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D4DCG0 (DAPB_TRIVH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:DAPB
ORF Names:TRV_04813
OrganismTrichophyton verrucosum (strain HKI 0517) [Complete proteome]
Taxonomic identifier663202 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaemitosporic ArthrodermataceaeTrichophyton

Protein attributes

Sequence length899 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 899899Probable dipeptidyl-aminopeptidase B
PRO_0000412165

Regions

Topological domain1 – 9999Cytoplasmic Potential
Transmembrane100 – 12021Helical; Signal-anchor for type II membrane protein; Potential
Topological domain121 – 899779Vacuolar Potential

Sites

Active site7651Charge relay system By similarity
Active site8421Charge relay system By similarity
Active site8751Charge relay system By similarity

Amino acid modifications

Glycosylation2121N-linked (GlcNAc...) Potential
Glycosylation3081N-linked (GlcNAc...) Potential
Glycosylation3601N-linked (GlcNAc...) Potential
Glycosylation8191N-linked (GlcNAc...) Potential
Glycosylation8241N-linked (GlcNAc...) Potential
Glycosylation8271N-linked (GlcNAc...) Potential
Glycosylation8931N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
D4DCG0 [UniParc].

Last modified May 18, 2010. Version 1.
Checksum: CD9AF2AD45BBFCB8

FASTA899101,076
        10         20         30         40         50         60 
MKLDRMRVGS RINDEEAMPL TAPESRARDS IDSSSTASIS LTLVEGASHA TTEPSKPAHN 

        70         80         90        100        110        120 
HNGRTQGNYA EKYRDDLEED WEENNYIPTN GKSSQRRTLI VFWLLVALCV GGWAVAFLFF 

       130        140        150        160        170        180 
VTSPGNKTST SPHSGSNSPE GDVTKPGIPA TGKKIPLDDA IGGVWSPAEH TISWIAGAKG 

       190        200        210        220        230        240 
EDGLLLQKSE GGTGPYLHVE DVRNIHGTQS NNNSIVLMKE SVFFVNDERI SPEKVWPSPD 

       250        260        270        280        290        300 
LKTVLAMTRE KKNWRHSFTG LYWLFDVETQ TAQPLDPDAP NGRIQLATWS PTSDAVAFTR 

       310        320        330        340        350        360 
DNNLYIRNLT SKSVKAITTD GGTNLFYGIP DWVYEEEVFE GNIATWWSLD GKYISYLRTN 

       370        380        390        400        410        420 
ETLVPEFPID FYLSSPPGYS PKPGEESYPY VQQIKYPKAG APNPTVSLQF YDIEREESFS 

       430        440        450        460        470        480 
VDVKDTLKDD DRLIVEVIPG SKGKVLVRET NRESYIVKVA VIDANKREGK IVRSDNIDEI 

       490        500        510        520        530        540 
DGGWVEPSHT TTYIPADPSA GRPDDGYIDT VIHEGYIHLA YFTPLENPKP KMLTTGKWEV 

       550        560        570        580        590        600 
VAAPSGVDLK NNVVYFVATK ESPIDRHVYS VKLDGSELRM LKDSDKSAYY DVSFSHGAGY 

       610        620        630        640        650        660 
MLLKYQGPQI PWQKLISSPS NADNYIEILE ENKKLAKLSN EFALPSLHYS TITVDGFELP 

       670        680        690        700        710        720 
VVERRPPNFD ETKKYPVLFQ LYGGPGSQTV NKKFLVNFQT YVASNLGYIV VTVDGRGTGF 

       730        740        750        760        770        780 
NGRKFKCIVR RNLGHYEAHD QIQAAKAWGK KPYVDKTRMA IWGWSYGGFM TLKTLEQDAG 

       790        800        810        820        830        840 
ETFQYGMAVA PVTNWRYYDS VYTERYMHMP QNNEGGYENA SISNATNLSQ NTRFLIMHGS 

       850        860        870        880        890 
ADDNVHFQNT LTLLDKLDIL GVHNYDMHVF PDSNHGIYFH HAYKMVHQRK YFNLSFLGH 

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References

[1]"Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi."
Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S., Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M., Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O., Schroeckh V. expand/collapse author list , Hertweck C., Hube B., White T.C., Platzer M., Guthke R., Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.
Genome Biol. 12:R7.1-R7.16(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HKI 0517.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
ACYE01000244 Genomic DNA. Translation: EFE40482.1.
RefSeqXP_003021100.1. XM_003021054.1.

3D structure databases

ProteinModelPortalD4DCG0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9577942.
KEGGtve:TRV_04813.

Phylogenomic databases

KOK01282.
OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
InterProIPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
PROSITEPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_TRIVH
AccessionPrimary (citable) accession number: D4DCG0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries