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D4D802 (LCPS_TRIVH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional lycopene cyclase/phytoene synthase

Including the following 2 domains:

  1. Lycopene beta-cyclase
    EC=5.5.1.19
    Alternative name(s):
    Lycopene cyclase
  2. Phytoene synthase
    EC=2.5.1.32
Gene names
ORF Names:TRV_03236
OrganismTrichophyton verrucosum (strain HKI 0517) [Complete proteome]
Taxonomic identifier663202 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaemitosporic ArthrodermataceaeTrichophyton

Protein attributes

Sequence length595 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase) By similarity.

Catalytic activity

Carotenoid psi-end group = carotenoid beta-end group.

2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathway

Carotenoid biosynthesis; beta-carotene biosynthesis.

Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

In the N-terminal section; belongs to the lycopene beta-cyclase family.

In the C-terminal section; belongs to the phytoene/squalene synthase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 595595Bifunctional lycopene cyclase/phytoene synthase
PRO_0000409245

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane35 – 5521Helical; Potential
Transmembrane77 – 9721Helical; Potential
Transmembrane130 – 15021Helical; Potential
Transmembrane153 – 17321Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane231 – 25121Helical; Potential
Region1 – 249249Lycopene beta-cyclase
Region256 – 595340Phytoene synthase

Sequences

Sequence LengthMass (Da)Tools
D4D802 [UniParc].

Last modified May 18, 2010. Version 1.
Checksum: E0171F8312E69275

FASTA59567,801
        10         20         30         40         50         60 
MGLDYLMVHV KYNIPPALLL TILYKPFFTR LEVYKIVFLC TIAVVWTTPW DSYLIRTRVW 

        70         80         90        100        110        120 
SYPADSVIGH TIFRIPLEEA FFFIIQTYNT SLIYILFNKR LILLPYLSGP IKPLTQGLFG 

       130        140        150        160        170        180 
TVALRTWRDF GILFFTGISV LGISCIRAGG EYMYLGLILS WISPILLLQW PLMYRFLLGL 

       190        200        210        220        230        240 
PPASLWVPIV LPTLYLWIVD TLALRRGTWV IESGTKVDIQ LWDGLELEEA LFFLVTNVMI 

       250        260        270        280        290        300 
VLGIAGMDNA IALFEYKAFV STTAVGETPS IPRLLTLFFT RSRRYCDTNV LREMSQAVTL 

       310        320        330        340        350        360 
LKQKSQTMYL GSAMFEGQLR LDLVALYSFC RKADDLIDDA PNRATAQYWI KQCEKALELR 

       370        380        390        400        410        420 
FKLKGAALDN TAAYQQLTKS IPPQLHAAVH LLPASRLPKG PLSDLLKGFE IDMKFDSERG 

       430        440        450        460        470        480 
IFPIATEHDL EVYAYHVAGT IATLLLELVF RHHPVSISDS ERLRVISAGE GMGRALQYTN 

       490        500        510        520        530        540 
IARDIVRDAE IGRVYIPSVW LAEQGLTPSM VVNQPRNPKL IPLRRRLLDK AEKCYRDTQE 

       550        560        570        580        590 
AISELPANVR APVRATVTVY MDIGQVIREN EMKVWNGKLK VSRWRRFKGA WLAMS 

« Hide

References

[1]"Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi."
Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S., Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M., Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O., Schroeckh V. expand/collapse author list , Hertweck C., Hube B., White T.C., Platzer M., Guthke R., Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.
Genome Biol. 12:R7.1-R7.16(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HKI 0517.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
ACYE01000166 Genomic DNA. Translation: EFE42031.1.
RefSeqXP_003022649.1. XM_003022603.1.

3D structure databases

ProteinModelPortalD4D802.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9581308.
KEGGtve:TRV_03236.

Phylogenomic databases

KOK17841.
OrthoDBEOG7RBZJ2.

Enzyme and pathway databases

UniPathwayUPA00799; UER00773.
UPA00802.

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 1 hit.
TIGRFAMsTIGR03462. CarR_dom_SF. 2 hits.
PROSITEPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLCPS_TRIVH
AccessionPrimary (citable) accession number: D4D802
Entry history
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: May 18, 2010
Last modified: February 19, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways