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D4CZ59

- DPP4_TRIVH

UniProt

D4CZ59 - DPP4_TRIVH

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Protein

Probable dipeptidyl peptidase 4

Gene

DPP4

Organism
Trichophyton verrucosum (strain HKI 0517)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Contributes to pathogenicity (By similarity).By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei616 – 6161Charge relay systemPROSITE-ProRule annotation
Active sitei668 – 6681Charge relay systemPROSITE-ProRule annotation
Active sitei703 – 7031Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl peptidase 4 (EC:3.4.14.5)
Alternative name(s):
Dipeptidyl peptidase IV
Short name:
DPP IV
Short name:
DppIV
Gene namesi
Name:DPP4
ORF Names:TRV_00096
OrganismiTrichophyton verrucosum (strain HKI 0517)
Taxonomic identifieri663202 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeTrichophyton
ProteomesiUP000008383: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 753735Probable dipeptidyl peptidase 4PRO_0000397815Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliD4CZ59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK01278.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D4CZ59-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTSQFLSLL LLAGIAQAIV PPREPRPPTG GGNKLLTYKE CVPRATISPR
60 70 80 90 100
STSLAWINSD EDGQYISQSD DGALILQNIV TNTNKTLVAA DKVPKGYYDY
110 120 130 140 150
WFKPDLSAVL WATNYTKQYR HSYFANYFIL DIEKGSLTPL AQDQAGDIQY
160 170 180 190 200
AQWSPMDNSI AYVRGNDLYI WNNGKTKRIT ENGGPDIFNG VPDWVYEEEI
210 220 230 240 250
FGDRFALWFS PDGEYLAYLR FNETGVPTYT IPYYKNKQKI APAYPRELEI
260 270 280 290 300
RYPKVSAKNP TVQFHLLNIA SSQETTIPVT AFPENDLVIG EVAWLSSGHD
310 320 330 340 350
SVAYRAFNRV QDREKIVSVK VESKESKVIR ERDGTDGWID NLLSMSYIGD
360 370 380 390 400
VNGKEYYVDI SDASGWAHIY LYPVDGGKEI ALTTGEWEVV AILKVDTMKK
410 420 430 440 450
LIYFTSTKYH STTRHVYSVS YDTKVMTPLV NDKEAAYYTA SFSAKGGYYI
460 470 480 490 500
LSYQGPNVPY QELYSTKDSK KPLKTITSND ALLEKLKEYK LPKVSFFEIK
510 520 530 540 550
LPSGETLNVK QRLPPNFNPH KKYPVLFTPY GGPGAQEVSQ AWNSLDFKSY
560 570 580 590 600
ITSDPELEYV TWTVDNRGTG YKGRKFRSAV AKRLGFLEPQ DQVFAAKELL
610 620 630 640 650
KNRWADKDHI GIWGWSYGGF LTAKTLETDS GVFTFGISTA PVSDFRLYDS
660 670 680 690 700
MYTERYMKTV ELNADGCDDN VHFQNAAVLS NTLMNGGVTA DKLTTQWFTD
710 720 730 740 750
SDHGIRYDMD STYQYKQLAK MVYDQKQRRP ERPPMHQWSK RVLAALFGER

AEE
Length:753
Mass (Da):85,635
Last modified:May 18, 2010 - v1
Checksum:i02B1752AB9C6F26E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACYE01000004 Genomic DNA. Translation: EFE45114.1.
RefSeqiXP_003025725.1. XM_003025679.1.

Genome annotation databases

GeneIDi9581968.
KEGGitve:TRV_00096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACYE01000004 Genomic DNA. Translation: EFE45114.1 .
RefSeqi XP_003025725.1. XM_003025679.1.

3D structure databases

ProteinModelPortali D4CZ59.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9581968.
KEGGi tve:TRV_00096.

Phylogenomic databases

KOi K01278.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HKI 0517.

Entry informationi

Entry nameiDPP4_TRIVH
AccessioniPrimary (citable) accession number: D4CZ59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3