ID   D4B0M3_ARTBC            Unreviewed;       670 AA.
AC   D4B0M3;
DT   18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT   18-MAY-2010, sequence version 1.
DT   13-SEP-2023, entry version 59.
DE   SubName: Full=Glucokinase, putative {ECO:0000313|EMBL:EFE31130.1};
GN   ORFNames=ARB_01999 {ECO:0000313|EMBL:EFE31130.1};
OS   Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS   mentagrophytes).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=663331 {ECO:0000313|EMBL:EFE31130.1, ECO:0000313|Proteomes:UP000008866};
RN   [1] {ECO:0000313|Proteomes:UP000008866}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4681 / CBS 112371 {ECO:0000313|Proteomes:UP000008866};
RX   PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA   Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA   Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA   Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA   Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA   Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT   "Comparative and functional genomics provide insights into the
RT   pathogenicity of dermatophytic fungi.";
RL   Genome Biol. 12:R7.1-R7.16(2011).
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 1/4.
CC       {ECO:0000256|ARBA:ARBA00004888}.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|ARBA:ARBA00009225}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFE31130.1}.
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DR   EMBL; ABSU01000024; EFE31130.1; -; Genomic_DNA.
DR   RefSeq; XP_003011770.1; XM_003011724.1.
DR   AlphaFoldDB; D4B0M3; -.
DR   STRING; 663331.D4B0M3; -.
DR   GeneID; 9523543; -.
DR   KEGG; abe:ARB_01999; -.
DR   eggNOG; KOG1369; Eukaryota.
DR   HOGENOM; CLU_014393_5_0_1; -.
DR   OMA; YPNFEGY; -.
DR   OrthoDB; 5481886at2759; -.
DR   UniPathway; UPA00109; UER00180.
DR   Proteomes; UP000008866; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.40.367.20; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443:SF30; GLUCOKINASE-1-RELATED; 1.
DR   PANTHER; PTHR19443; HEXOKINASE; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PRINTS; PR00475; HEXOKINASE.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   PROSITE; PS00378; HEXOKINASE_1; 1.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EFE31130.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008866};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        52..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          146..358
FT                   /note="Hexokinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00349"
FT   DOMAIN          368..620
FT                   /note="Hexokinase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03727"
SQ   SEQUENCE   670 AA;  73307 MW;  70D78B46FD49BD24 CRC64;
     MRHAGRQSMF PSALQKALVS ISRPPKENTG RAASLPTTTD KKLSIFNSLS PSLYYFVLPI
     ILIIIHLLLT STVPALPADG PSIPRVSFLK SSPLLFFLAS RHNTEQTPPE YLRQWCESPY
     LQGLLDPEQI FSICPSKMAS AVLEEAKRIS AGFEYSTEEL NKGVEEFLRE MEVGLSREDS
     GLSQIPSYIT SVPDGTEKGV YLAVDLGGTN LRVCSVHLHG NSTHEMIQSK SAIPRELMVA
     EHGVELFNFL AKQIEAFLRE HHAEQFSSHV EKRQTGEVKE PYAEEQVFDL GFTFSFPVIQ
     HGINKGELYR WTKGFDIPEV VGKDICQLLQ AAIDELKLPV RVSALINDTV GTLMARSYCS
     PGNSRTLIGA IFGTGTNGAY VEKMPRVTKM ERCSSSAYNK SASEMVINAE WGSFDNSLKV
     LPNTEFDIQL DNATFNPGIQ MFEKRISGMF LGEILRLAIL SMVENPSVSL FGSPATIDSN
     SVLYKAWAID ASILSIIEGD DSEGLQATKE QLRKDLDIMD VSTSDCQAVK LLAHSIGKRA
     ARLGAIALGA IVISSGRLAT DEVVDIGVDG SLIEHYPGFE GYIREAFREI PAIGPAGEKK
     IRIGIAKDGS GVGAALGALV AKRTSQTLQV MPPIRACPLS MTYIMQNITI KLTIKLTIKL
     TIKLTITICS
//