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D4DCG0

- DAPB_TRIVH

UniProt

D4DCG0 - DAPB_TRIVH

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Protein

Probable dipeptidyl-aminopeptidase B

Gene
DAPB, TRV_04813
Organism
Trichophyton verrucosum (strain HKI 0517)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei765 – 7651Charge relay system By similarity
Active sitei842 – 8421Charge relay system By similarity
Active sitei875 – 8751Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:TRV_04813
OrganismiTrichophyton verrucosum (strain HKI 0517)
Taxonomic identifieri663202 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaemitosporic ArthrodermataceaeTrichophyton
ProteomesiUP000008383: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9999Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei100 – 12021Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini121 – 899779Vacuolar Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 899899Probable dipeptidyl-aminopeptidase BPRO_0000412165Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi212 – 2121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi308 – 3081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi360 – 3601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi819 – 8191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi824 – 8241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi827 – 8271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi893 – 8931N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliD4DCG0.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01282.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4DCG0-1 [UniParc]FASTAAdd to Basket

« Hide

MKLDRMRVGS RINDEEAMPL TAPESRARDS IDSSSTASIS LTLVEGASHA    50
TTEPSKPAHN HNGRTQGNYA EKYRDDLEED WEENNYIPTN GKSSQRRTLI 100
VFWLLVALCV GGWAVAFLFF VTSPGNKTST SPHSGSNSPE GDVTKPGIPA 150
TGKKIPLDDA IGGVWSPAEH TISWIAGAKG EDGLLLQKSE GGTGPYLHVE 200
DVRNIHGTQS NNNSIVLMKE SVFFVNDERI SPEKVWPSPD LKTVLAMTRE 250
KKNWRHSFTG LYWLFDVETQ TAQPLDPDAP NGRIQLATWS PTSDAVAFTR 300
DNNLYIRNLT SKSVKAITTD GGTNLFYGIP DWVYEEEVFE GNIATWWSLD 350
GKYISYLRTN ETLVPEFPID FYLSSPPGYS PKPGEESYPY VQQIKYPKAG 400
APNPTVSLQF YDIEREESFS VDVKDTLKDD DRLIVEVIPG SKGKVLVRET 450
NRESYIVKVA VIDANKREGK IVRSDNIDEI DGGWVEPSHT TTYIPADPSA 500
GRPDDGYIDT VIHEGYIHLA YFTPLENPKP KMLTTGKWEV VAAPSGVDLK 550
NNVVYFVATK ESPIDRHVYS VKLDGSELRM LKDSDKSAYY DVSFSHGAGY 600
MLLKYQGPQI PWQKLISSPS NADNYIEILE ENKKLAKLSN EFALPSLHYS 650
TITVDGFELP VVERRPPNFD ETKKYPVLFQ LYGGPGSQTV NKKFLVNFQT 700
YVASNLGYIV VTVDGRGTGF NGRKFKCIVR RNLGHYEAHD QIQAAKAWGK 750
KPYVDKTRMA IWGWSYGGFM TLKTLEQDAG ETFQYGMAVA PVTNWRYYDS 800
VYTERYMHMP QNNEGGYENA SISNATNLSQ NTRFLIMHGS ADDNVHFQNT 850
LTLLDKLDIL GVHNYDMHVF PDSNHGIYFH HAYKMVHQRK YFNLSFLGH 899
Length:899
Mass (Da):101,076
Last modified:May 18, 2010 - v1
Checksum:iCD9AF2AD45BBFCB8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACYE01000244 Genomic DNA. Translation: EFE40482.1.
RefSeqiXP_003021100.1. XM_003021054.1.

Genome annotation databases

GeneIDi9577942.
KEGGitve:TRV_04813.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACYE01000244 Genomic DNA. Translation: EFE40482.1 .
RefSeqi XP_003021100.1. XM_003021054.1.

3D structure databases

ProteinModelPortali D4DCG0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9577942.
KEGGi tve:TRV_04813.

Phylogenomic databases

KOi K01282.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HKI 0517.

Entry informationi

Entry nameiDAPB_TRIVH
AccessioniPrimary (citable) accession number: D4DCG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 18, 2010
Last modified: June 11, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi