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D4B5L8 (KEX1_ARTBC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
ORF Names:ARB_03758
OrganismArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes) [Complete proteome]
Taxonomic identifier663331 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma

Protein attributes

Sequence length596 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 596579Pheromone-processing carboxypeptidase KEX1
PRO_0000411899

Regions

Topological domain18 – 486469Lumenal Potential
Transmembrane487 – 50721Helical; Potential
Topological domain508 – 59689Cytoplasmic Potential

Sites

Active site1541 By similarity

Amino acid modifications

Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation901N-linked (GlcNAc...) Potential
Glycosylation1771N-linked (GlcNAc...) Potential
Glycosylation3671N-linked (GlcNAc...) Potential
Glycosylation3721N-linked (GlcNAc...) Potential
Glycosylation4041N-linked (GlcNAc...) Potential
Glycosylation4121N-linked (GlcNAc...) Potential
Glycosylation4641N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
D4B5L8 [UniParc].

Last modified May 18, 2010. Version 1.
Checksum: 3BD06AC1853CA859

FASTA59666,677
        10         20         30         40         50         60 
MLGLATTVTL ESSGCSSKMC FRLLCSVSSR PARGTFVEDA CWVYIISHTF FPFNMTWRVV 

        70         80         90        100        110        120 
NIFISLSMDG ALMEIGPYRL QDDHTLIYNN GSWDEFANLL FVDQPVGTGF SYVSTDSYVR 

       130        140        150        160        170        180 
ELGPMADQFV TFLERWFNVF PEYERDDIYI AGESYAGQYI PYIADAIVRR NEKLSANGTS 

       190        200        210        220        230        240 
WNVQGLLIGN GWISPLEQYR SYLPFSYKEG VLDKNSDGAK AAESQLSKCM SKLKEVGKFG 

       250        260        270        280        290        300 
VHVDECERVL ELILDTTKVD GKCINMYDVR LEDTPDACGM NWPPDISLVT SYLRRPDVVK 

       310        320        330        340        350        360 
ALNINEDKTT GWRECSPGVG RNLQATESVP SVQLLPGLLE RGMPIVLFSG DKDLICNHIG 

       370        380        390        400        410        420 
TEDLIHNMTW LNATGFELSP DVWAPRHNWE FEGSAAGIYQ QARNLTYVKF YNASHMVPFD 

       430        440        450        460        470        480 
FPRRSRDMLD RFLGIDITSI GGDPADSRID GLKGAPTSVG AHPNSTTAEE KEKEKIKIAA 

       490        500        510        520        530        540 
WEAYYKSGEV ALVVVAIAAS LWGFFIWRSK RREKGLEYKG IYPNLESFSS ASLATFRGKR 

       550        560        570        580        590 
RGRMDVESAP RPDEAELETL YNAAEGSDPQ DGEENFSDGK GDNEKAQSHA GMGKSR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
ABSU01000043 Genomic DNA. Translation: EFE29379.1.
RefSeqXP_003010019.1. XM_003009973.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9525614.
KEGGabe:ARB_03758.

Phylogenomic databases

KOK01288.
OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_ARTBC
AccessionPrimary (citable) accession number: D4B5L8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 18, 2010
Last modified: June 11, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries