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D4DCG0

- DAPB_TRIVH

UniProt

D4DCG0 - DAPB_TRIVH

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Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Trichophyton verrucosum (strain HKI 0517)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei765 – 7651Charge relay systemPROSITE-ProRule annotation
Active sitei842 – 8421Charge relay systemPROSITE-ProRule annotation
Active sitei875 – 8751Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:TRV_04813
OrganismiTrichophyton verrucosum (strain HKI 0517)
Taxonomic identifieri663202 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeTrichophyton
ProteomesiUP000008383: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9999CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini121 – 899779VacuolarSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 899899Probable dipeptidyl-aminopeptidase BPRO_0000412165Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi819 – 8191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi824 – 8241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi827 – 8271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi893 – 8931N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliD4DCG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01282.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4DCG0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLDRMRVGS RINDEEAMPL TAPESRARDS IDSSSTASIS LTLVEGASHA
60 70 80 90 100
TTEPSKPAHN HNGRTQGNYA EKYRDDLEED WEENNYIPTN GKSSQRRTLI
110 120 130 140 150
VFWLLVALCV GGWAVAFLFF VTSPGNKTST SPHSGSNSPE GDVTKPGIPA
160 170 180 190 200
TGKKIPLDDA IGGVWSPAEH TISWIAGAKG EDGLLLQKSE GGTGPYLHVE
210 220 230 240 250
DVRNIHGTQS NNNSIVLMKE SVFFVNDERI SPEKVWPSPD LKTVLAMTRE
260 270 280 290 300
KKNWRHSFTG LYWLFDVETQ TAQPLDPDAP NGRIQLATWS PTSDAVAFTR
310 320 330 340 350
DNNLYIRNLT SKSVKAITTD GGTNLFYGIP DWVYEEEVFE GNIATWWSLD
360 370 380 390 400
GKYISYLRTN ETLVPEFPID FYLSSPPGYS PKPGEESYPY VQQIKYPKAG
410 420 430 440 450
APNPTVSLQF YDIEREESFS VDVKDTLKDD DRLIVEVIPG SKGKVLVRET
460 470 480 490 500
NRESYIVKVA VIDANKREGK IVRSDNIDEI DGGWVEPSHT TTYIPADPSA
510 520 530 540 550
GRPDDGYIDT VIHEGYIHLA YFTPLENPKP KMLTTGKWEV VAAPSGVDLK
560 570 580 590 600
NNVVYFVATK ESPIDRHVYS VKLDGSELRM LKDSDKSAYY DVSFSHGAGY
610 620 630 640 650
MLLKYQGPQI PWQKLISSPS NADNYIEILE ENKKLAKLSN EFALPSLHYS
660 670 680 690 700
TITVDGFELP VVERRPPNFD ETKKYPVLFQ LYGGPGSQTV NKKFLVNFQT
710 720 730 740 750
YVASNLGYIV VTVDGRGTGF NGRKFKCIVR RNLGHYEAHD QIQAAKAWGK
760 770 780 790 800
KPYVDKTRMA IWGWSYGGFM TLKTLEQDAG ETFQYGMAVA PVTNWRYYDS
810 820 830 840 850
VYTERYMHMP QNNEGGYENA SISNATNLSQ NTRFLIMHGS ADDNVHFQNT
860 870 880 890
LTLLDKLDIL GVHNYDMHVF PDSNHGIYFH HAYKMVHQRK YFNLSFLGH
Length:899
Mass (Da):101,076
Last modified:May 18, 2010 - v1
Checksum:iCD9AF2AD45BBFCB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACYE01000244 Genomic DNA. Translation: EFE40482.1.
RefSeqiXP_003021100.1. XM_003021054.1.

Genome annotation databases

GeneIDi9577942.
KEGGitve:TRV_04813.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACYE01000244 Genomic DNA. Translation: EFE40482.1 .
RefSeqi XP_003021100.1. XM_003021054.1.

3D structure databases

ProteinModelPortali D4DCG0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9577942.
KEGGi tve:TRV_04813.

Phylogenomic databases

KOi K01282.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HKI 0517.

Entry informationi

Entry nameiDAPB_TRIVH
AccessioniPrimary (citable) accession number: D4DCG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3