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D4B5L8

- KEX1_ARTBC

UniProt

D4B5L8 - KEX1_ARTBC

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei154 – 1541PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:ARB_03758
OrganismiArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Taxonomic identifieri663331 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
ProteomesiUP000008866: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 596579Pheromone-processing carboxypeptidase KEX1PRO_0000411899Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi367 – 3671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi404 – 4041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi412 – 4121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi464 – 4641N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 486469LumenalSequence AnalysisAdd
BLAST
Topological domaini508 – 59689CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei487 – 50721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D4B5L8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGLATTVTL ESSGCSSKMC FRLLCSVSSR PARGTFVEDA CWVYIISHTF
60 70 80 90 100
FPFNMTWRVV NIFISLSMDG ALMEIGPYRL QDDHTLIYNN GSWDEFANLL
110 120 130 140 150
FVDQPVGTGF SYVSTDSYVR ELGPMADQFV TFLERWFNVF PEYERDDIYI
160 170 180 190 200
AGESYAGQYI PYIADAIVRR NEKLSANGTS WNVQGLLIGN GWISPLEQYR
210 220 230 240 250
SYLPFSYKEG VLDKNSDGAK AAESQLSKCM SKLKEVGKFG VHVDECERVL
260 270 280 290 300
ELILDTTKVD GKCINMYDVR LEDTPDACGM NWPPDISLVT SYLRRPDVVK
310 320 330 340 350
ALNINEDKTT GWRECSPGVG RNLQATESVP SVQLLPGLLE RGMPIVLFSG
360 370 380 390 400
DKDLICNHIG TEDLIHNMTW LNATGFELSP DVWAPRHNWE FEGSAAGIYQ
410 420 430 440 450
QARNLTYVKF YNASHMVPFD FPRRSRDMLD RFLGIDITSI GGDPADSRID
460 470 480 490 500
GLKGAPTSVG AHPNSTTAEE KEKEKIKIAA WEAYYKSGEV ALVVVAIAAS
510 520 530 540 550
LWGFFIWRSK RREKGLEYKG IYPNLESFSS ASLATFRGKR RGRMDVESAP
560 570 580 590
RPDEAELETL YNAAEGSDPQ DGEENFSDGK GDNEKAQSHA GMGKSR
Length:596
Mass (Da):66,677
Last modified:May 18, 2010 - v1
Checksum:i3BD06AC1853CA859
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABSU01000043 Genomic DNA. Translation: EFE29379.1.
RefSeqiXP_003010019.1. XM_003009973.1.

Genome annotation databases

GeneIDi9525614.
KEGGiabe:ARB_03758.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ABSU01000043 Genomic DNA. Translation: EFE29379.1 .
RefSeqi XP_003010019.1. XM_003009973.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9525614.
KEGGi abe:ARB_03758.

Phylogenomic databases

KOi K01288.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4681 / CBS 112371.

Entry informationi

Entry nameiKEX1_ARTBC
AccessioniPrimary (citable) accession number: D4B5L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3