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D4DD06

- D4DD06_TRIVH

UniProt

D4DD06 - D4DD06_TRIVH

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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene
TRV_05012
Organism
Trichophyton verrucosum (strain HKI 0517)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2 By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Binds 1 lipoyl cofactor covalently By similarity.UniRule annotation
Binds 2 lipoyl cofactors covalently By similarity.UniRule annotation
Binds 3 lipoyl cofactors covalently By similarity.UniRule annotation

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: InterPro

GO - Biological processi

  1. pyruvate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
ORF Names:TRV_05012Imported
OrganismiTrichophyton verrucosum (strain HKI 0517)
Taxonomic identifieri663202 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaemitosporic ArthrodermataceaeTrichophyton
ProteomesiUP000008383: Unassembled WGS genome

Subcellular locationi

Mitochondrion matrix By similarity UniRule annotation

GO - Cellular componenti

  1. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

LipoylUniRule annotation

Phylogenomic databases

KOiK00627.
OrthoDBiEOG7TTQJ2.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4DD06-1 [UniParc]FASTAAdd to Basket

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MSFINVVRSD ASTGNISNAY NWPSLCRFPQ RIRFPAKLNK IISVSEQTQS    50
RRREISRCPR SSHLQLLLSS IDLAPLGQLV CSLLSHPLIA DSIARFIPSR 100
QISTMASAAV LSRRLLLSKT AQHGLRESRN VLRLSDALSD IAYPPHTIIS 150
MPALSPTMTS GNIGAWNKKA GDTLSPGDVL VEIETDKAQM DFEFQDEGVL 200
AKILKDAGEK DVAVGNPIAV MVEEGEDISP FESFSLEDAG GDKAPAADKS 250
PKEAPKPEEA ETKAAPTPTF EENKPEAREA DTTGEKLQPS LDREPFVSPA 300
AKALALEKGV AIKDVKGTGP GGRVTKEDVE KHQASAPAAG AAGPAYEDVP 350
ASSMRKVIAS RLAQSIRENP HYFVSSTLSV TRLLKLRQAL NESSEGRYKL 400
SVNDFLIKAC AVALKRVPTV NSRWIEQNGQ VMIREHKTVD ISVAVATPSG 450
LITPIVKGVE GLGLSNISSQ VKDLGKRAKE NKLKPEEYNG GTFTISNMGM 500
NPAIERFTAV INPPQSAILA VGTTRKVAVR SELEEGTEIE WDDQIVVTGS 550
FDHKVIDGAI GAEFMRELKR VVENPLELLL 580
Length:580
Mass (Da):62,765
Last modified:May 18, 2010 - v1
Checksum:i81C14C4AA9AB8C5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACYE01000254 Genomic DNA. Translation: EFE40256.1.
RefSeqiXP_003020874.1. XM_003020828.1.

Genome annotation databases

GeneIDi9577713.
KEGGitve:TRV_05012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACYE01000254 Genomic DNA. Translation: EFE40256.1 .
RefSeqi XP_003020874.1. XM_003020828.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9577713.
KEGGi tve:TRV_05012.

Phylogenomic databases

KOi K00627.
OrthoDBi EOG7TTQJ2.

Family and domain databases

Gene3Di 3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsi TIGR01349. PDHac_trf_mito. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HKI 0517.

Entry informationi

Entry nameiD4DD06_TRIVH
AccessioniPrimary (citable) accession number: D4DD06
Entry historyi
Integrated into UniProtKB/TrEMBL: May 18, 2010
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi