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D4D802

- LCPS_TRIVH

UniProt

D4D802 - LCPS_TRIVH

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Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene

TRV_03236

Organism
Trichophyton verrucosum (strain HKI 0517)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).By similarity

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.
2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathwayi

GO - Molecular functioni

  1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB-EC
  2. intramolecular lyase activity Source: InterPro

GO - Biological processi

  1. carotenoid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Transferase

Keywords - Biological processi

Carotenoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.
UPA00802.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lycopene cyclase/phytoene synthase
Including the following 2 domains:
Lycopene beta-cyclase (EC:5.5.1.19)
Alternative name(s):
Lycopene cyclase
Phytoene synthase (EC:2.5.1.32)
Gene namesi
ORF Names:TRV_03236
OrganismiTrichophyton verrucosum (strain HKI 0517)
Taxonomic identifieri663202 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeTrichophyton
ProteomesiUP000008383: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 595595Bifunctional lycopene cyclase/phytoene synthasePRO_0000409245Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliD4D802.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalSequence AnalysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST
Transmembranei130 – 15021HelicalSequence AnalysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST
Transmembranei231 – 25121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 249249Lycopene beta-cyclaseAdd
BLAST
Regioni256 – 595340Phytoene synthaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the lycopene beta-cyclase family.Curated
In the C-terminal section; belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK17841.
OrthoDBiEOG7RBZJ2.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
PROSITEiPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D4D802-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLDYLMVHV KYNIPPALLL TILYKPFFTR LEVYKIVFLC TIAVVWTTPW
60 70 80 90 100
DSYLIRTRVW SYPADSVIGH TIFRIPLEEA FFFIIQTYNT SLIYILFNKR
110 120 130 140 150
LILLPYLSGP IKPLTQGLFG TVALRTWRDF GILFFTGISV LGISCIRAGG
160 170 180 190 200
EYMYLGLILS WISPILLLQW PLMYRFLLGL PPASLWVPIV LPTLYLWIVD
210 220 230 240 250
TLALRRGTWV IESGTKVDIQ LWDGLELEEA LFFLVTNVMI VLGIAGMDNA
260 270 280 290 300
IALFEYKAFV STTAVGETPS IPRLLTLFFT RSRRYCDTNV LREMSQAVTL
310 320 330 340 350
LKQKSQTMYL GSAMFEGQLR LDLVALYSFC RKADDLIDDA PNRATAQYWI
360 370 380 390 400
KQCEKALELR FKLKGAALDN TAAYQQLTKS IPPQLHAAVH LLPASRLPKG
410 420 430 440 450
PLSDLLKGFE IDMKFDSERG IFPIATEHDL EVYAYHVAGT IATLLLELVF
460 470 480 490 500
RHHPVSISDS ERLRVISAGE GMGRALQYTN IARDIVRDAE IGRVYIPSVW
510 520 530 540 550
LAEQGLTPSM VVNQPRNPKL IPLRRRLLDK AEKCYRDTQE AISELPANVR
560 570 580 590
APVRATVTVY MDIGQVIREN EMKVWNGKLK VSRWRRFKGA WLAMS
Length:595
Mass (Da):67,801
Last modified:May 18, 2010 - v1
Checksum:iE0171F8312E69275
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACYE01000166 Genomic DNA. Translation: EFE42031.1.
RefSeqiXP_003022649.1. XM_003022603.1.

Genome annotation databases

GeneIDi9581308.
KEGGitve:TRV_03236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACYE01000166 Genomic DNA. Translation: EFE42031.1 .
RefSeqi XP_003022649.1. XM_003022603.1.

3D structure databases

ProteinModelPortali D4D802.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9581308.
KEGGi tve:TRV_03236.

Phylogenomic databases

KOi K17841.
OrthoDBi EOG7RBZJ2.

Enzyme and pathway databases

UniPathwayi UPA00799 ; UER00773 .
UPA00802 .

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00494. SQS_PSY. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
TIGRFAMsi TIGR03462. CarR_dom_SF. 2 hits.
PROSITEi PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HKI 0517.

Entry informationi

Entry nameiLCPS_TRIVH
AccessioniPrimary (citable) accession number: D4D802
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3