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D4DD06

- D4DD06_TRIVH

UniProt

D4DD06 - D4DD06_TRIVH

Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

TRV_05012

Organism
Trichophyton verrucosum (strain HKI 0517)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (18 May 2010)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

    Cofactori

    Binds 1 lipoyl cofactor covalently.UniRule annotation
    Binds 2 lipoyl cofactors covalently.UniRule annotation
    Binds 3 lipoyl cofactors covalently.UniRule annotation

    GO - Molecular functioni

    1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyruvate metabolic process Source: InterPro

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotation, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
    Gene namesi
    ORF Names:TRV_05012Imported
    OrganismiTrichophyton verrucosum (strain HKI 0517)Imported
    Taxonomic identifieri663202 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaemitosporic ArthrodermataceaeTrichophyton
    ProteomesiUP000008383: Unassembled WGS genome

    Subcellular locationi

    Mitochondrion matrix UniRule annotation

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. pyruvate dehydrogenase complex Source: InterPro

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 lipoyl-binding domain.UniRule annotation

    Keywords - Domaini

    LipoylUniRule annotation

    Phylogenomic databases

    KOiK00627.
    OrthoDBiEOG7TTQJ2.

    Family and domain databases

    Gene3Di3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR006257. LAT1.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF02817. E3_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 1 hit.
    TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
    PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00189. LIPOYL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D4DD06-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFINVVRSD ASTGNISNAY NWPSLCRFPQ RIRFPAKLNK IISVSEQTQS    50
    RRREISRCPR SSHLQLLLSS IDLAPLGQLV CSLLSHPLIA DSIARFIPSR 100
    QISTMASAAV LSRRLLLSKT AQHGLRESRN VLRLSDALSD IAYPPHTIIS 150
    MPALSPTMTS GNIGAWNKKA GDTLSPGDVL VEIETDKAQM DFEFQDEGVL 200
    AKILKDAGEK DVAVGNPIAV MVEEGEDISP FESFSLEDAG GDKAPAADKS 250
    PKEAPKPEEA ETKAAPTPTF EENKPEAREA DTTGEKLQPS LDREPFVSPA 300
    AKALALEKGV AIKDVKGTGP GGRVTKEDVE KHQASAPAAG AAGPAYEDVP 350
    ASSMRKVIAS RLAQSIRENP HYFVSSTLSV TRLLKLRQAL NESSEGRYKL 400
    SVNDFLIKAC AVALKRVPTV NSRWIEQNGQ VMIREHKTVD ISVAVATPSG 450
    LITPIVKGVE GLGLSNISSQ VKDLGKRAKE NKLKPEEYNG GTFTISNMGM 500
    NPAIERFTAV INPPQSAILA VGTTRKVAVR SELEEGTEIE WDDQIVVTGS 550
    FDHKVIDGAI GAEFMRELKR VVENPLELLL 580
    Length:580
    Mass (Da):62,765
    Last modified:May 18, 2010 - v1
    Checksum:i81C14C4AA9AB8C5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACYE01000254 Genomic DNA. Translation: EFE40256.1.
    RefSeqiXP_003020874.1. XM_003020828.1.

    Genome annotation databases

    GeneIDi9577713.
    KEGGitve:TRV_05012.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACYE01000254 Genomic DNA. Translation: EFE40256.1 .
    RefSeqi XP_003020874.1. XM_003020828.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9577713.
    KEGGi tve:TRV_05012.

    Phylogenomic databases

    KOi K00627.
    OrthoDBi EOG7TTQJ2.

    Family and domain databases

    Gene3Di 3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR006257. LAT1.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF02817. E3_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 1 hit.
    TIGRFAMsi TIGR01349. PDHac_trf_mito. 1 hit.
    PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00189. LIPOYL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HKI 0517Imported.

    Entry informationi

    Entry nameiD4DD06_TRIVH
    AccessioniPrimary (citable) accession number: D4DD06
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 18, 2010
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3