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Protein

Exo-alpha-sialidase ARB_03431

Gene

ARB_03431

Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sialidase is able to release sialic acid from a wide variety of natural substrates.By similarity

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62SubstrateBy similarity1
Binding sitei81SubstrateBy similarity1
Binding sitei87SubstrateBy similarity1
Binding sitei150SubstrateBy similarity1
Binding sitei267SubstrateBy similarity1
Binding sitei324SubstrateBy similarity1
Binding sitei339Substrate; via carbonyl oxygenBy similarity1
Binding sitei360SubstrateBy similarity1
Binding sitei378SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Exo-alpha-sialidase ARB_03431Curated (EC:3.2.1.18By similarity)
Alternative name(s):
Alpha-neuraminidase ARB_03431Curated
N-acylneuraminate glycohydrolase ARB_03431Curated
Gene namesi
ORF Names:ARB_03431
OrganismiArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Taxonomic identifieri663331 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
Proteomesi
  • UP000008866 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500305450323 – 408Exo-alpha-sialidase ARB_03431Add BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi237N-linked (GlcNAc...)PROSITE-ProRule annotation1
Glycosylationi398N-linked (GlcNAc...)PROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni324 – 325Substrate bindingBy similarity2
Regioni333 – 334Substrate bindingBy similarity2
Regioni378 – 380Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the glycosyl hydrolase 33 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHFZ. Eukaryota.
ENOG4112A1R. LUCA.
KOiK01186.
OrthoDBiEOG092C2A0R.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF13088. BNR_2. 1 hit.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D4B4P1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIKQWLLSL VVVAISATAT QARVDDPAGK AAQYHKEYAL FRSANMPSPD
60 70 80 90 100
KLASGVGFHS FRIPAVVRTN TGRILAFAEG RRHNNRDYGD INLVYKRTKS
110 120 130 140 150
PTNNGENPTD WESLREVVGT GPHTWGNPTP VVDGNTIYLF LSMNDGAYSQ
160 170 180 190 200
NGGNTLPDGT KTKTIDSTWV GRRHLYLTTS TDDGDTWTKP VDMTKTLTPD
210 220 230 240 250
GQAWDAVGPG NGIKLSTGEL VIPAQGRNII GHGPSGNRTW SMQVLKGAGS
260 270 280 290 300
EGTICQTPDG KLMRNDRPGP MGHRSVARGT LAGFGPFATD NGLPDPACQG
310 320 330 340 350
SILSYNSDEP ARTIFMNSAS TDRRTAMRVR ISYDKDAAKF NFGRELKDAP
360 370 380 390 400
LGNVGNEGGY SSMTKTSDYK IGALVESDWY EDKGGEKSHR CIIWRRFNLS

WIINGPNN
Length:408
Mass (Da):44,403
Last modified:May 18, 2010 - v1
Checksum:i92E2434E1EAB1BC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABSU01000034 Genomic DNA. Translation: EFE30089.1.
RefSeqiXP_003010729.1. XM_003010683.1.

Genome annotation databases

EnsemblFungiiEFE30089; EFE30089; ARB_03431.
GeneIDi9524842.
KEGGiabe:ARB_03431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABSU01000034 Genomic DNA. Translation: EFE30089.1.
RefSeqiXP_003010729.1. XM_003010683.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFE30089; EFE30089; ARB_03431.
GeneIDi9524842.
KEGGiabe:ARB_03431.

Phylogenomic databases

eggNOGiENOG410IHFZ. Eukaryota.
ENOG4112A1R. LUCA.
KOiK01186.
OrthoDBiEOG092C2A0R.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF13088. BNR_2. 1 hit.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSIA_ARTBC
AccessioniPrimary (citable) accession number: D4B4P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2016
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.