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D4DD06

- D4DD06_TRIVH

UniProt

D4DD06 - D4DD06_TRIVH

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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

TRV_05012

Organism
Trichophyton verrucosum (strain HKI 0517)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Binds 1 lipoyl cofactor covalently.
Binds 2 lipoyl cofactors covalently.
Binds 3 lipoyl cofactors covalently.

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyruvate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
ORF Names:TRV_05012Imported
OrganismiTrichophyton verrucosum (strain HKI 0517)Imported
Taxonomic identifieri663202 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeTrichophyton
ProteomesiUP000008383: Unassembled WGS genome

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
  2. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

LipoylUniRule annotation

Phylogenomic databases

KOiK00627.
OrthoDBiEOG7TTQJ2.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4DD06-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFINVVRSD ASTGNISNAY NWPSLCRFPQ RIRFPAKLNK IISVSEQTQS
60 70 80 90 100
RRREISRCPR SSHLQLLLSS IDLAPLGQLV CSLLSHPLIA DSIARFIPSR
110 120 130 140 150
QISTMASAAV LSRRLLLSKT AQHGLRESRN VLRLSDALSD IAYPPHTIIS
160 170 180 190 200
MPALSPTMTS GNIGAWNKKA GDTLSPGDVL VEIETDKAQM DFEFQDEGVL
210 220 230 240 250
AKILKDAGEK DVAVGNPIAV MVEEGEDISP FESFSLEDAG GDKAPAADKS
260 270 280 290 300
PKEAPKPEEA ETKAAPTPTF EENKPEAREA DTTGEKLQPS LDREPFVSPA
310 320 330 340 350
AKALALEKGV AIKDVKGTGP GGRVTKEDVE KHQASAPAAG AAGPAYEDVP
360 370 380 390 400
ASSMRKVIAS RLAQSIRENP HYFVSSTLSV TRLLKLRQAL NESSEGRYKL
410 420 430 440 450
SVNDFLIKAC AVALKRVPTV NSRWIEQNGQ VMIREHKTVD ISVAVATPSG
460 470 480 490 500
LITPIVKGVE GLGLSNISSQ VKDLGKRAKE NKLKPEEYNG GTFTISNMGM
510 520 530 540 550
NPAIERFTAV INPPQSAILA VGTTRKVAVR SELEEGTEIE WDDQIVVTGS
560 570 580
FDHKVIDGAI GAEFMRELKR VVENPLELLL
Length:580
Mass (Da):62,765
Last modified:May 18, 2010 - v1
Checksum:i81C14C4AA9AB8C5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACYE01000254 Genomic DNA. Translation: EFE40256.1.
RefSeqiXP_003020874.1. XM_003020828.1.

Genome annotation databases

GeneIDi9577713.
KEGGitve:TRV_05012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACYE01000254 Genomic DNA. Translation: EFE40256.1 .
RefSeqi XP_003020874.1. XM_003020828.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9577713.
KEGGi tve:TRV_05012.

Phylogenomic databases

KOi K00627.
OrthoDBi EOG7TTQJ2.

Family and domain databases

Gene3Di 3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsi TIGR01349. PDHac_trf_mito. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HKI 0517Imported.

Entry informationi

Entry nameiD4DD06_TRIVH
AccessioniPrimary (citable) accession number: D4DD06
Entry historyi
Integrated into UniProtKB/TrEMBL: May 18, 2010
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3