Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Exo-alpha-sialidase ARB_03431

Gene

ARB_03431

Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sialidase is able to release sialic acid from a wide variety of natural substrates.By similarity

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621SubstrateBy similarity
Binding sitei81 – 811SubstrateBy similarity
Binding sitei87 – 871SubstrateBy similarity
Binding sitei150 – 1501SubstrateBy similarity
Binding sitei267 – 2671SubstrateBy similarity
Binding sitei324 – 3241SubstrateBy similarity
Binding sitei339 – 3391Substrate; via carbonyl oxygenBy similarity
Binding sitei360 – 3601SubstrateBy similarity
Binding sitei378 – 3781SubstrateBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Exo-alpha-sialidase ARB_03431Curated (EC:3.2.1.18By similarity)
Alternative name(s):
Alpha-neuraminidase ARB_03431Curated
N-acylneuraminate glycohydrolase ARB_03431Curated
Gene namesi
ORF Names:ARB_03431
OrganismiArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Taxonomic identifieri663331 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
ProteomesiUP000008866 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 408386Exo-alpha-sialidase ARB_03431PRO_5003054503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi237 – 2371N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi398 – 3981N-linked (GlcNAc...)PROSITE-ProRule annotation

Keywords - PTMi

Glycoprotein

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni324 – 3252Substrate bindingBy similarity
Regioni333 – 3342Substrate bindingBy similarity
Regioni378 – 3803Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the glycosyl hydrolase 33 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHFZ. Eukaryota.
ENOG4112A1R. LUCA.
KOiK01186.
OrthoDBiEOG7T4MW1.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF13088. BNR_2. 1 hit.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D4B4P1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIKQWLLSL VVVAISATAT QARVDDPAGK AAQYHKEYAL FRSANMPSPD
60 70 80 90 100
KLASGVGFHS FRIPAVVRTN TGRILAFAEG RRHNNRDYGD INLVYKRTKS
110 120 130 140 150
PTNNGENPTD WESLREVVGT GPHTWGNPTP VVDGNTIYLF LSMNDGAYSQ
160 170 180 190 200
NGGNTLPDGT KTKTIDSTWV GRRHLYLTTS TDDGDTWTKP VDMTKTLTPD
210 220 230 240 250
GQAWDAVGPG NGIKLSTGEL VIPAQGRNII GHGPSGNRTW SMQVLKGAGS
260 270 280 290 300
EGTICQTPDG KLMRNDRPGP MGHRSVARGT LAGFGPFATD NGLPDPACQG
310 320 330 340 350
SILSYNSDEP ARTIFMNSAS TDRRTAMRVR ISYDKDAAKF NFGRELKDAP
360 370 380 390 400
LGNVGNEGGY SSMTKTSDYK IGALVESDWY EDKGGEKSHR CIIWRRFNLS

WIINGPNN
Length:408
Mass (Da):44,403
Last modified:May 18, 2010 - v1
Checksum:i92E2434E1EAB1BC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABSU01000034 Genomic DNA. Translation: EFE30089.1.
RefSeqiXP_003010729.1. XM_003010683.1.

Genome annotation databases

EnsemblFungiiEFE30089; EFE30089; ARB_03431.
GeneIDi9524842.
KEGGiabe:ARB_03431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABSU01000034 Genomic DNA. Translation: EFE30089.1.
RefSeqiXP_003010729.1. XM_003010683.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFE30089; EFE30089; ARB_03431.
GeneIDi9524842.
KEGGiabe:ARB_03431.

Phylogenomic databases

eggNOGiENOG410IHFZ. Eukaryota.
ENOG4112A1R. LUCA.
KOiK01186.
OrthoDBiEOG7T4MW1.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF13088. BNR_2. 1 hit.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4681 / CBS 112371.
  2. "Identification of novel secreted proteases during extracellular proteolysis by dermatophytes at acidic pH."
    Sriranganadane D., Waridel P., Salamin K., Feuermann M., Mignon B., Staib P., Neuhaus J.M., Quadroni M., Monod M.
    Proteomics 11:4422-4433(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSIA_ARTBC
AccessioniPrimary (citable) accession number: D4B4P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2016
Last sequence update: May 18, 2010
Last modified: January 20, 2016
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.