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D4CZ59

- DPP4_TRIVH

UniProt

D4CZ59 - DPP4_TRIVH

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Protein
Probable dipeptidyl peptidase 4
Gene
DPP4, TRV_00096
Organism
Trichophyton verrucosum (strain HKI 0517)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Contributes to pathogenicity By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei616 – 6161Charge relay system By similarity
Active sitei668 – 6681Charge relay system By similarity
Active sitei703 – 7031Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl peptidase 4 (EC:3.4.14.5)
Alternative name(s):
Dipeptidyl peptidase IV
Short name:
DPP IV
Short name:
DppIV
Gene namesi
Name:DPP4
ORF Names:TRV_00096
OrganismiTrichophyton verrucosum (strain HKI 0517)
Taxonomic identifieri663202 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaemitosporic ArthrodermataceaeTrichophyton
ProteomesiUP000008383: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 753735Probable dipeptidyl peptidase 4
PRO_0000397815Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi84 – 841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi114 – 1141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi222 – 2221N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliD4CZ59.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal

Phylogenomic databases

KOiK01278.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D4CZ59-1 [UniParc]FASTAAdd to Basket

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MKTSQFLSLL LLAGIAQAIV PPREPRPPTG GGNKLLTYKE CVPRATISPR    50
STSLAWINSD EDGQYISQSD DGALILQNIV TNTNKTLVAA DKVPKGYYDY 100
WFKPDLSAVL WATNYTKQYR HSYFANYFIL DIEKGSLTPL AQDQAGDIQY 150
AQWSPMDNSI AYVRGNDLYI WNNGKTKRIT ENGGPDIFNG VPDWVYEEEI 200
FGDRFALWFS PDGEYLAYLR FNETGVPTYT IPYYKNKQKI APAYPRELEI 250
RYPKVSAKNP TVQFHLLNIA SSQETTIPVT AFPENDLVIG EVAWLSSGHD 300
SVAYRAFNRV QDREKIVSVK VESKESKVIR ERDGTDGWID NLLSMSYIGD 350
VNGKEYYVDI SDASGWAHIY LYPVDGGKEI ALTTGEWEVV AILKVDTMKK 400
LIYFTSTKYH STTRHVYSVS YDTKVMTPLV NDKEAAYYTA SFSAKGGYYI 450
LSYQGPNVPY QELYSTKDSK KPLKTITSND ALLEKLKEYK LPKVSFFEIK 500
LPSGETLNVK QRLPPNFNPH KKYPVLFTPY GGPGAQEVSQ AWNSLDFKSY 550
ITSDPELEYV TWTVDNRGTG YKGRKFRSAV AKRLGFLEPQ DQVFAAKELL 600
KNRWADKDHI GIWGWSYGGF LTAKTLETDS GVFTFGISTA PVSDFRLYDS 650
MYTERYMKTV ELNADGCDDN VHFQNAAVLS NTLMNGGVTA DKLTTQWFTD 700
SDHGIRYDMD STYQYKQLAK MVYDQKQRRP ERPPMHQWSK RVLAALFGER 750
AEE 753
Length:753
Mass (Da):85,635
Last modified:May 18, 2010 - v1
Checksum:i02B1752AB9C6F26E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACYE01000004 Genomic DNA. Translation: EFE45114.1.
RefSeqiXP_003025725.1. XM_003025679.1.

Genome annotation databases

GeneIDi9581968.
KEGGitve:TRV_00096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACYE01000004 Genomic DNA. Translation: EFE45114.1 .
RefSeqi XP_003025725.1. XM_003025679.1.

3D structure databases

ProteinModelPortali D4CZ59.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9581968.
KEGGi tve:TRV_00096.

Phylogenomic databases

KOi K01278.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HKI 0517.

Entry informationi

Entry nameiDPP4_TRIVH
AccessioniPrimary (citable) accession number: D4CZ59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: May 18, 2010
Last modified: June 11, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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