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D4D802

- LCPS_TRIVH

UniProt

D4D802 - LCPS_TRIVH

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Protein
Bifunctional lycopene cyclase/phytoene synthase
Gene
TRV_03236
Organism
Trichophyton verrucosum (strain HKI 0517)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase) By similarity.

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.
2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathwayi

GO - Molecular functioni

  1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB-EC
  2. intramolecular lyase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. carotenoid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Transferase

Keywords - Biological processi

Carotenoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.
UPA00802.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lycopene cyclase/phytoene synthase
Including the following 2 domains:
Lycopene beta-cyclase (EC:5.5.1.19)
Alternative name(s):
Lycopene cyclase
Phytoene synthase (EC:2.5.1.32)
Gene namesi
ORF Names:TRV_03236
OrganismiTrichophyton verrucosum (strain HKI 0517)
Taxonomic identifieri663202 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaemitosporic ArthrodermataceaeTrichophyton
ProteomesiUP000008383: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321Helical; Reviewed prediction
Add
BLAST
Transmembranei35 – 5521Helical; Reviewed prediction
Add
BLAST
Transmembranei77 – 9721Helical; Reviewed prediction
Add
BLAST
Transmembranei130 – 15021Helical; Reviewed prediction
Add
BLAST
Transmembranei153 – 17321Helical; Reviewed prediction
Add
BLAST
Transmembranei176 – 19621Helical; Reviewed prediction
Add
BLAST
Transmembranei231 – 25121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 595595Bifunctional lycopene cyclase/phytoene synthase
PRO_0000409245Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliD4D802.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 249249Lycopene beta-cyclase
Add
BLAST
Regioni256 – 595340Phytoene synthase
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the lycopene beta-cyclase family.
In the C-terminal section; belongs to the phytoene/squalene synthase family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK17841.
OrthoDBiEOG7RBZJ2.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
PROSITEiPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4D802-1 [UniParc]FASTAAdd to Basket

« Hide

MGLDYLMVHV KYNIPPALLL TILYKPFFTR LEVYKIVFLC TIAVVWTTPW    50
DSYLIRTRVW SYPADSVIGH TIFRIPLEEA FFFIIQTYNT SLIYILFNKR 100
LILLPYLSGP IKPLTQGLFG TVALRTWRDF GILFFTGISV LGISCIRAGG 150
EYMYLGLILS WISPILLLQW PLMYRFLLGL PPASLWVPIV LPTLYLWIVD 200
TLALRRGTWV IESGTKVDIQ LWDGLELEEA LFFLVTNVMI VLGIAGMDNA 250
IALFEYKAFV STTAVGETPS IPRLLTLFFT RSRRYCDTNV LREMSQAVTL 300
LKQKSQTMYL GSAMFEGQLR LDLVALYSFC RKADDLIDDA PNRATAQYWI 350
KQCEKALELR FKLKGAALDN TAAYQQLTKS IPPQLHAAVH LLPASRLPKG 400
PLSDLLKGFE IDMKFDSERG IFPIATEHDL EVYAYHVAGT IATLLLELVF 450
RHHPVSISDS ERLRVISAGE GMGRALQYTN IARDIVRDAE IGRVYIPSVW 500
LAEQGLTPSM VVNQPRNPKL IPLRRRLLDK AEKCYRDTQE AISELPANVR 550
APVRATVTVY MDIGQVIREN EMKVWNGKLK VSRWRRFKGA WLAMS 595
Length:595
Mass (Da):67,801
Last modified:May 18, 2010 - v1
Checksum:iE0171F8312E69275
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACYE01000166 Genomic DNA. Translation: EFE42031.1.
RefSeqiXP_003022649.1. XM_003022603.1.

Genome annotation databases

GeneIDi9581308.
KEGGitve:TRV_03236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACYE01000166 Genomic DNA. Translation: EFE42031.1 .
RefSeqi XP_003022649.1. XM_003022603.1.

3D structure databases

ProteinModelPortali D4D802.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9581308.
KEGGi tve:TRV_03236.

Phylogenomic databases

KOi K17841.
OrthoDBi EOG7RBZJ2.

Enzyme and pathway databases

UniPathwayi UPA00799 ; UER00773 .
UPA00802 .

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00494. SQS_PSY. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
TIGRFAMsi TIGR03462. CarR_dom_SF. 2 hits.
PROSITEi PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HKI 0517.

Entry informationi

Entry nameiLCPS_TRIVH
AccessioniPrimary (citable) accession number: D4D802
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: May 18, 2010
Last modified: February 19, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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