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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

TRV_05012

Organism
Trichophyton verrucosum (strain HKI 0517)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • (R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation
  • (R)-lipoateUniRule annotationNote: Binds 2 lipoyl cofactors covalently.UniRule annotation
  • (R)-lipoateUniRule annotationNote: Binds 3 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyruvate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
ORF Names:TRV_05012Imported
OrganismiTrichophyton verrucosum (strain HKI 0517)Imported
Taxonomic identifieri663202 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeTrichophyton
ProteomesiUP000008383 Componenti: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix UniRule annotation

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
  2. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

LipoylUniRule annotation

Phylogenomic databases

KOiK00627.
OrthoDBiEOG7TTQJ2.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4DD06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFINVVRSD ASTGNISNAY NWPSLCRFPQ RIRFPAKLNK IISVSEQTQS
60 70 80 90 100
RRREISRCPR SSHLQLLLSS IDLAPLGQLV CSLLSHPLIA DSIARFIPSR
110 120 130 140 150
QISTMASAAV LSRRLLLSKT AQHGLRESRN VLRLSDALSD IAYPPHTIIS
160 170 180 190 200
MPALSPTMTS GNIGAWNKKA GDTLSPGDVL VEIETDKAQM DFEFQDEGVL
210 220 230 240 250
AKILKDAGEK DVAVGNPIAV MVEEGEDISP FESFSLEDAG GDKAPAADKS
260 270 280 290 300
PKEAPKPEEA ETKAAPTPTF EENKPEAREA DTTGEKLQPS LDREPFVSPA
310 320 330 340 350
AKALALEKGV AIKDVKGTGP GGRVTKEDVE KHQASAPAAG AAGPAYEDVP
360 370 380 390 400
ASSMRKVIAS RLAQSIRENP HYFVSSTLSV TRLLKLRQAL NESSEGRYKL
410 420 430 440 450
SVNDFLIKAC AVALKRVPTV NSRWIEQNGQ VMIREHKTVD ISVAVATPSG
460 470 480 490 500
LITPIVKGVE GLGLSNISSQ VKDLGKRAKE NKLKPEEYNG GTFTISNMGM
510 520 530 540 550
NPAIERFTAV INPPQSAILA VGTTRKVAVR SELEEGTEIE WDDQIVVTGS
560 570 580
FDHKVIDGAI GAEFMRELKR VVENPLELLL
Length:580
Mass (Da):62,765
Last modified:May 17, 2010 - v1
Checksum:i81C14C4AA9AB8C5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACYE01000254 Genomic DNA. Translation: EFE40256.1.
RefSeqiXP_003020874.1. XM_003020828.1.

Genome annotation databases

GeneIDi9577713.
KEGGitve:TRV_05012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACYE01000254 Genomic DNA. Translation: EFE40256.1.
RefSeqiXP_003020874.1. XM_003020828.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9577713.
KEGGitve:TRV_05012.

Phylogenomic databases

KOiK00627.
OrthoDBiEOG7TTQJ2.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HKI 0517Imported.

Entry informationi

Entry nameiD4DD06_TRIVH
AccessioniPrimary (citable) accession number: D4DD06
Entry historyi
Integrated into UniProtKB/TrEMBL: May 17, 2010
Last sequence update: May 17, 2010
Last modified: March 3, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.