Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone-lysine N-methyltransferase

Gene

TRV_02085

Organism
Trichophyton verrucosum (strain HKI 0517)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationSAAS annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
ORF Names:TRV_02085Imported
OrganismiTrichophyton verrucosum (strain HKI 0517)Imported
Taxonomic identifieri663202 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeTrichophyton
Proteomesi
  • UP000008383 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi663202.XP_003023773.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini139 – 194AWSInterPro annotationAdd BLAST56
Domaini196 – 313SETInterPro annotationAdd BLAST118
Domaini320 – 336Post-SETInterPro annotationAdd BLAST17
Domaini598 – 629WWInterPro annotationAdd BLAST32

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4442. Eukaryota.
COG2940. LUCA.
KOiK11423.
OrthoDBiEOG092C3T9B.

Family and domain databases

InterProiView protein in InterPro
IPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
PfamiView protein in Pfam
PF08711. Med26. 1 hit.
PF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
SMARTiView protein in SMART
SM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SUPFAMiSSF47676. SSF47676. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiView protein in PROSITE
PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

D4D4R9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHHDDVDVK TESVADAVTD MKLEREDSEE GVSLNGKTSS NGEANGTPAT
60 70 80 90 100
PAKSAASSPP DRPSSALKDE ESEEKVGGDI TVKQEPGQPP KLARSATKKV
110 120 130 140 150
VPRKPQMFDH LPDSTAEATA LFQVIDACTY SNKNMGYTDH AMECDCAEEW
160 170 180 190 200
NPKTGINEAC GEDSDCINRA TKMECVDNCG CGDNCQNQRF QKRQYADVTV
210 220 230 240 250
IKTEKKGFGL RANTDLRPND FIYEYIGEVI NEPQFRKRMM QYDDEGIKHF
260 270 280 290 300
YFMSLNKGEF VDATRKGNLG RFCNHSCNPN CYIDKWVVGE KLRMGIFAEK
310 320 330 340 350
HIKAGEELVF NYNVDRYGAD PQPCYCGEAN CLGYIGGKTQ TERATKLSNA
360 370 380 390 400
TIEALGIDDL DSWDTALPKR PKKKKTAEDD EEYVDRFQPK SLDEEGVTKV
410 420 430 440 450
MATLMQCKEK WIAVKLLGRM QRCDDERVIN RIVRMHGYQI LNSQLSAWKE
460 470 480 490 500
DFNVVLQILQ ILDKFPRLTR NKIIDSKIET TVKPLTECGE ERVEKQAASL
510 520 530 540 550
LETWSALEVG YRIPRMKRDP ALTANIPSAK QFERREVMRE REDRPRKSAS
560 570 580 590 600
ESRDKSPKSP SVDPTRVAPR GPAAHGRGGK SHRNSYHQGP RPFRRPFNPL
610 620 630 640 650
PSGWFAAEAN GKTYYYSARG DTTWVRPTAP APQPPPPPKP ESKDKTLQDI
660 670 680 690 700
IDGIMNSKED TPKSKDKEVS ATPATPADVP QKKEHKPKWK SLSEEKQKKI
710 720 730 740 750
YENTLFPHVK YVVDKFKNKL PKDDLKRYAK EVAKKLVNSD FKNNRVTDPT
760 770 780 790 800
KVSEKQIKQV KKFCKEYFEK AVVKHQAYEK KKAEHKRKHS KPSDSISNSK
810 820 830 840 850
EPAIPPPTDK ADESDADDDD VNLSDNDEPV QDDVQCSSPR EDESMTPGGS
860 870 880 890 900
LKRKRDIDET VEEEDNDTKH DGSSLSKRQR SESPPVPPPP PPPMSPDNSM
910 920 930 940 950
EVDDIDGGFK RKMDEEFELE DENTPCSRSP GKYNSHGSSP PPFPPPPPLS
960 970
ADMPDRSIDP YRNEQSNMDD ETP
Length:973
Mass (Da):109,748
Last modified:May 18, 2010 - v1
Checksum:i98A141E431AB8E6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACYE01000110 Genomic DNA. Translation: EFE43155.1.
RefSeqiXP_003023773.1. XM_003023727.1.

Genome annotation databases

EnsemblFungiiEFE43155; EFE43155; TRV_02085.
GeneIDi9582347.
KEGGitve:TRV_02085.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiD4D4R9_TRIVH
AccessioniPrimary (citable) accession number: D4D4R9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 18, 2010
Last sequence update: May 18, 2010
Last modified: June 7, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported