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Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene

TRV_03236

Organism
Trichophyton verrucosum (strain HKI 0517)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).By similarity

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.
2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathwayi

GO - Molecular functioni

  1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB-EC
  2. intramolecular lyase activity Source: InterPro

GO - Biological processi

  1. carotenoid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Transferase

Keywords - Biological processi

Carotenoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.
UPA00802.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lycopene cyclase/phytoene synthase
Including the following 2 domains:
Lycopene beta-cyclase (EC:5.5.1.19)
Alternative name(s):
Lycopene cyclase
Phytoene synthase (EC:2.5.1.32)
Gene namesi
ORF Names:TRV_03236
OrganismiTrichophyton verrucosum (strain HKI 0517)
Taxonomic identifieri663202 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeTrichophyton
ProteomesiUP000008383 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence AnalysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST
Transmembranei130 – 15021HelicalSequence AnalysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST
Transmembranei231 – 25121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 595595Bifunctional lycopene cyclase/phytoene synthasePRO_0000409245Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliD4D802.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 249249Lycopene beta-cyclaseAdd
BLAST
Regioni256 – 595340Phytoene synthaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the lycopene beta-cyclase family.Curated
In the C-terminal section; belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK17841.
OrthoDBiEOG7RBZJ2.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
PROSITEiPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4D802-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLDYLMVHV KYNIPPALLL TILYKPFFTR LEVYKIVFLC TIAVVWTTPW
60 70 80 90 100
DSYLIRTRVW SYPADSVIGH TIFRIPLEEA FFFIIQTYNT SLIYILFNKR
110 120 130 140 150
LILLPYLSGP IKPLTQGLFG TVALRTWRDF GILFFTGISV LGISCIRAGG
160 170 180 190 200
EYMYLGLILS WISPILLLQW PLMYRFLLGL PPASLWVPIV LPTLYLWIVD
210 220 230 240 250
TLALRRGTWV IESGTKVDIQ LWDGLELEEA LFFLVTNVMI VLGIAGMDNA
260 270 280 290 300
IALFEYKAFV STTAVGETPS IPRLLTLFFT RSRRYCDTNV LREMSQAVTL
310 320 330 340 350
LKQKSQTMYL GSAMFEGQLR LDLVALYSFC RKADDLIDDA PNRATAQYWI
360 370 380 390 400
KQCEKALELR FKLKGAALDN TAAYQQLTKS IPPQLHAAVH LLPASRLPKG
410 420 430 440 450
PLSDLLKGFE IDMKFDSERG IFPIATEHDL EVYAYHVAGT IATLLLELVF
460 470 480 490 500
RHHPVSISDS ERLRVISAGE GMGRALQYTN IARDIVRDAE IGRVYIPSVW
510 520 530 540 550
LAEQGLTPSM VVNQPRNPKL IPLRRRLLDK AEKCYRDTQE AISELPANVR
560 570 580 590
APVRATVTVY MDIGQVIREN EMKVWNGKLK VSRWRRFKGA WLAMS
Length:595
Mass (Da):67,801
Last modified:May 17, 2010 - v1
Checksum:iE0171F8312E69275
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACYE01000166 Genomic DNA. Translation: EFE42031.1.
RefSeqiXP_003022649.1. XM_003022603.1.

Genome annotation databases

GeneIDi9581308.
KEGGitve:TRV_03236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACYE01000166 Genomic DNA. Translation: EFE42031.1.
RefSeqiXP_003022649.1. XM_003022603.1.

3D structure databases

ProteinModelPortaliD4D802.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9581308.
KEGGitve:TRV_03236.

Phylogenomic databases

KOiK17841.
OrthoDBiEOG7RBZJ2.

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.
UPA00802.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR008949. Isoprenoid_synthase_dom.
IPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
PROSITEiPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HKI 0517.

Entry informationi

Entry nameiLCPS_TRIVH
AccessioniPrimary (citable) accession number: D4D802
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2011
Last sequence update: May 17, 2010
Last modified: March 31, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.