ID   D4B2Y3_ARTBC            Unreviewed;       474 AA.
AC   D4B2Y3;
DT   18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT   18-MAY-2010, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   SubName: Full=Histone-lysine N-methyltransferase Clr4 {ECO:0000313|EMBL:EFE30279.1};
GN   ORFNames=ARB_02816 {ECO:0000313|EMBL:EFE30279.1};
OS   Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS   mentagrophytes).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=663331 {ECO:0000313|EMBL:EFE30279.1, ECO:0000313|Proteomes:UP000008866};
RN   [1] {ECO:0000313|Proteomes:UP000008866}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4681 / CBS 112371 {ECO:0000313|Proteomes:UP000008866};
RX   PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA   Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA   Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA   Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA   Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA   Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT   "Comparative and functional genomics provide insights into the
RT   pathogenicity of dermatophytic fungi.";
RL   Genome Biol. 12:R7.1-R7.16(2011).
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFE30279.1}.
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DR   EMBL; ABSU01000031; EFE30279.1; -; Genomic_DNA.
DR   RefSeq; XP_003010919.1; XM_003010873.1.
DR   AlphaFoldDB; D4B2Y3; -.
DR   STRING; 663331.D4B2Y3; -.
DR   GeneID; 9525035; -.
DR   KEGG; abe:ARB_02816; -.
DR   eggNOG; KOG1082; Eukaryota.
DR   HOGENOM; CLU_020840_11_1_1; -.
DR   OMA; TKCLCGE; -.
DR   OrthoDB; 5481936at2759; -.
DR   Proteomes; UP000008866; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR007728; Pre-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   PANTHER; PTHR46223:SF3; HISTONE H3 (LYS9) METHYLTRANSFERASE-RELATED; 1.
DR   PANTHER; PTHR46223; HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H; 1.
DR   Pfam; PF05033; Pre-SET; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00468; PreSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:EFE30279.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008866};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EFE30279.1}.
FT   DOMAIN          290..420
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          431..447
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
FT   REGION          27..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          448..474
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..71
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..100
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   474 AA;  53588 MW;  ED1F1608F24E4C62 CRC64;
     MVTVLDSDSD EETFIQPEVI SSRLLKAFIS PEDDRQRQSP SKPPSKPRRA VVDKGSTSSS
     SRPQSKASNV SVVIPVPPRR PSPSPVTTSR KRSLSSDGDI NKALSRKLTA TKIPDHHGLS
     DFYAVESGEV KRPYLKLKTF DPKKTEIPRS SKRYIPPKRR SDKESACSRL EELYNKKLQR
     IKGPPIRFKA GKIAKEIDFN FDFIDSYKIH SGVNQIDPEF LWGCDCTKCD AECDCLSKDL
     VHYEKGRRVR AVLKSEILNK RTALIRECSS RCKCSGVNCW NHVVFRGRQV ELEVFQTKNR
     GFGVRSPHSI ERGQFIDTYV GEVIEPSTSD AREEAIDVEK YSSYLFSLDY FPGEEYEKEK
     DIYVVDGRKF GSITRFMNHS CNPNCKMFPA TQTDDHGVYQ LAFFAVRDIP AGTELTFDYH
     PGWEGGDVDP DATKCLCGEK NCRGQLWPAK RKTTRPGEDS SSSGESSEES EDDE
//