Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

TRV_05012

Organism
Trichophyton verrucosum (strain HKI 0517)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
ORF Names:TRV_05012Imported
OrganismiTrichophyton verrucosum (strain HKI 0517)Imported
Taxonomic identifieri663202 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeTrichophyton
Proteomesi
  • UP000008383 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

Protein-protein interaction databases

STRINGi663202.XP_003020874.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 222Lipoyl-bindingInterPro annotationAdd BLAST77
Domaini296 – 333Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotation

Phylogenomic databases

eggNOGiKOG0557 Eukaryota
COG0508 LUCA
KOiK00627
OrthoDBiEOG092C32CQ

Family and domain databases

Gene3Di3.30.559.10, 1 hit
4.10.320.10, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR006257 LAT1
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 1 hit
TIGRFAMsiTIGR01349 PDHac_trf_mito, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00189 LIPOYL, 1 hit
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

D4DD06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFINVVRSD ASTGNISNAY NWPSLCRFPQ RIRFPAKLNK IISVSEQTQS
60 70 80 90 100
RRREISRCPR SSHLQLLLSS IDLAPLGQLV CSLLSHPLIA DSIARFIPSR
110 120 130 140 150
QISTMASAAV LSRRLLLSKT AQHGLRESRN VLRLSDALSD IAYPPHTIIS
160 170 180 190 200
MPALSPTMTS GNIGAWNKKA GDTLSPGDVL VEIETDKAQM DFEFQDEGVL
210 220 230 240 250
AKILKDAGEK DVAVGNPIAV MVEEGEDISP FESFSLEDAG GDKAPAADKS
260 270 280 290 300
PKEAPKPEEA ETKAAPTPTF EENKPEAREA DTTGEKLQPS LDREPFVSPA
310 320 330 340 350
AKALALEKGV AIKDVKGTGP GGRVTKEDVE KHQASAPAAG AAGPAYEDVP
360 370 380 390 400
ASSMRKVIAS RLAQSIRENP HYFVSSTLSV TRLLKLRQAL NESSEGRYKL
410 420 430 440 450
SVNDFLIKAC AVALKRVPTV NSRWIEQNGQ VMIREHKTVD ISVAVATPSG
460 470 480 490 500
LITPIVKGVE GLGLSNISSQ VKDLGKRAKE NKLKPEEYNG GTFTISNMGM
510 520 530 540 550
NPAIERFTAV INPPQSAILA VGTTRKVAVR SELEEGTEIE WDDQIVVTGS
560 570 580
FDHKVIDGAI GAEFMRELKR VVENPLELLL
Length:580
Mass (Da):62,765
Last modified:May 18, 2010 - v1
Checksum:i81C14C4AA9AB8C5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACYE01000254 Genomic DNA Translation: EFE40256.1
RefSeqiXP_003020874.1, XM_003020828.1

Genome annotation databases

EnsemblFungiiEFE40256; EFE40256; TRV_05012
GeneIDi9577713
KEGGitve:TRV_05012

Similar proteinsi

Entry informationi

Entry nameiD4DD06_TRIVH
AccessioniPrimary (citable) accession number: D4DD06
Entry historyiIntegrated into UniProtKB/TrEMBL: May 18, 2010
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health