D4D6B8 (AMPP2_TRIVH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase TRV_02643
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

ORF Names:

TRV_02643

Organism

Trichophyton verrucosum (strain HKI 0517) [Complete proteome]

Taxonomic identifier

663202 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › Arthrodermataceae › mitosporic Arthrodermataceae › Trichophyton › Trichophyton verrucosum

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	Probable Xaa-Pro aminopeptidase TRV_02643		PRO_0000411854
Sites
	Metal binding	275	1	Manganese 2 By similarity
	Metal binding	286	1	Manganese 1 By similarity
	Metal binding	286	1	Manganese 2 By similarity
	Metal binding	434	1	Manganese 1 By similarity
	Metal binding	478	1	Manganese 1 By similarity
	Metal binding	478	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	D4D6B8 [UniParc]. Last modified May 18, 2010. Version 1. Checksum: 0FF207101B29CDB6	FASTA	507	56,310
	10 20 30 40 50 60 MASYSVTVSV AGTSINKYPA GSAGFDLAMA DSYDPGKQHA RRVAAYLPKQ QGLIYLPGQQ 70 80 90 100 110 120 TVLSEDSDQD RPFKQRRYFF YVTGVVEPDC HVTYDIAEDK LTLYVPDFDF KRTIWTGPTL 130 140 150 160 170 180 GKDEANQRYD VDRVEYFSAL EGDVLRWSQA NPSLSIYILH PDQRPVTPLT VAYFYESKSL 190 200 210 220 230 240 KHAMDACRVI KDEHEIQLIQ RANRVSGAAH RSILANLHHF KNEAQIAGLF IDVCLSLRSK 250 260 270 280 290 300 GTAYQTIAGS GSNGATLHYT RNNEPLAGRQ MVVLDAGAEW SCYASDVTRS FPIPSSVSGG 310 320 330 340 350 360 RDWPSREAEQ IYAIVQRMQE ECISRVKEGA LFFSIHQHAH AIALEELLKL GILRIPQGST 370 380 390 400 410 420 KADLIKAEVT ALFFPHGLGH HLGLEVHDVS PDSGTIPVEL AIEREKGLMS VTEHRPPCTL 430 440 450 460 470 480 SAPPLASGMV ITVEPGLYFN RLAIDQARAE RDEPNSKGRF VNFDVVERYV DVGGVRIEDD 490 500 VLVTKDGNKN LTDAPKGKEM LDLIYGR

References

[1]

"Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi." Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S., Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M., Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O., Schroeckh V. , Hertweck C., Hube B., White T.C., Platzer M., Guthke R., Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A. Genome Biol. 12:R7.1-R7.16(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HKI 0517.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ACYE01000137 Genomic DNA. Translation: EFE42609.1.
RefSeq	XP_003023227.1. XM_003023181.1.
3D structure databases
ProteinModelPortal	D4D6B8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9583246.
KEGG	tve:TRV_02643.
Phylogenomic databases
KO	K14213.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP2_TRIVH

Accession

Primary (citable) accession number: D4D6B8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	May 18, 2010
Last modified:	March 6, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program