLGYYDIA HPLQDPFPPP FFKGFLSQSS
410 420 430 440 450
VLSDMGSPVN FSHYSQAVGK SFHGVGDYAR PDVRGFTGDI AYLLESGVKV
460 470 480 490 500
ALVYGDRDYI CNWLGGEQVS LGLNYTGTEA FRKAGYADVK VNSSYVGGLV
510 520 530 540 550
RQHGNFSFTR VFEAGHEVPG YQPETSLKIF ERIMFNKDIA TGELDIAQKQ
560 570 580 590 600
DYGTTGTEST FQVKNEIPPS PEPTCYLLSA DGTCTPEQLN AIENGTAVVE
610 620 630 640 650
NYIIKSPAAS KGNPPPTTTS SPTASPTAGS AMLKAPVAML AISALTVLAF

YL
Length:652
Mass (Da):71,675
Last modified:May 18, 2010 - v1
Checksum:i09B03AAF0D8540FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACYE01000255 Genomic DNA. Translation: EFE40253.1.
RefSeqiXP_003020871.1. XM_003020825.1.

Genome annotation databases

GeneIDi9577701.
KEGGitve:TRV_05031.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACYE01000255 Genomic DNA. Translation: EFE40253.1.
RefSeqiXP_003020871.1. XM_003020825.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS10.A48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9577701.
KEGGitve:TRV_05031.

Phylogenomic databases

OrthoDBiEOG7FV40C.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HKI 0517.

Entry informationi

Entry nameiSCPA_TRIVH
AccessioniPrimary (citable) accession number: D4DD24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: May 18, 2010
Last modified: March 4, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.