D4D891 (AMPP1_TRIVH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase P
Short name=AMPP
Short name=Aminopeptidase P
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	AMPP
ORF Names:	TRV_03327

Organism

Trichophyton verrucosum (strain HKI 0517) [Complete proteome]

Taxonomic identifier

663202 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › Arthrodermataceae › mitosporic Arthrodermataceae › Trichophyton › Trichophyton verrucosum

Protein attributes

Sequence length	698 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.
Sequence caution	The sequence EFE41910.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 698	698	Probable Xaa-Pro aminopeptidase P		PRO_0000411812
Sites
	Metal binding	509	1	Manganese 2 By similarity
	Metal binding	520	1	Manganese 1 By similarity
	Metal binding	520	1	Manganese 2 By similarity
	Metal binding	604	1	Manganese 1 By similarity
	Metal binding	618	1	Manganese 1 By similarity
	Metal binding	618	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	D4D891 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: C74FC33E0CBA2CBD	FASTA	698	77,470
	10 20 30 40 50 60 MTIFRPHLRF LFKPHFLYFQ SPAGQSSRPF STSQILRTAL DMPPPPVDTT QRLAKLRELM 70 80 90 100 110 120 AQNKVDVYSM QFRYTIKAPL IITVVYSFFF FLLLALKLCL RKTAISQSTL LHVMGVETLI 130 140 150 160 170 180 RITAAFISSF TGSAGCAIVS MSKAALSTDG RYFSQAAKQL DSNWTLLKRG VEGVPTWEEW 190 200 210 220 230 240 TAEQAENGKV VGVDPSLITA GENLHYTPLT SVVVTNCSYV IADARKLSQT LKTTGGSLVG 250 260 270 280 290 300 IDQNLIDAVW GNERPARPAN QITVQPVERA GKPFEEKVED LRKELAAKKR SAMVISTLDE 310 320 330 340 350 360 IAWLFNLRGS DIPYNPVFFS YAIVTPSVAE LYVDESKLSP EARKHLEGKV VLKPYDSIFQ 370 380 390 400 410 420 ASKVLAESKA SASSGSSGKF LLSNKASWSL SLALGGEQNV VEVRSPITDA KAIKNEVELE 430 440 450 460 470 480 GFRKCHIRDG AALIEYFAWL ENALIKEGAQ LDEVDGADKL FEIRKKYDLF VGNSFDTISS 490 500 510 520 530 540 TGANGATIHY KPEKSTCAVI DPKAMYLCDS GGQYLDGTTD TTRTLHFGEP TEFQKKAYAL 550 560 570 580 590 600 VLKGHISIDN AIFPKGTTGY AIDSFARQHL WKEGLDYLHG TGHGVGSFLY AEVPLSASNV 610 620 630 640 650 660 LSNEPGYYED GNFGIRLENL VICKEVQTAH KFGDKPFLGF ESITLVPFCQ KLLDASLLTE 670 680 690 AERKWVNDYH ARVWEKTSPF FEKDELTTAW LKRETQPI

References

[1]

"Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi." Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S., Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M., Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O., Schroeckh V. , Hertweck C., Hube B., White T.C., Platzer M., Guthke R., Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A. Genome Biol. 12:R7.1-R7.16(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HKI 0517.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ACYE01000172 Genomic DNA. Translation: EFE41910.1. Sequence problems.
RefSeq	XP_003022528.1. XM_003022482.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9581105.
KEGG	tve:TRV_03327.
Phylogenomic databases
KO	K01262.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR000587. Creatinase. IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF01321. Creatinase_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP1_TRIVH

Accession

Primary (citable) accession number: D4D891

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	July 27, 2011
Last modified:	March 6, 2013
This is version 22 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program