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D4D802

- LCPS_TRIVH

UniProt

D4D802 - LCPS_TRIVH

Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene

TRV_03236

Organism
Trichophyton verrucosum (strain HKI 0517)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (18 May 2010)
      Previous versions | rss
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    Functioni

    Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).By similarity

    Catalytic activityi

    Carotenoid psi-end group = carotenoid beta-end group.
    2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

    Pathwayi

    GO - Molecular functioni

    1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB-EC
    2. intramolecular lyase activity Source: InterPro

    GO - Biological processi

    1. carotenoid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Transferase

    Keywords - Biological processi

    Carotenoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00799; UER00773.
    UPA00802.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional lycopene cyclase/phytoene synthase
    Including the following 2 domains:
    Lycopene beta-cyclase (EC:5.5.1.19)
    Alternative name(s):
    Lycopene cyclase
    Phytoene synthase (EC:2.5.1.32)
    Gene namesi
    ORF Names:TRV_03236
    OrganismiTrichophyton verrucosum (strain HKI 0517)
    Taxonomic identifieri663202 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaemitosporic ArthrodermataceaeTrichophyton
    ProteomesiUP000008383: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 595595Bifunctional lycopene cyclase/phytoene synthasePRO_0000409245Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliD4D802.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei130 – 15021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei153 – 17321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei231 – 25121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 249249Lycopene beta-cyclaseAdd
    BLAST
    Regioni256 – 595340Phytoene synthaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the lycopene beta-cyclase family.Curated
    In the C-terminal section; belongs to the phytoene/squalene synthase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK17841.
    OrthoDBiEOG7RBZJ2.

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    InterProiIPR017825. Lycopene_cyclase_dom.
    IPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PfamiPF00494. SQS_PSY. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
    PROSITEiPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D4D802-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLDYLMVHV KYNIPPALLL TILYKPFFTR LEVYKIVFLC TIAVVWTTPW    50
    DSYLIRTRVW SYPADSVIGH TIFRIPLEEA FFFIIQTYNT SLIYILFNKR 100
    LILLPYLSGP IKPLTQGLFG TVALRTWRDF GILFFTGISV LGISCIRAGG 150
    EYMYLGLILS WISPILLLQW PLMYRFLLGL PPASLWVPIV LPTLYLWIVD 200
    TLALRRGTWV IESGTKVDIQ LWDGLELEEA LFFLVTNVMI VLGIAGMDNA 250
    IALFEYKAFV STTAVGETPS IPRLLTLFFT RSRRYCDTNV LREMSQAVTL 300
    LKQKSQTMYL GSAMFEGQLR LDLVALYSFC RKADDLIDDA PNRATAQYWI 350
    KQCEKALELR FKLKGAALDN TAAYQQLTKS IPPQLHAAVH LLPASRLPKG 400
    PLSDLLKGFE IDMKFDSERG IFPIATEHDL EVYAYHVAGT IATLLLELVF 450
    RHHPVSISDS ERLRVISAGE GMGRALQYTN IARDIVRDAE IGRVYIPSVW 500
    LAEQGLTPSM VVNQPRNPKL IPLRRRLLDK AEKCYRDTQE AISELPANVR 550
    APVRATVTVY MDIGQVIREN EMKVWNGKLK VSRWRRFKGA WLAMS 595
    Length:595
    Mass (Da):67,801
    Last modified:May 18, 2010 - v1
    Checksum:iE0171F8312E69275
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACYE01000166 Genomic DNA. Translation: EFE42031.1.
    RefSeqiXP_003022649.1. XM_003022603.1.

    Genome annotation databases

    GeneIDi9581308.
    KEGGitve:TRV_03236.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACYE01000166 Genomic DNA. Translation: EFE42031.1 .
    RefSeqi XP_003022649.1. XM_003022603.1.

    3D structure databases

    ProteinModelPortali D4D802.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9581308.
    KEGGi tve:TRV_03236.

    Phylogenomic databases

    KOi K17841.
    OrthoDBi EOG7RBZJ2.

    Enzyme and pathway databases

    UniPathwayi UPA00799 ; UER00773 .
    UPA00802 .

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    InterProi IPR017825. Lycopene_cyclase_dom.
    IPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    Pfami PF00494. SQS_PSY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    TIGRFAMsi TIGR03462. CarR_dom_SF. 2 hits.
    PROSITEi PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HKI 0517.

    Entry informationi

    Entry nameiLCPS_TRIVH
    AccessioniPrimary (citable) accession number: D4D802
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 31, 2011
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3