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D4DCG0

- DAPB_TRIVH

UniProt

D4DCG0 - DAPB_TRIVH

Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Trichophyton verrucosum (strain HKI 0517)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (18 May 2010)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei765 – 7651Charge relay systemPROSITE-ProRule annotation
    Active sitei842 – 8421Charge relay systemPROSITE-ProRule annotation
    Active sitei875 – 8751Charge relay systemPROSITE-ProRule annotation

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:DAPB
    ORF Names:TRV_04813
    OrganismiTrichophyton verrucosum (strain HKI 0517)
    Taxonomic identifieri663202 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaemitosporic ArthrodermataceaeTrichophyton
    ProteomesiUP000008383: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 899899Probable dipeptidyl-aminopeptidase BPRO_0000412165Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi819 – 8191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi824 – 8241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi827 – 8271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi893 – 8931N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliD4DCG0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9999CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini121 – 899779VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei100 – 12021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK01282.
    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002471. Pept_S9_AS.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D4DCG0-1 [UniParc]FASTAAdd to Basket

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    MKLDRMRVGS RINDEEAMPL TAPESRARDS IDSSSTASIS LTLVEGASHA    50
    TTEPSKPAHN HNGRTQGNYA EKYRDDLEED WEENNYIPTN GKSSQRRTLI 100
    VFWLLVALCV GGWAVAFLFF VTSPGNKTST SPHSGSNSPE GDVTKPGIPA 150
    TGKKIPLDDA IGGVWSPAEH TISWIAGAKG EDGLLLQKSE GGTGPYLHVE 200
    DVRNIHGTQS NNNSIVLMKE SVFFVNDERI SPEKVWPSPD LKTVLAMTRE 250
    KKNWRHSFTG LYWLFDVETQ TAQPLDPDAP NGRIQLATWS PTSDAVAFTR 300
    DNNLYIRNLT SKSVKAITTD GGTNLFYGIP DWVYEEEVFE GNIATWWSLD 350
    GKYISYLRTN ETLVPEFPID FYLSSPPGYS PKPGEESYPY VQQIKYPKAG 400
    APNPTVSLQF YDIEREESFS VDVKDTLKDD DRLIVEVIPG SKGKVLVRET 450
    NRESYIVKVA VIDANKREGK IVRSDNIDEI DGGWVEPSHT TTYIPADPSA 500
    GRPDDGYIDT VIHEGYIHLA YFTPLENPKP KMLTTGKWEV VAAPSGVDLK 550
    NNVVYFVATK ESPIDRHVYS VKLDGSELRM LKDSDKSAYY DVSFSHGAGY 600
    MLLKYQGPQI PWQKLISSPS NADNYIEILE ENKKLAKLSN EFALPSLHYS 650
    TITVDGFELP VVERRPPNFD ETKKYPVLFQ LYGGPGSQTV NKKFLVNFQT 700
    YVASNLGYIV VTVDGRGTGF NGRKFKCIVR RNLGHYEAHD QIQAAKAWGK 750
    KPYVDKTRMA IWGWSYGGFM TLKTLEQDAG ETFQYGMAVA PVTNWRYYDS 800
    VYTERYMHMP QNNEGGYENA SISNATNLSQ NTRFLIMHGS ADDNVHFQNT 850
    LTLLDKLDIL GVHNYDMHVF PDSNHGIYFH HAYKMVHQRK YFNLSFLGH 899
    Length:899
    Mass (Da):101,076
    Last modified:May 18, 2010 - v1
    Checksum:iCD9AF2AD45BBFCB8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACYE01000244 Genomic DNA. Translation: EFE40482.1.
    RefSeqiXP_003021100.1. XM_003021054.1.

    Genome annotation databases

    GeneIDi9577942.
    KEGGitve:TRV_04813.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACYE01000244 Genomic DNA. Translation: EFE40482.1 .
    RefSeqi XP_003021100.1. XM_003021054.1.

    3D structure databases

    ProteinModelPortali D4DCG0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9577942.
    KEGGi tve:TRV_04813.

    Phylogenomic databases

    KOi K01282.
    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002471. Pept_S9_AS.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HKI 0517.

    Entry informationi

    Entry nameiDAPB_TRIVH
    AccessioniPrimary (citable) accession number: D4DCG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3