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Protein

Putative dipeptidase ARB_02715

Gene

ARB_02715

Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes a wide range of dipeptides.By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zn2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi45 – 451Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi47 – 471Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi157 – 1571Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi157 – 1571Zinc 2; catalyticPROSITE-ProRule annotation
Binding sitei184 – 1841SubstratePROSITE-ProRule annotation
Metal bindingi228 – 2281Zinc 2; catalyticPROSITE-ProRule annotation
Metal bindingi249 – 2491Zinc 2; catalyticPROSITE-ProRule annotation
Binding sitei260 – 2601SubstratePROSITE-ProRule annotation
Binding sitei320 – 3201SubstratePROSITE-ProRule annotation

GO - Molecular functioni

  1. dipeptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. metallopeptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM19.A01.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative dipeptidase ARB_02715 (EC:3.4.13.19)
Gene namesi
ORF Names:ARB_02715
OrganismiArthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Taxonomic identifieri663331 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeArthroderma
ProteomesiUP000008866: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 414394Putative dipeptidase ARB_02715PRO_0000411210Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi96 ↔ 186PROSITE-ProRule annotation
Glycosylationi392 – 3921N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliD4B2N2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

KOiK01273.
OrthoDBiEOG7XM371.

Family and domain databases

InterProiIPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D4B2N2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALFVSLLA LTSLVPVQGA ATVPQTDYAK RAERVLRSAP LIDGHNDLPY
60 70 80 90 100
AIRRSTNDQI YDGKLPFETS LKGHTDLPRM RKGRMGGQFW SVFIACPSDP
110 120 130 140 150
NAPINTPKFA TRDTLEQIDV ARRLVDKYSK DLMYCDNPGC AKRAFREGKI
160 170 180 190 200
GSFIGIEGGH QVGSSIAALR QAFYAGARYM TLTHNCDNAW ATAASTVRAG
210 220 230 240 250
KPDLGMTDFG PALIKEMNRL GMLVDLSHVS HQTMRDVLKI TKAPVIFSHS
260 270 280 290 300
SAYEVSKHLR NVPDDVLKTV AKNNGVVMVT FVSSFVKVDD PDSADVNTVV
310 320 330 340 350
KHIFHIAEVA GWDHVGLGGD YDGTTELPKG LEDVSKYPYL IEKVLEAGAT
360 370 380 390 400
EEQARKLVGE NVLRVWTEVE QIAKKIQRSG VLPVEEVWKG RNGTALSERS
410
TFIEGPAPLE YGCD
Length:414
Mass (Da):45,419
Last modified:May 18, 2010 - v1
Checksum:i497B6C978E2F9E81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABSU01000030 Genomic DNA. Translation: EFE30343.1.
RefSeqiXP_003010983.1. XM_003010937.1.

Genome annotation databases

GeneIDi9525100.
KEGGiabe:ARB_02715.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABSU01000030 Genomic DNA. Translation: EFE30343.1.
RefSeqiXP_003010983.1. XM_003010937.1.

3D structure databases

ProteinModelPortaliD4B2N2.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM19.A01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9525100.
KEGGiabe:ARB_02715.

Phylogenomic databases

KOiK01273.
OrthoDBiEOG7XM371.

Family and domain databases

InterProiIPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4681 / CBS 112371.

Entry informationi

Entry nameiDPEP1_ARTBC
AccessioniPrimary (citable) accession number: D4B2N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 18, 2010
Last modified: January 7, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.